2014
DOI: 10.1186/2052-8426-2-31
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Abstract: Neural stem cells (NSCs) offer a unique and powerful tool for basic research and regenerative medicine. However, the challenges that scientists face in the comprehension of the biology and physiological function of these cells are still many. Deciphering NSCs fundamental biological aspects represents indeed a crucial step to control NSCs fate and functional integration following transplantation, and is essential for a safe and appropriate use of NSCs in injury/disease conditions. In this review, we focus on th… Show more

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Cited by 66 publications
(53 citation statements)
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“…The grafting of NSCs with other cell types has provided a proof of concept for cell therapy approaches to neurodegenerative diseases in a number of preclinical studies, including Parkinson' s and Huntington's treatment . Upon transplantation, NSCs not only replace lost cells, but also may release molecules that stimulate the regenerative potential and increase the survival of the remaining local cells (where present), thus slowing disease progression in several animals models . However, NSC‐based therapies still face several hurdles, such as low survival rate of the transplanted cells and a disappointing functional outcome upon grafting into the damaged brain.…”
Section: Introductionmentioning
confidence: 99%
“…The grafting of NSCs with other cell types has provided a proof of concept for cell therapy approaches to neurodegenerative diseases in a number of preclinical studies, including Parkinson' s and Huntington's treatment . Upon transplantation, NSCs not only replace lost cells, but also may release molecules that stimulate the regenerative potential and increase the survival of the remaining local cells (where present), thus slowing disease progression in several animals models . However, NSC‐based therapies still face several hurdles, such as low survival rate of the transplanted cells and a disappointing functional outcome upon grafting into the damaged brain.…”
Section: Introductionmentioning
confidence: 99%
“…Current pharmacological-based treatments of these diseases are inadequate as they only treat symptoms and not the underlying disease etiology—the damage, degeneration, and death of the neurons and supporting cell types of the CNS. Stem-cell based technologies have emerged as a promising approach for the study and treatment of these diseases (13). Specifically, human pluripotent stem cell (hPSC)-derived neural progenitor cells (hNPCs), a multipotent cell population that is capable of extensive in vitro expansion and subsequent differentiation into the various cell types that comprise the CNS, could provide an unlimited source of cells for such cell-based therapies (2, 46).…”
Section: Introductionmentioning
confidence: 99%
“…Specifically, human pluripotent stem cell (hPSC)-derived neural progenitor cells (hNPCs), a multipotent cell population that is capable of extensive in vitro expansion and subsequent differentiation into the various cell types that comprise the CNS, could provide an unlimited source of cells for such cell-based therapies (2, 46). In fact, recent research supports the use of these cells as the basis for regenerative medicine therapies to reverse or arrest neurodegeneration or replace dead or diseased neural cells (2, 3, 68). In addition, generating neural cells from human disease specific hPSCs is of particular interest because animal models of neurodegenerative diseases do not display important pathological hallmarks and do not adequately model the complex genetics associated with human neurodegenerative diseases (912).…”
Section: Introductionmentioning
confidence: 99%
“…Nonetheless, neural stem cells have been identified in the adult central nervous system, albeit mainly limited to restricted regions of the hippocampal dentate gyrus 17 and the subventricular zone of the lateral ventricular wall 18 . Harnessing the therapeutic potential of the neural stem cells could be possible either through stimulating their regenerative capacity in vivo, or purifying them and expanding in vitro prior to the therapeutic applications 19 . However, given the difficulties in isolating neural stem cells from in vivo sources, a promising alternative supply of neural stem cells are human pluripotent stem cells, which appear to have the ability to generate large numbers of neural stem cells that can be patterned to various sub-types useful for regenerative medicine 20 .…”
Section: Multipotent Stem Cellsmentioning
confidence: 99%