Network Meta-Analysis of Chinese Herbal Injections Plus the FOLFOX Regimen for the Treatment of Colorectal Cancer in China

Zhang, Dan; Wu, Jiarui; Duan, Xiaojiao; Wang, Kaihuan; Ni, Mengwei; Zhang, Xiaomeng; Zhang, Bing; Zhao, Yi

doi:10.1177/1534735419827098

Cited by 21 publications

(24 citation statements)

References 56 publications

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“…[ 20 , 22 , 34 ] In recent years, KLT injection has been widely used in the treatment of colorectal cancer, with significant efficacy. [ 35 ] Yet the evidence from the RCTs is inconsistent. With the increasing number of clinical trials, it is urgent to systematically evaluate the efficacy of KLT injection in the treatment of colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of Kanglaite injection combined with chemotherapy for colorectal cancer

et al. 2020

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Background: The incidence and mortality of colorectal cancer are high. Chemotherapy is currently the commonly used therapeutic scheme, but there are drug resistance and toxic and side effects. Kanglaite (KLT) injection is a broad-spectrum anticancer drug extracted from Semen Coicis (Yi Yi Ren) , which has been widely used in the treatment of colorectal cancer. Clinical practice shows that KLT injection combined with chemotherapy has certain therapeutic advantages, but there is a lacking of evidence of evidence-based medicine. The purpose of this study is to systematically investigate the efficacy and safety of KLT injection combined with chemotherapy in the treatment of colorectal cancer. Methods: Randomized controlled trials of KLT injection combined with chemotherapy in the treatment of colorectal cancer were retrieved from English databases (PubMed, Embase, Web of Science, the Cochrane Library) and Chinese databases (China National Knowledge Infrastructure, Wanfang, Chongqing VIP Chinese Science and Technology Periodical Database, Chinese Biological and Medical database), as well as searching Baidu academic and Google academic manually, and the retrieval time was from their establishment to August 2020. Two researchers independently conducted data extraction and literature quality evaluation on the quality of the included literatures, and meta-analysis was conducted on the included literatures using RevMan 5.3 (developed by the UK's International Cochrane Collaboration). Results: This study assessed the efficacy and safety of KLT injection combined with chemotherapy in the treatment of colorectal cancer by effective rate, Karnofsky Performance Status, Carcinoemybryonic Angtigen remission rate, pain remission rate, and incidence of adverse reactions etc. Conclusions: This study will provide reliable evidence-based evidence for the clinical application of KLT injection combined with chemotherapy in the treatment of colorectal cancer. Ethics and dissemination: The private information from individuals will not be published. This systematic review also will not involve endangering participant rights. Ethical approval is not required. The results may be published in a peer-reviewed journal or disseminated in relevant conferences. OSF Registration number: DOI 10.17605/OSF.IO/EKVAF

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Section: Discussionmentioning

confidence: 99%

Efficacy and safety of Kanglaite injection combined with chemotherapy for colorectal cancer

et al. 2020

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“…and irinotecan, which are combined in clinical practice [2], but treatment is difficult if resistance occurs [18]. Traditional Chinese medicine is expected to be an ideal agent for reversing MDR after the failure of chemotherapy for tumours due to its low toxicity, good stability, and unique effects [8,9,19]. In fact, identification of a Chinese medicine preparation that is sensitive, reduces toxicity, shows synergistic and complementary effects with drugs, and reduces drug resistance is urgently needed.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, studies to date have shown the potential for the development of traditional Chinese medicine to treat tumour MDR. Compound radix Sophorae injection is a traditional Chinese medicine that exerts antioxidant effects, protects the liver, enhances immunity, and provides chemotherapeutic sensitivity [9][10][11]. e injection is prepared from extracts of radix Sophora flavescens, poriacocoscocos, and pachycocoscocos, and the main effective components are oxymatrine, sophorine, and matrine.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Compound Sophora on Fluorouracil and Oxaliplatin Resistance in Colorectal Cancer Cells

