2020
DOI: 10.3389/fmolb.2020.590045
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Abstract: Alzheimer's disease (AD) is the leading cause of dementia and one of the most common causes of death worldwide. As an age-dependent multifactorial disease, the causative triggers of AD are rooted in spontaneous declines in cellular function and metabolic capacity with increases in protein stressors such as the tau protein. This multitude of age-related processes that cause neurons to change from healthy states to ones vulnerable to the damage seen in AD are difficult to simultaneously investigate and even more… Show more

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Cited by 3 publications
(2 citation statements)
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References 90 publications
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“…The T102C polymorphism of the 5-HT2A receptor gene is a possible risk factor for the development of neuropsychiatric symptoms [50,51]. Neurodegeneration and aging not only alter pain processing [52] but also enhance neuronal vulnerability and aberrant responsiveness to stress pathways [53,54] because of abnormal neuronal and synaptic plasticity that occur in depression and AD through inflammaging [55]. Aging and neurodegeneration induce primed microglia to produce proinflammatory cytokines [56,57] and decrease the levels of brain-derived neurotrophic factor (BDNF) responsible for neurogenesis [58].…”
Section: Management Of Pain and Neuropsychiatric Symptoms Through Neu...mentioning
confidence: 99%
“…The T102C polymorphism of the 5-HT2A receptor gene is a possible risk factor for the development of neuropsychiatric symptoms [50,51]. Neurodegeneration and aging not only alter pain processing [52] but also enhance neuronal vulnerability and aberrant responsiveness to stress pathways [53,54] because of abnormal neuronal and synaptic plasticity that occur in depression and AD through inflammaging [55]. Aging and neurodegeneration induce primed microglia to produce proinflammatory cytokines [56,57] and decrease the levels of brain-derived neurotrophic factor (BDNF) responsible for neurogenesis [58].…”
Section: Management Of Pain and Neuropsychiatric Symptoms Through Neu...mentioning
confidence: 99%
“…Normally, when proteins misfold, cellular translational control pathways-such as the UPR and protein chaperones -attempt to correct the issue by either correctly refolding them or degrading them. However, due to the exponential nature of AD and the typical degradation of cells in an aging organism, misfolded proteins are able to accumulate, degrading neurological function (Clark, 2004;Hoffman et al, 2020;Reynaud, 2010;Zheng et al, 2013).…”
Section: Introductionmentioning
confidence: 99%