Neue Synthese von Chinolinderivaten

Knorr, Ludwig

doi:10.1002/cber.188301602193

Cited by 19 publications

(17 citation statements)

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“…Over the past decade, the most classical methods for the synthesis of pyrazoles were the Knorr condensation of 1,3‐diketones with hydrazine (Scheme ‐1) . Another important method was the 1,3‐dipolar cycloaddition of hydrazones with olefins or alkynes .…”

Section: Methodsmentioning

confidence: 99%

Cobalt and Copper Co–Catalyzed Three‐Component Reactions for the Synthesis of 1,3,4‐Trisubstituted Pyrazoles

Wei

Zhou

et al. 2017

ChemistrySelect

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Section: Methodsmentioning

confidence: 99%

Cobalt and Copper Co–Catalyzed Three‐Component Reactions for the Synthesis of 1,3,4‐Trisubstituted Pyrazoles

Wei

Zhou

et al. 2017

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“…General Procedure: Preparation of Substituted 2-Methylquinolin-4(1H)-ones using Biphenyl ether as a cyclisation agent [4][5][6][7] Quinolin-4(1H)-ones were prepared by using one of the standard procedures for Conrad-Limpach reaction. An oven-dry 100mL round-bottom flask attached to a Dean-Stark trap equipped with a reflux condenser was charged with a substituted aniline (0.25mol), ethyl acetoacetate (0.25mol), benzene (25 mL), and glacial acidic acid (1 mL).…”

Section: Methodsmentioning

confidence: 99%

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2014

IJPSR

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ABSTRACT:In the present work various conventional methods and microwave method for synthesis of substituted quinolone reported. Substituted anilines were taken as a starting material and reacted with ethyl acetoacetate in presence of catalytic amount of acid and cyclized by various cyclisation agents that give the title compounds which differ in its color intensity, reaction time as well in %yield. Based on results we obtain, it has been concluded that microwave method for synthesis of substituted quinolone is more convenient in terms of reaction time and use of solvent.

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“…1883 年, Knorr [24] 报道了取代的 1,3-二羰基化合物和肼反应生成 1,3,5-三取代的吡唑. 该反应由于区域选择性不好, 会生成两种取代基位置不同的异构体 1 和 2 (Eq.…”

Section: 由 13-二羰基化合物及类似物合成吡唑unclassified

Recent Progress in Synthesis of Polysubstituted Pyrazoles

Wang¹,

Zhang²,

Chen³

et al. 2020

Chin. J. Org. Chem.

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Pyrazole, an important class of nitrogen-containing five-member hetrocyclic compounds, widely exists in natural products, bio-active molecules and drugs, and it is also a valuable intermediate in organic synthesis. The synthesis of polysubstituted pyrazoles has attracted much attention and developed rapidly in recent years. Herein, the recent research progress in the construction of polysubstituted pyrazoles is summarized. Keywords pyrazole; synthesis; research process 含氮杂环类结构单元作为基础的杂环, 广泛存在于天然产物、药物及功能材料中 [1～5] , 对于现代药物化学和有机化学有着非常重要的作用. 正是由于上述原因, 发展含氮杂环类化合物的高效合成方法一直是有机化学家和药物化学家们研究的热点 [6～10]. 在众多的含氮杂环中, 吡唑是重要的成员之一, 作为关键的结构单元, 广泛存在于许多药物和生物活性分子中(图 1), 如具有止痛 [11] 、退热 [12] 、抗炎 [13] 、抗菌 [14] 和抗高血糖 [15] 等药用活性分子. 很多已成为市售药品, 具有代表性的有塞来昔布(celecoxib) [16] 、吗伐烤昔(mavacoxib) [17] 、雷扎沙班(razaxaban) [18,19] 等(图 1). 随着对吡唑类化合物合成及其临床应用研究的深入, 近年来科研工作者也发展出很多含吡唑结构的生物活性分子, 如 p38 激酶抑制剂 [20] 、大麻素 1 型受体拮抗剂 [21] 、抗 HIV 病毒试剂 [22] 和细胞周期检测点激酶抑制剂(CHK1) [23] 等.

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Neue Synthese von Chinolinderivaten

Cited by 19 publications

References 0 publications

Cobalt and Copper Co–Catalyzed Three‐Component Reactions for the Synthesis of 1,3,4‐Trisubstituted Pyrazoles

Cobalt and Copper Co–Catalyzed Three‐Component Reactions for the Synthesis of 1,3,4‐Trisubstituted Pyrazoles

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Recent Progress in Synthesis of Polysubstituted Pyrazoles

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