Neural Correlates of Healthy Sustained Vowel Phonation Tasks: A Systematic Review and Meta-Analysis of Neuroimaging Studies

Dedry, Marie; Maryn, Youri; Szmalec, Arnaud; Lith-Bijl, J. van; Dricot, Laurence; Desuter, Gauthier

doi:10.1016/j.jvoice.2022.02.008

Cited by 1 publication

(6 citation statements)

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“…Regions activated for the PHONATION contrast when the MOBILE runs were pooled, compared to forty-three coordinates or clusters of activation highlighted in our literature review of fMRI sustained vowel phonation tasks ( Dedry et al, 2022 ), are illustrated in Figure 3 . When examined, 35/43 ROI were significantly activated or contained an activation peak ( p < 0.05).…”

Section: Resultsmentioning

confidence: 99%

“… Activation map for the “Mobile” runs. The upper part is excerpted from a figure in the Dedry et al (2022) review of literature. The clusters and coordinates of interest were represented on a brain map at two Z coordinates in MNI.…”

Section: Resultsmentioning

confidence: 99%

“…Only the second MRI scan was missing for P1. These images are centered on the only cluster output from the ALE meta-analysis performed in the previous literature review ( Dedry et al, 2022 ), located at [–50, –8, 32] (in MNI coordinates). This coordinate corresponds to the dorsal laryngeal motor control area and more precisely, the ventromedial peak ( Brown et al, 2008 , 2009 ; Belyk et al, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

“…To define the regions of interest (ROI) ( Dedry et al, 2022 ), the present experiment used a previous literature review. This study highlighted 20 left-sided coordinates or clusters of activation and 23 right-sided coordinates or clusters of activation in fifteen different regions in the brain and cerebellum (named according to the atlas of Mai et al, 2006 ).…”

Section: Methodsmentioning

confidence: 99%

“…Therefore, the present study followed three UVFP patients for 1 year with several multiparametric voice assessments and MRI. First, we will comment on the task proposed in this study with regard to our previous review of the literature on activated regions in sustained vowel phonation tasks ( Dedry et al, 2022 ). Second, we will describe the evolution of brain and brainstem activations for this phonation task in three UVFP patients according to time, proposed interventions and vocal and/or nervous recovery.…”

Section: Introductionmentioning

confidence: 99%

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Brain adaptation following various unilateral vocal fold paralysis treatments: A magnetic resonance imaging based longitudinal case series

et al. 2022

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AimExamination of central compensatory mechanisms following peripheral vocal nerve injury and recovery is essential to build knowledge about plasticity of the neural network underlying phonation. The objective of this prospective multiple-cases longitudinal study is to describe brain activity in response to unilateral vocal fold paralysis (UVFP) management and to follow central nervous system adaptation over time in three patients with different nervous and vocal recovery profiles.Materials and methodsParticipants were enrolled within 3 months of the onset of UVFP. Within 1 year of the injury, the first patient did not recover voice or vocal fold mobility despite voice therapy, the second patient recovered voice and mobility in absence of treatment and the third patient recovered voice and vocal fold mobility following an injection augmentation with hyaluronic acid in the paralyzed vocal fold. These different evolutions allowed comparison of individual outcomes according to nervous and vocal recovery. All three patients underwent functional magnetic resonance imaging (fMRI task and resting-state) scans at three (patient 1) or four (patients 2 and 3) time points. The fMRI task included three conditions: a condition of phonation and audition of the sustained [a:] vowel for 3 s, an audition condition of this vowel and a resting condition. Acoustic and aerodynamic measures as well as laryngostroboscopic images and laryngeal electromyographic data were collected.Results and conclusionThis study highlighted for the first time two key findings. First, hyperactivation during the fMRI phonation task was observed at the first time point following the onset of UVFP and this hyperactivation was related to an increase in resting-state connectivity between previoulsy described phonatory regions of interest. Second, for the patient who received an augmentation injection in the paralyzed vocal fold, we subsequently observed a bilateral activation of the voice-related nuclei in the brainstem. This new observation, along with the fact that for this patient the resting-state connectivity between the voice motor/sensory brainstem nuclei and other brain regions of interest correlated with an aerodynamic measure of voice, support the idea that there is a need to investigate whether the neural recovery process can be enhanced by promoting the restoration of proprioceptive feedback.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%