Neural activity of supplementary and primary motor areas in monkeys and its relation to bimanual and unimanual movement sequences

Kazennikov, O. V.; Hyland, Brian I.; Corboz, Michel R.; Babalian, A.; Rouiller, Eric M.; Wiesendanger, M.

doi:10.1016/s0306-4522(98)00348-0

Cited by 110 publications

(74 citation statements)

References 65 publications

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“…The forward and backward interactions among contralateral SMA and M1 found in our results suggested the function integration among the regions to accomplish the motor-related tasks. Moreover, the earlier study on single-cell recording data in monkeys showed that a large majority of SMA neurons exclusively respond to contralateral hand movements only (Grefkes et al, 2008;Kazennikov et al, 1999). Especially, our results specified this effective circuit in contralateral hemisphere, expended the results to the motor imagery condition, and showed similar mechanisms in motor execution and motor imagery.…”

Section: Methodological Considerationssupporting

confidence: 75%

Differential Contribution of Bilateral Supplementary Motor Area to the Effective Connectivity Networks Induced by Task Conditions Using Dynamic Causal Modeling

et al. 2014

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Functional imaging studies have indicated hemispheric asymmetry of activation in bilateral supplementary motor area (SMA) during unimanual motor tasks. However, the hemispherically special roles of bilateral SMAs on primary motor cortex (M1) in the effective connectivity networks (ECN) during lateralized tasks remain unclear. Aiming to study the differential contribution of bilateral SMAs during the motor execution and motor imagery tasks, and the hemispherically asymmetric patterns of ECN among regions involved, the present study used dynamic causal modeling to analyze the functional magnetic resonance imaging data of the unimanual motor execution/imagery tasks in 12 right-handed subjects. Our results demonstrated that distributions of network parameters underlying motor execution and motor imagery were significantly different. The variation was mainly induced by task condition modulations of intrinsic coupling. Particularly, regardless of the performing hand, the task input modulations of intrinsic coupling from the contralateral SMA to contralateral M1 were positive during motor execution, while varied to be negative during motor imagery. The results suggested that the inhibitive modulation suppressed the overt movement during motor imagery. In addition, the left SMA also helped accomplishing left hand tasks through task input modulation of left SMA/right SMA connection, implying that hemispheric recruitment occurred when performing nondominant hand tasks. The results specified differential and altered contributions of bilateral SMAs to the ECN during unimanual motor execution and motor imagery, and highlighted the contributions induced by the task input of motor execution/imagery.

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Section: Methodological Considerationssupporting

confidence: 75%

Differential Contribution of Bilateral Supplementary Motor Area to the Effective Connectivity Networks Induced by Task Conditions Using Dynamic Causal Modeling

et al. 2014

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“…Cisek et al (2003) reported similar findings in MI, where movementrelated activity was observed using a task with whole-arm reaching movements that mainly involved the proximal arm. Ipsilateral MI cells were active much more frequently during proximal limb movements, especially when bimanual movements were performed (Donchin et al 1998;Kazennikov et al 1999;Kermadi et al 1998). These reports support the view of Brinkman and Kuypers (1973) that the ipsilateral MI plays a role in the control of the arm, but not of distal hand and finger movements.…”

Section: Comparison Of Neuronal Activity With Previous Studiessupporting

confidence: 72%

Conditional Selection of Contra- and Ipsilateral Forelimb Movements by the Dorsal Premotor Cortex in Monkeys

Kurata

2010

Journal of Neurophysiology

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Kurata K. Conditional selection of contra-and ipsilateral forelimb movements by the dorsal premotor cortex in monkeys. J Neurophysiol 103: 262-277, 2010. First published November 4, 2009 doi:10.1152/jn.91241.2008. It has been suggested that the dorsal premotor cortex (PMd) may contribute to conditional motor behavior. Thus when a selection is instructed by arbitrary conditional cues, it is possible that the unilateral PMd affects behavior, regardless of which arm, contra-or ipsilateral, is to be used. We examined this possibility by recording neuronal activity and injecting muscimol into the caudal PMd (PMdc) of monkeys while they were performing a reaching task toward visuospatial targets with either the right or left arm, as instructed by low-frequency or high-frequency tone signals. Following the injection of a small amount of muscimol (1 L; 5 g/L) into the unilateral PMdc, monkeys exhibited two major deficits in behavioral performance: 1) erroneous selection of the arm not indicated by the instruction (selection errors) and 2) no movement initiation in response to a visuospatial target cue serving as a trigger signal for reaching within the reaction time limit (movement initiation errors). Errors were observed following unilateral muscimol injection into both right and left PMdc, although selection errors occurred with significantly greater frequency in the arm contralateral to the injection site. By contrast, movement initiation errors were more commonly observed in left-arm trials, regardless of whether the right or left PMdc was inactivated. Notably, errors rarely occurred following a ventral PM muscimol injection. These results suggest that the left and right PMdc cooperate to transform conditional sensory cues into appropriate motor output and can affect both contra-and ipsilateral body movement.

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“…All of them became activated to varying degrees during bimanual and unimanual movements. This would suggest that they are not specific for bimanual coordination, but represent parts of a wider motor network, which can be involved during both uni-and bimanual movements (see also Kazennikov 1998Kazennikov , 1999. Nevertheless, their anatomical location close to the midline may predetermine them to control some of those aspects of movements which are especially important for the coordination of both hands.…”

Section: Medial Wall Areas and Bimanual Coordinationmentioning

confidence: 99%

“…This preservation of "goal invariance" in conjunction with neuronal recording data (Kazennikov et al 1999) led the authors to conclude that the SMA is clearly engaged in bimanual tasks, but does not represent the bimanual command structure.…”

Section: Introductionmentioning

confidence: 98%

Cerebral midline structures in bimanual coordination

Stephan

Binkofski

Posse

et al. 1999

Experimental Brain Research

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In six healthy right-handed volunteers, we compared the cerebral activation pattern related to unimanual right-and left-hand movements and to bimanual in-phase and anti-phase movements using functional magnetic resonance imaging (fMRI). Internally paced unimanual finger-to-thumb opposition movements led to a strong contralateral activation of primary sensorimotor areas in all six subjects. Midline activity was lateralized to the left side during right-hand movements, but to both sides during left-hand movements. Activity patterns of bimanual in-phase movements resembled the combined activity patterns of the two unimanual conditions: right and left hemispheric activations of the primary sensorimotor cortices and predominantly left-sided medial frontal activity. In contrast, during anti-phase movements, we observed a clear increase in activity, in both right and left frontal midline areas and in right hemispheric, mainly dorsolateral premotor areas compared to in-phase movements. These results indicate that frontal midline activity is not specific for bimanual movements per se. It can already be involved during simple unimanual movements but becomes progressively more involved during more complex aspects of movement control.

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Neural activity of supplementary and primary motor areas in monkeys and its relation to bimanual and unimanual movement sequences

Cited by 110 publications

References 65 publications

Differential Contribution of Bilateral Supplementary Motor Area to the Effective Connectivity Networks Induced by Task Conditions Using Dynamic Causal Modeling

Differential Contribution of Bilateral Supplementary Motor Area to the Effective Connectivity Networks Induced by Task Conditions Using Dynamic Causal Modeling

Conditional Selection of Contra- and Ipsilateral Forelimb Movements by the Dorsal Premotor Cortex in Monkeys

Cerebral midline structures in bimanual coordination

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