Networks of nanotubes and containers

Karlsson, Roger; Karlsson, Mattias; Cans, Ann-Sofie; Strömberg, Anette; Ryttsén, Frida; Orwar, Owe

doi:10.1038/35051656

Cited by 258 publications

(266 citation statements)

References 10 publications

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“…73,75,77 Such situation can only be realized in a confined attoliter volume. Potential medical and biological applications using self-assembled LNTs and polymer nanotubes are gradually in progress, including controlled drug release, 82 gene delivery, 83 cell adhesion, 84 antimicrobial activity, 85 helical crystallization of proteins, 86 and biomolecule sensing.…”

Section: Future Aspectsmentioning

confidence: 99%

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Self‐assembled organic nanotubes: Toward attoliter chemistry

Shimizu

2008

J. Polym. Sci. A Polym. Chem.

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Diverse chemical functionalization of the inner and outer surfaces of the nanotubes enables us to sense and visualize the encapsulation and transport behavior of biomacromolecular guests. The event occurs specifically in attoliter volume nanospace inside the hollow cylinder of the nanotubes. Comparison of the organic nanotube history with that of well‐known carbon nanotubes and a variety of molecular building blocks as tube‐forming compounds were first introduced. Asymmetric organic nanotubes with different inner and outer surfaces were discussed in terms of molecular design, immobilization of functional moieties, and molecular packing. Finally, the practical examples of the organic nanotubes as a nanocontainer, nanochannel, and nanopipette were also described to feature the concept of “attoliter chemistry.” © 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 2601–2611, 2008

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Section: Future Aspectsmentioning

confidence: 99%

“…72 Following this micromanipulation protocols for the LNT, Orwar and coworkers recently developed a new electroinjection technique. [73][74][75] In this system, the LNTs interconnect fluid-state phospholipid bilayer vesicles to form nanotube-vesicle networks with high geometrical complexity.…”

Section: Restricted Diffusion Of Biomacromolecular Guests In a Nanochmentioning

confidence: 99%

Self‐assembled organic nanotubes: Toward attoliter chemistry

Shimizu

2008

J. Polym. Sci. A Polym. Chem.

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“…43,44 This limitation has hindered progress in the application of such multicompartment systems in coupled microreactors, 45,46 or complex liposome networks. [47][48][49][50] In this paper, we report on a surfactant-assisted microfluidic strategy for assembling multicompartment liposomes from double emulsions. The key to the successful formation of monodisperse, stable and structured liposomes is control over the dewetting process.…”

mentioning

confidence: 99%

Monodisperse Uni- and Multicompartment Liposomes

Deng¹,

Yelleswarapu²,

Huck³

2016

J. Am. Chem. Soc.

224

228

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Liposomes are self-assembled phospholipid vesicles with great potential in fields ranging from targeted drug delivery to artificial cells. The formation of liposomes using microfluidic techniques has seen considerable progress, but the liposomes formation process itself has not been studied in great detail. As a result, high throughput, high-yielding routes to monodisperse liposomes with multiple compartments have not been demonstrated. Here, we report on a surfactant-assisted microfluidic route to uniform, single bilayer liposomes, ranging from 25 µm to 190 µm, and with or without multiple inner compartments. The key of our method is the precise control over the developing interfacial energies of complex W/O/W emulsion systems during liposome formation, which is achieved via an additional surfactant in the phase. The liposomes consist of single bilayers, as demonstrated by nanopore formation experiments and confocal fluoresce microscopy, and they can act as compartments for cell-free gene expression. The microfluidic technique can be expanded to create liposomes with a multitude of coupled compartments, opening routes to networks of multistep microreactors.There has been a significant interest in the use of liposomes, self-assembled phospholipid vesicles composed of bilayer membranes, in fields as diverse as targeted drug delivery, 1,2 membrane protein science, 3-5 bioreactors 6-8 and biosensors. 9,10 Cell-sized liposomes that encapsulate biomolecules and incorporate biological functions provide a versatile mimic of certain aspects of living cells, as exemplified by work showing RNA replication, [11][12][13] in vitro transcription and translation of gene networks, 6,14-16 and organization of cell division machinery in liposomes. [17][18][19][20][21][22][23][24]

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“…Various experimental techniques are now available to control the geometry, dimensionality, topology, and functionality in surfactant membranes (12)(13)(14)(15)(16)(17)(18)(19). Methods based on self-assembly, selforganization, forced shape transformations, and micromanipulation are used to form synthetic or semisynthetic enclosed lipid bilayer structures with some properties similar to biological compartments.…”

Section: Forming Nanotube-vesicle Networkmentioning

confidence: 99%

“…Our lab and other groups have developed concepts and protocols for producing nanoscale devices and networks based on spontaneous and forced shape transitions in lipid bilayer membranes or other soft materials (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22). The networks consist of surface-immobilized vesicles (~5-50-µm diam) conjugated by nanotubes (50 -150-nm radius).…”

mentioning

confidence: 99%

Chemical Analysis in Nanoscale Surfactant Networks

Karlsson¹,

Ewing²,

Dommersnes³

et al. 2006

Anal. Chem.

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A lthough the "hard matter" physical sciences (e.g., microelectronics) and the "soft matter" biological sciences (e.g. cell biology and molecular biology) are two distinct areas of research, they are now progressively being combined to create new systems and devices with applications in analytical chemistry. Miniaturization is one of the important factors here: A major goal is to create devices that can operate with high sensitivity and resolution on length scales and time frames relevant to single-molecule studies. Using top-down strategies to fabricate ultrasmall structures is technologically challenging. Therefore, new bottom-up methods of nanoscale fabrication based on self-assembly and self-organization of biological or biomimetic materials are constantly being developed (1-6). The type of nanoscale engineering described in this article has, at least partly, been derived from our growing understanding of living cells, where many nanomechanical and chemical operations are based on controlled shape transitions in surfactant bilayer membranes that also carry proteins to support important functions. Biological cells have a staggering ability to parallel-process multiple chemical reactions and physical (e.g., transport) processes in nanometer-sized systems and to perform a great number of tasks based on single-molecule processes. Thus, nature has solved many engineering problems on small length scales and achieved truly nanoscale, complex chemical devices that can be used for computational, biophysical, synthetic, and analytical applications (7-11). The philosophy behind the work reviewed here is to produce human-made, biomimetic systems that imitate some key features of small biological systems with the overall goal of providing micro-and nanoscale devices that can perform complex chemical operations.

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Networks of nanotubes and containers

Cited by 258 publications

References 10 publications

Self‐assembled organic nanotubes: Toward attoliter chemistry

Self‐assembled organic nanotubes: Toward attoliter chemistry

Monodisperse Uni- and Multicompartment Liposomes

Chemical Analysis in Nanoscale Surfactant Networks

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