Nephrotoxicity of borocaptate after short-term administration in rabbits

Synthesis and Comparative Toxicology of a Series of Polyhedral Borane Anion-Substituted Tetraphenyl Porphyrins

“…injections of BSH at doses of 50 mg/kg/dose but not at 25 mg/ kg/dose. 21 In human glioblastoma patients infused with BSH at doses up to 50 mg/kg, no significant acute toxic effects were found in any of 19 blood parameters, including platelets, ALT, and AST. 22 Thus, the published literature supports the idea that BSH at least is rather nontoxic.…”

“…These same researchers found nephrotoxic lesions in rabbits treated by seven daily i.v. injections of BSH at doses of 50 mg/kg/dose but not at 25 mg/kg/dose . In human glioblastoma patients infused with BSH at doses up to 50 mg/kg, no significant acute toxic effects were found in any of 19 blood parameters, including platelets, ALT, and AST .…”

Synthesis and Comparative Toxicology of a Series of Polyhedral Borane Anion-Substituted Tetraphenyl Porphyrins

“…injections of BSH at doses of 50 mg/kg/dose but not at 25 mg/ kg/dose. 21 In human glioblastoma patients infused with BSH at doses up to 50 mg/kg, no significant acute toxic effects were found in any of 19 blood parameters, including platelets, ALT, and AST. 22 Thus, the published literature supports the idea that BSH at least is rather nontoxic.…”

“…These same researchers found nephrotoxic lesions in rabbits treated by seven daily i.v. injections of BSH at doses of 50 mg/kg/dose but not at 25 mg/kg/dose . In human glioblastoma patients infused with BSH at doses up to 50 mg/kg, no significant acute toxic effects were found in any of 19 blood parameters, including platelets, ALT, and AST .…”

Inhibition of mitochondrial cytochrome c oxidase by dicarbanonaborates

“…mercaptododecaborate is used for neutron capture therapy of some brain tumors [4,6]. Nevertheless, the biological effects of various polyborates on cell metabolism have not been completely elucidated in spite of experimental studies demonstrating the high toxicity of some polyborate derivatives [7,8,9,10].…”

Synthesis and Comparative Toxicology of a Series of Polyhedral Borane Anion-Substituted Tetraphenyl Porphyrins

“…injections of BSH at doses of 50 mg/kg/dose but not at 25 mg/ kg/dose. 21 In human glioblastoma patients infused with BSH at doses up to 50 mg/kg, no significant acute toxic effects were found in any of 19 blood parameters, including platelets, ALT, and AST. 22 Thus, the published literature supports the idea that BSH at least is rather nontoxic.…”

“…These same researchers found nephrotoxic lesions in rabbits treated by seven daily i.v. injections of BSH at doses of 50 mg/kg/dose but not at 25 mg/kg/dose . In human glioblastoma patients infused with BSH at doses up to 50 mg/kg, no significant acute toxic effects were found in any of 19 blood parameters, including platelets, ALT, and AST .…”

Inhibition of mitochondrial cytochrome c oxidase by dicarbanonaborates

“…mercaptododecaborate is used for neutron capture therapy of some brain tumors [4,6]. Nevertheless, the biological effects of various polyborates on cell metabolism have not been completely elucidated in spite of experimental studies demonstrating the high toxicity of some polyborate derivatives [7,8,9,10].…”

Synthesis and Comparative Toxicology of a Series of Polyhedral Borane Anion-Substituted Tetraphenyl Porphyrins

“…injections of BSH at doses of 50 mg/kg/dose but not at 25 mg/ kg/dose. 21 In human glioblastoma patients infused with BSH at doses up to 50 mg/kg, no significant acute toxic effects were found in any of 19 blood parameters, including platelets, ALT, and AST. 22 Thus, the published literature supports the idea that BSH at least is rather nontoxic.…”

“…These same researchers found nephrotoxic lesions in rabbits treated by seven daily i.v. injections of BSH at doses of 50 mg/kg/dose but not at 25 mg/kg/dose . In human glioblastoma patients infused with BSH at doses up to 50 mg/kg, no significant acute toxic effects were found in any of 19 blood parameters, including platelets, ALT, and AST .…”

Inhibition of mitochondrial cytochrome c oxidase by dicarbanonaborates

“…mercaptododecaborate is used for neutron capture therapy of some brain tumors [4,6]. Nevertheless, the biological effects of various polyborates on cell metabolism have not been completely elucidated in spite of experimental studies demonstrating the high toxicity of some polyborate derivatives [7,8,9,10].…”