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Cited by 372 publications
(207 citation statements)
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References 70 publications
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“…However, the global effect of ISD on the immune system predisposes patients to the development of infection and cancer [1] and may have deleterious long-term effects on graft function [2]. Ideally, the goal of immunosuppressive therapy would be the induction of long-lasting immunological tolerance by selective deletion of antigen-specific and autoaggressive lymphocytes.…”
Section: Introductionmentioning
confidence: 99%
“…However, the global effect of ISD on the immune system predisposes patients to the development of infection and cancer [1] and may have deleterious long-term effects on graft function [2]. Ideally, the goal of immunosuppressive therapy would be the induction of long-lasting immunological tolerance by selective deletion of antigen-specific and autoaggressive lymphocytes.…”
Section: Introductionmentioning
confidence: 99%
“…THE INTRODUCTION OF cyclosporine A (CsA) into clinical transplantation two decades ago as an immunosuppressive agent to prevent allograft rejection lead to a significant improvement in both allograft half-life and patient survival (16). The immunosuppressive action of CsA is mediated by formation of a complex with cyclophilin, which in turn inhibits the activity of protein phosphatase 2B, calcineurin.…”
mentioning
confidence: 99%
“…For the maintenance of the transplantation, immunosuppressive drugs are needed, with Tacrolimus being one of these. One of the undesirable effects of Tacrolimus is nephrotoxicity (20) . It is believed that one of the mechanisms associated with kidney damage caused by FK506 is the production of reactive oxygen species (ROS) (21) .…”
Section: Discussionmentioning
confidence: 99%