Nestin expression as an independent indicator of poor prognosis for patients with anaplastic thyroid cancer

Kurata, K.; Onoda, Naoyoshi; Noda, Shinichi; Kashiwagi, Shinichiro; Asano, Yuka; Kawajiri, Hidemi; Takashima, Tsutomu; Tanaka, Sayaka; Ohsawa, Masahiko; Hirakawa, Kosei

doi:10.3892/ol.2015.3366

Cited by 5 publications

(2 citation statements)

References 25 publications

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“…As one of the undifferentiated human carcinomas, ATC is causes frequent mortality; patients diagnosed with ATC exhibit a mean survival of ~6 months (1). ATC is aggressive and characterized by highly invasive behavior and early distant metastasis (19). The 5-year survival rate of ATC has been reported to be <5% (2).…”

Section: Discussionmentioning

confidence: 99%

Emodin suppresses angiogenesis and metastasis in anaplastic thyroid cancer by affecting TRAF6‑mediated pathways in�vivo and in�vitro

Shi

Zhou

2018

Mol Med Report

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Emodin has been recognized to be an anti-cancer agent against a number of types of human cancer. It was demonstrated that TNF receptor-associated factor 6 (TRAF6) was correlated with cancer angiogenesis and metastasis. The present study confirmed the association between TRAF6 and the angiogenesis/metastasis of anaplastic thyroid cancer (ATC). The anti-angiogenesis and metastatic effects of emodin, in addition to its molecular mechanisms in ATC, were investigated. A total of two ATC cell lines, namely 8505c and SW1736, were studied. ATC cells were implanted into nude mice to form xenografts or to establish lung metastasis models. Emodin was used to incubate ATC cells or to treat animals orally. An MTT assay was used to assess cell proliferation. A wound healing assay was employed to evaluate cell migration. ELISA analysis was used to detect the vascular endothelial growth factor (VEGF) content. Western blotting was used to determine the protein expression levels. In the in vivo study, cancer angiogenesis was assessed by micro vascular density measurement. The lung metastatic rate was the criterion for cancer metastasis. The results of the present study demonstrated that the proliferation of ATC was inhibited by emodin. The activation of the TRAF6/hypoxia inducible factor (HIF)-1α/VEGF and TRAF6/basigin (CD147)/matrix metalloproteinase-9 (MMP9) pathways were associated with the angiogenesis and metastasis of ATC. In a concentration-dependent manner, emodin inhibited the TRAF6/HIF-1α/VEGF and TRAF6/CD147/MMP9 signaling pathways to suppress angiogenesis and metastasis. In conclusion, emodin exerted anti-angiogenic and anti-metastatic activities in ATC by affecting TRAF6-mediated pathways.

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Section: Discussionmentioning

confidence: 99%

Emodin suppresses angiogenesis and metastasis in anaplastic thyroid cancer by affecting TRAF6‑mediated pathways in�vivo and in�vitro

Shi

Zhou

2018

Mol Med Report

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“…Observations in several malignancies suggest that nestin may serve as a central organizer of important processes for cancer behavior. Nestin expression in tumor tissue has been associated with the degree of tumor differentiation and proliferation, the invasive and metastatic capacities of tumors and/or the degree of neoangiogenesis [ 60 , 61 , 62 ].…”

Section: Nestin-expressing Cells In Lung Cancermentioning

confidence: 99%

Nestin-Expressing Cells in the Lung: The Bad and the Good Parts

Jaramillo‐Rangel

Chávez-Briones

Ancer-Arellano

et al. 2021

Cells

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Nestin is a member of the intermediate filament family, which is expressed in a variety of stem or progenitor cells as well as in several types of malignancies. Nestin might be involved in tissue homeostasis or repair, but its expression has also been associated with processes that lead to a poor prognosis in various types of cancer. In this article, we review the literature related to the effect of nestin expression in the lung. According to most of the reports in the literature, nestin expression in lung cancer leads to an aggressive phenotype and resistance to chemotherapy as well as radiation treatments due to the upregulation of phenomena such as cell proliferation, angiogenesis, and metastasis. Furthermore, nestin may be involved in the pathogenesis of some non-cancer-related lung diseases. On the other hand, evidence also indicates that nestin-positive cells may have a role in lung homeostasis and be capable of generating various types of lung tissues. More research is necessary to establish the true value of nestin expression as a prognostic factor and therapeutic target in lung cancer in addition to its usefulness in therapeutic approaches for pulmonary diseases.

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The expression of P-glycoprotein in leukemia cells is associated with the upregulated expression of nestin, a class 6 filament protein

et al. 2016

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Nestin expression as an independent indicator of poor prognosis for patients with anaplastic thyroid cancer

Cited by 5 publications

References 25 publications

Emodin suppresses angiogenesis and metastasis in anaplastic thyroid cancer by affecting TRAF6‑mediated pathways in�vivo and in�vitro

Emodin suppresses angiogenesis and metastasis in anaplastic thyroid cancer by affecting TRAF6‑mediated pathways in�vivo and in�vitro

Nestin-Expressing Cells in the Lung: The Bad and the Good Parts

The expression of P-glycoprotein in leukemia cells is associated with the upregulated expression of nestin, a class 6 filament protein

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