volume 192, issue 7, P3345-3354 2014
DOI: 10.4049/jimmunol.1300825
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Giusi Prencipe, Gaetana Minnone, Raffaele Strippoli, Loredana De Pasquale, Stefania Petrini, Ivan Caiello, Luigi Manni, Fabrizio De Benedetti, Luisa Bracci-Laudiero

Abstract: Nerve growth factor (NGF) levels are highly increased in inflamed tissues, but their role is unclear. We show that NGF is part of a regulatory loop in monocytes: inflammatory stimuli, while activating a proinflammatory response through TLRs, upregulate the expression of the NGF receptor TrkA. In turn, NGF, by binding to TrkA, interferes with TLR responses. In TLR-activated monocytes, NGF reduces inflammatory cytokine production (IL-1β, TNF-α, IL-6, and IL-8) while inducing the release of anti-inflammatory medi…

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