Nephrotoxicity of contrast media and protective effects of acetylcysteine

Briguori, Carlo; Quintavalle, Cristina; Micco, Francesca De; Condorelli, Gerolama

doi:10.1007/s00204-010-0626-5

Cited by 44 publications

(35 citation statements)

References 73 publications

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“…Measurements from all groups are summarized with plots in Fig. Control group readings for each parameter were within the normal range reported in the literature (13). The rats injected with diatrizoate without pretreatment (group CA) had substantial changes in their biochemistry.…”

Section: Resultssupporting

confidence: 67%

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In vivo nephroprotective efficacy of propolis against contrast-induced nephropathy

Baykara

Silici

Özçelik³

et al. 2015

Diagn Interv Radiol

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C ontrast agents are often used in diagnostic imaging or interventional procedures in clinical radiology or nuclear medicine for the purpose of providing contrast enhancement in images. Additional contrast improves the accuracy of detecting pathologic abnormalities in the underlying biological system or the outcome of the intervention. Some of the contrast agents, however, expose the patient to toxic side effects. Diatrizoate is one of those radiocontrast agents used for imaging kidney and its related structures. It has a high-osmolality and contains iodine for absorption of X-rays and hence for producing localized hyperintensities in computed tomography images. In patients with kidney dysfunction, as measured by serum creatinine clearance level of less than 60 mL/min, diatrizoate may lead to kidney failure (1). This effect is called contrast-induced nephropathy (CIN) and constitutes one of the most common causes of hospital-acquired renal failures in clinical practice. Therefore, it is important to develop preventive and/or protective strategies for safeguarding the kidney to be exposed to diatrizoate.Diatrizoate induces kidney damage through a combination of renal ischemia and direct toxic effect on renal tubular cells (2). The mechanism of pathogenesis includes factors such as impaired nitric oxide production, blockade of vasodilation and generation of reactive oxygen species, all promoting oxidative stress. For preventing kidney from acquiring CIN, past attempts were focused on interventions against toxicity and oxidative stress. In this regard, pharmaceuticals N-acetylcystein (NAC) and calpain inhibitor-1 were investigated and determined to be effective (3). As alternative to such man-made pharmaceuticals, natural compounds found in folk medicine have also gained popularity as viable options in health care. The natural product propolis has been explored on various fronts and its therapeutic

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Section: Resultssupporting

confidence: 67%

“…Past studies have demonstrated that pretreatment with NAC and calpain maintains kidney's normal function (13,19). Therefore, in this study, NAC and calpain were used as reference drugs for the novel pretreatment strategy with propolis.…”

Section: Discussionmentioning

confidence: 99%

In vivo nephroprotective efficacy of propolis against contrast-induced nephropathy

Baykara

Silici

Özçelik³

et al. 2015

Diagn Interv Radiol

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“…Thanks to its antioxidant effect, NAC has dose-dependent protective effects against contrastinduced nephrotoxicity (Briguori et al, 2011). NAC can also be used as both a chelating agent for methylmercury (for review see Dodd et al, 2008) and a mucolytic and antiinflammatory agent, with controversial efficacy in patients with exacerbations of chronic obstructive pulmonary disease (Decramer et al, 2005).…”

Section: N-acetylcysteine In Humans: From Acetaminophen Overdose Antimentioning

confidence: 99%

N-Acetylcysteine as a Treatment for Addiction

Murray¹,

Lacoste²,

Belin³

2012

Addictions - From Pathophysiology to Treatment

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“…Nephrotoxicity represents one of the cutting-edge topics of our journal (Francescato et al 2011;Stewart et al 2011a, b;Faiz et al 2011;Briguori et al 2011;Song et al 2011;Abdel-Bakky et al 2011;Liu et al 2011;Chattopadhyay et al 2011). Therefore, the editors are pleased that Antonio C. Santos and colleagues from the University of Sao Paulo in Brazil accepted our invitation of a state of the art review on cisplatin-induced nephrotoxicity and strategies of nephroprotection (Santos et al 2012; this issue).…”

mentioning

confidence: 97%