Study Design
Subgroup analysis of the lumbar spinal stenosis without degenerative spondylolisthesis (LSS) diagnostic cohort of the Spine Patient Outcomes Research Trial multi-center randomized clinical trial with a concurrent observational cohort.
Objective
To determine if sedimentation sign on MRI can help with LSS treatment decisions
Summary of Background Data
LSS is one of the most common reasons for surgery in the US elderly, but there is a dearth of reliable diagnostic tools that give a clear indication for surgery. Recent studies have suggested that positive sedimentation sign on MRI may be a possible prognostic indicator.
Methods
All LSS patients in both the randomized and observational cohorts had imaging-confirmed stenosis, were surgical candidates, and had neurogenic claudication for at least 12 weeks prior to enrollment. Patients were categorized “mild”, “moderate” or “severe” for stenosis severity. Of the 654 LSS patients enrolled in SPORT, 115 had complete T2-weighted axial and sagittal digitized images available for retrospective review. An independent orthopaedic spine surgeon evaluated these de-identified DICOM files for the sedimentation sign.
Results
Sixty-six percent (76/115) of patients were found to have a positive sedimentation sign. Those with a positive sedimentation sign were more likely to have stenosis at L2-L3 (33% vs. 10% p=0.016) or L3-L4 76% vs. 51%, p=0.012), and to have severe (72% vs. 33%, p<0.0001) central stenosis (93% vs. 67% p<0.001) at two or more concurrent levels (57% vs. 18%, p=0.01). In multivariate models, the surgical treatment effect was significantly larger in the positive sedimentation sign group for ODI (−16 vs. −7; p=0.02).
Conclusions
A positive sedimentation sign was associated with a small but significantly greater surgical treatment effect for ODI in patients with symptomatic LSS, after adjusting for other demographic and imaging features. These findings suggest that positive sedimentation sign may potentially be a useful adjunct to help guide an informed treatment choice regarding surgery for LSS.