Nephrotic syndrome in Kimura's disease: apropos a case of the glomerular tip lesion in an African-Caribbean male

Loymans, Rik J B; Berend, Kenrick; Martinez, Victoria G. Abreu de; Florquin, Sandrine; Vries, Aiko P. J. de

doi:10.1093/ndtplus/sfq167

Cited by 2 publications

(3 citation statements)

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“…Nephrotic syndrome has been reported as a complication of Kimura's disease, including membranous nephropathy, minimal change disease, diffuse proliferative glomerulonephritis, mesangial proliferative glomerulonephritis and membrane proliferative glomerulonephritis [8], with a few FSGS cases [9][10][11]. Steroid monotherapy has been used for Kimura's disease and FSGS with varying degrees of success [9][10][11][12]. In this case, the patient was steroid-sensitive on remission of eosinophils, eosinophilic peritonitis, lymph nodes and partial remission of renal damage, which was clinically considered to be associated with systematic involvement of Kimura's disease, however without stronger evidence, and needs long-term follow-up.…”

Section: Discussionmentioning

confidence: 99%

Eosinophilic peritonitis and nephrotic syndrome in Kimura’s disease: a case report and literature review

Yang

Song

et al. 2020

BMC Nephrol

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Background: Eosinophilic peritonitis is a relatively rare entity. Kimura's disease is a rare chronic inflammatory disorder of unknown etiology, characterized by subcutaneous nodules mainly in the head and neck region, regional lymphadenopathy and occasional involvement of kidney. There is currently no report of eosinophilic peritonitis in Kimura's disease. Case presentation: A 44-year-old Chinese man presented with abdominal distention, nausea, vomiting and edema in lower limbs for 1 month. Laboratory data showed elevated eosinophils in peripheral blood and ascites, nephrotic syndrome with progressively renal dysfunction, and elevated IgE. Ultrasonography of lymph nodes showed multiple lymphadenopathy in bilateral inguinal regions. Surgical excision was performed for one of the enlarged lymph nodes and histopathology revealed diagnosis of Kimura's disease. Renal biopsy indicated focal segmental glomerulosclerosis (FSGS) and acute tubulointerstitial nephritis with infiltration of eosinophils in renal interstitium. The patient was prescribed with oral prednisolone therapy (30 mg/day), and underwent continuous ambulatory peritoneal dialysis (CAPD). The peripheral and peritoneal eosinophil count decreased rapidly and normalized within 2 days. Forty-five days after prednisolone therapy, partial remission of nephrotic syndrome and decrease of serum creatinine were achieved while peritoneal dialysis dosage had decreased. Inguinal lymph nodes gradually shrunk in size. The overall conditions remain stable afterwards. Conclusions: This rare case highlighted the clinical conundrum of a patient presenting with eosinophilic peritonitis, lymphadenopathy, nephrotic syndrome and renal failure associated with Kimura's disease. The remarkable eosinophilia, pathology of lymph node and kidney, as well as significant response to steroids should guide towards the diagnosis.

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Section: Discussionmentioning

confidence: 99%

Eosinophilic peritonitis and nephrotic syndrome in Kimura’s disease: a case report and literature review

Yang

Song

et al. 2020

BMC Nephrol

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“…The incidence of childhood stroke varies between 1.8 and 13 ⁄ 100 000 in different reports (1)(2)(3)(4). Risk factors commonly associated with this rare condition are cardiac diseases, haematologic and vascular disorders and infection (5)(6)(7)(8). Up to a fourth of ischaemic strokes in children result from cardiac diseases (6).…”

Section: Introductionmentioning

confidence: 99%

“…The renal symptoms can appear both before and after manifestation of cutaneous lesions. The cause of renal involvement occurring in KD remains obscure (3,8). Several treatment modalities for cutaneous and renal symptoms have been proposed, but the efficacy remains unpredictable.…”

Section: Introductionmentioning

confidence: 99%

Maintenance of remission with cyclosporine in paediatric patients with Kimura′s disease – two case reports

et al. 2011

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Nephrotic syndrome in Kimura's disease: apropos a case of the glomerular tip lesion in an African-Caribbean male

Cited by 2 publications

References 13 publications

Eosinophilic peritonitis and nephrotic syndrome in Kimura’s disease: a case report and literature review

Eosinophilic peritonitis and nephrotic syndrome in Kimura’s disease: a case report and literature review

Maintenance of remission with cyclosporine in paediatric patients with Kimura′s disease – two case reports

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