Biochemical Pharmacology volume 81, issue 5, P577-585 2011 DOI: 10.1016/j.bcp.2010.12.005 View full text
Chun-Yin Huang, Chun-Yi Lee, Meng-Yi Chen, Hsiao-Chi Tsai, Horng-Chaung Hsu, Chih-Hsin Tang

Abstract: Osteosarcoma is characterized by a high malignant and metastatic potential. Cyclooxygenase (COX)-2, the inducible isoform of prostaglandin synthase, has been implicated in tumor metastasis. Nephroblastoma overexpressed gene (NOV), also called CCN3, was regulated proliferation and differentiation of cancer cells. However, the effect of NOV on migration activity and COX-2 expression in human osteosarcoma cells is mostly unknown. Here we found that NOV increased the migration and expression of COX-2 in human oste…

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