Zhong

Fan

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Fluorouracil (5-FU) and oxaliplatin (L-OHP) are the most commonly used chemotherapy drugs for colorectal cancer, though resistance is common. Compound Sophora injection is a traditional Chinese medicine that can protect the liver against oxidation, improve immunity, and enhance sensitivity to chemotherapy; it may have an effect of reversing resistance in 5-FU- and L-OHP-resistant gastric cancer cells (5-FU/SW480 and L-OHP/SW480, respectively). A concentration gradient experiment was performed to identify a nontoxic dose of compound Sophora injection. 5-FU/SW480 and L-OHP/SW480 cells were treated with the nontoxic dose of compound radix Sophorae injection for 48 h, and changes in drug resistance to 5-FU and L-OHP were detected. Alterations in apoptosis and the cell cycle were assessed, as were the mRNA and protein levels of permeability glycoprotein (P-gp), annexin A1 (ANXA1), and ATP-binding cassette superfamily G member 2 (ABCG2). Flow cytometry showed a reduction in the number of cells in the G1 phase and an increase of cells in the S phase (P<0.05). mRNA and protein expression of P-gp and ABCG2 was significantly higher in 5-FU/SW480 and L-OHP/SW480 cell lines, and ANXA1 expression decreased significantly (P<0.05). Compound Sophora injection can reverse the drug resistance of 5-FU/SW480 and L-OHP/SW480 cell lines to 5-FU and L-OHP, respectively, possibly through a mechanism involving reduced expression of P-gp and ABCG2 but enhanced expression of ANXA1, which is the basis for the identification of clinical drug resistance in colorectal cancer.

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“…In this context, this study included 8 DSCIs, namely, Danshen injection (DS), Fufang Danshen injection (FFDS), Danhong injection (DH), Dansenduofensuanyan injection (DSDFSY), Danshen Salvianolic Acids injection (DSSA), Danshenchuanxiongqin injection (DSCXQ), Sodium Tanshinone IIA Sulfonate injection (STS) and Guanxinning injection (GXN). Compared with the traditional double-arm meta-analysis, network meta-analysis (NMA) can synthesize different interventions for the same disease and perform direct or indirect comparisons ( Grant, 2019 ; Sun et al, 2019 ; Zhang et al, 2019 ). Moreover, NMA can assist assessing and ranking the therapeutic effects of different treatments ( Rouse et al, 2017 ; Pan et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Comparative Efficacy of Danshen Class Injections for Treating Acute Coronary Syndrome: A Multidimensional Bayesian Network Meta-Analysis of Randomized Controlled Trials

Guo

et al. 2020

Front. Pharmacol.

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Background Acute coronary syndrome, that is a common and serious cardiovascular disease, imposes a huge economic burden on global public health. And Danshen class injections are commonly used in the treatment of acute coronary syndrome in China. Thus, the Bayesian network meta-analysis was devised to investigate the efficacy of different Danshen class injections against acute coronary syndrome. Methods Eligible inclusion and exclusion criteria were established in advance. Then, a systematic literature search was performed in several databases from inception to February 2020. Further, the included randomized controlled trials data were adopted to calculation, prepare graphs and multidimensional cluster analysis by WinBUGS 1.4.3, Stata V.13.0 and R 3.6.1 software, respectively. Results A total of 53 eligible randomized controlled trial studies with 6401 patients were obtained that evaluated the clinical effectiveness rate, the level of hypersensitive C-reactive protein, C-reactive protein, interleukin-6, fibrinogen, and adverse reactions after the application of Danshen class injections plus western medicine. Compared with western medicine alone, Danshen class injections combined with western medicine therapy were associated with significantly improved the therapeutic effect. In addition, the results of the multidimensional cluster analysis demonstrated that Danhong injection + western medicine and Danshen injection + western medicine had better therapeutic effects. However, since most eligible randomized controlled trial studies did not focus on the monitoring of adverse reactions, the safety of these Chinese herbal injections needs to be further explored. Conclusion Based on this Bayesian network meta-analysis results, Danhong injection + western medicine and Danshen injection + western medicine might have a better impact on acute coronary syndrome patients. Nevertheless, more large samples, high-quality clinical and multicenter randomized controlled trial studies should be tested and verified in the future.

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Network Meta-Analysis of Chinese Herbal Injections Plus the FOLFOX Regimen for the Treatment of Colorectal Cancer in China

Cited by 21 publications

References 56 publications

Efficacy and safety of Kanglaite injection combined with chemotherapy for colorectal cancer

Efficacy and safety of Kanglaite injection combined with chemotherapy for colorectal cancer

The Effect of Compound Sophora on Fluorouracil and Oxaliplatin Resistance in Colorectal Cancer Cells

Comparative Efficacy of Danshen Class Injections for Treating Acute Coronary Syndrome: A Multidimensional Bayesian Network Meta-Analysis of Randomized Controlled Trials

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