Nephro and neurotoxicity of calcineurin inhibitors and mechanisms of rejections: A review on tacrolimus and cyclosporin in organ transplantation

Tolou-Ghamari, Zahra

doi:10.5812/jnp.6

Cited by 25 publications

(17 citation statements)

References 38 publications

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“…Indeed, ARF frequently occurs in critically ill patients and is an independent risk factor for poor outcome. The prevention of kidney injury in intensive care remains a great challenge as specific nephroprotective therapies are still lacking (6)(7)(8). Investigations have been attempted to modify the outcome of this disease especially in patients suffering from tubular injury by either ameliorating renal tubular damage or promoting tubular regeneration in the case of acute tubular necrosis.…”

Section: Introductionmentioning

confidence: 99%

Erythropoietin ameliorates genetamicin-induced renal toxicity: A biochemical and histopathological study

et al. 2012

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Background:Investigations have attempted to modify the outcome of tubular injury by either ameliorating renal tubular damage or promoting tubular regeneration in the case of acute tubular necrosis. Objectives: We investigated the protective effect of Eprex an erythropoietin analogue on tubular injury induced by gentamicin (GM). Materials and Methods: Forty male Wistar rats were randomly divided into four groups. In group 1,rats were served as a sham group. In group 2, rats were injected intraperitoneally with 100 mg/kg of GM for 10 consecutive days (positive control group) and then were sacrificed. In group 3, rats received GM for 10 days then Eprex 100U/kg was injected intraperitoneally for the next 10 days and then they were sacrificed at the day 20th. In group 4 rats were injected a combination of GM (80 mg/kg) and Eprex 100U/kg intraperitoneally for 10 days and then were sacrificed. Results: The results indicated that, Eprex prevented the increase in serum creatinine (Cr) and blood urea nitrogen (BUN). The effect of Eprex on damage score, showed that co-administration of GM and Eprex (group 3 and 4) reduced the kidney tissue damage compared to positive control group (P<0.05). This result indicat that Eprex potentially can reduce or prevent the kidney tissue damage. Conclusions: Ameliorative effect of Eprex when the drug was given in combination with GM and also when the drug was applied after GM-induced tubular damage, revealed the renoprotective potency of Eprex. Eprex is a promising drug to prevent or attenuate tubular damage induced by GM or other nephrotoxic agents which act through the same mechanisms as gentamicin.

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Section: Introductionmentioning

confidence: 99%

Erythropoietin ameliorates genetamicin-induced renal toxicity: A biochemical and histopathological study

et al. 2012

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“…Within this population spiritual believing could improve heart rate and the ability of immune system to fight against the attack in such conditions. Indeed, God is with the patient with those who have believed, seek help through patience and entreaty [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. Spirituality believing by patients could lead to better care.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding to organ transplantation, the legendary and symbolic uses of the different parts of body in texts and paintings continue a fairly unknown topic. Previous publications reported that organ donation could be described as the manifestation of the love of our neighbor [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. A recent study performed in 5360 deceased confirmed that in order to prevent worse outcome in critically ill patients admitted to hospitals, quality of care need to be upgrading [20].…”

Section: Introductionmentioning

confidence: 99%

Spirituality Believing in End Stage Diseases Such as; Genito-Urinary Cancers, Multiple Sclerosis, Recipients of Liver, Kidney or Heart Transplantations

Tolou-Ghamari¹

2017

Foc Sci

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Background: Attention to spirituality could be a good way of communication, phenomenon and definitive evidence in order to commemoration of God compassionate. In such events praise of God compassionate could be a guide to recognize secret alternatives to healing approach connected to dissimilar phases of diseases. By considering in heart and compassionate performing, medical staffs are stimulated to follow therapy, management and advocates to save life and to relief others. Objectives: The aim of this review was to bring the importance of attention to spirituality believing of patients by commemoration of God in events that pharmacotherapy or surgical attempts could not able to lead toward satisfied outcome. Methods: 3830 patients with diagnosed neurologic disorders, 743 kidney recipients and 100 liver recipients were studied. The key words relevant to topic of study were searched through DOAJ, Google Scholar, Pubmed, and Web of Science.

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“…In which, the history of transplantation and viewpoints from the ancient time, especially in the renal transplantation has been reviewed (1). Following this paper, taking a new look from Holy Quran in renal transplantation seems of utmost importance.…”

Section: Dear Editormentioning

confidence: 99%

Non-monetary renal transplantation: An old issue and a new look from Holy Quran

Baradaran‐Ghahfarokhi¹

2012

J Nephropathol

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Nephro and neurotoxicity of calcineurin inhibitors and mechanisms of rejections: A review on tacrolimus and cyclosporin in organ transplantation

Cited by 25 publications

References 38 publications

Erythropoietin ameliorates genetamicin-induced renal toxicity: A biochemical and histopathological study

Erythropoietin ameliorates genetamicin-induced renal toxicity: A biochemical and histopathological study

Spirituality Believing in End Stage Diseases Such as; Genito-Urinary Cancers, Multiple Sclerosis, Recipients of Liver, Kidney or Heart Transplantations

Non-monetary renal transplantation: An old issue and a new look from Holy Quran

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