Neovascularization of the amniotic membrane as a biological immune barrier

Mahgoub, Mohamed M; Amany, Abdo; Mary, F. Fontana; Edris, Ali Mahmoud Mohammed; Hazem, A; Abdullah, Maha

doi:10.1097/00007890-200308271-00148

Cited by 3 publications

(3 citation statements)

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“…The potential of amniotic membranes to promote angiogenesis and survive without rejection was shown in a previous work, in which allogeneic amniotic membranes were implanted into the peritoneal cavity in a canine model. The authors concluded that their observation should pave the way for the use of amniotic membranes as immunoisolators for pancreatic islets …”

Section: Discussionmentioning

confidence: 99%

Shielding islets with human amniotic epithelial cells enhances islet engraftment and revascularization in a murine diabetes model

Lebreton

Bellofatto

Wassmer

et al. 2020

American Journal of Transplantation

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Hypoxia is a major cause of considerable islet loss during the early posttransplant period. Here, we investigate whether shielding islets with human amniotic epithelial cells (hAECs), which possess anti‐inflammatory and regenerative properties, improves islet engraftment and survival. Shielded islets were generated on agarose microwells by mixing rat islets (RIs) or human islets (HI) and hAECs (100 hAECs/IEQ). Islet secretory function and viability were assessed after culture in hypoxia (1% O2) or normoxia (21% O2) in vitro. In vivo function was evaluated after transplant under the kidney capsule of diabetic immunodeficient mice. Graft morphology and vascularization were evaluated by immunohistochemistry. Both shielded RIs and HIs show higher viability and increased glucose‐stimulated insulin secretion after exposure to hypoxia in vitro compared with control islets. Transplant of shielded islets results in considerably earlier normoglycemia and vascularization, an enhanced glucose tolerance, and a higher β cell mass. Our results show that hAECs have a clear cytoprotective effect against hypoxic damages in vitro. This strategy improves β cell mass engraftment and islet revascularization, leading to an improved capacity of islets to reverse hyperglycemia, and could be rapidly applicable in the clinical situation seeing that the modification to HIs are minor.

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Section: Discussionmentioning

confidence: 99%

Shielding islets with human amniotic epithelial cells enhances islet engraftment and revascularization in a murine diabetes model

Lebreton

Bellofatto

Wassmer

et al. 2020

American Journal of Transplantation

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“…To combat cancer, lately, the use of AM has attracted much attention of researchers because of its unique properties. Scientists have unrevealed various anti-tumorigenic properties such as anti-angiogenic, immunoregulatory, and pro-apoptotic activities [74][75][76][77][78][79][80][81][82]. The cells most importantly amniotic epithelial and mesenchymal cells can play vital [36].…”

Section: Discussionmentioning

confidence: 99%

Human Amniotic Membrane and Its Anti-cancer Mechanism: a Good Hope for Cancer Therapy

Hossain

Siddika

Adnan

et al. 2019

SN Compr. Clin. Med.

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This review focuses on the probable anti-cancer mechanisms of human amniotic membrane (AM) that may be very helpful for ongoing cancer research activities with AM. A thorough search was conducted on PubMed for any published literature on the anti-cancer role of human AM using the key words, e.g., AM, function of AM, angiogenesis prevention, apoptosis induction by AM. No particular exclusion criteria were set. We selected resources from 1960 to 2018 with special focus on articles published during the last 7 years that revealed information regarding AM-derived factors and their specific functions to prevent cancer. Many studies suggest that human AM-derived epithelial stem cells (AM-hAECs) and mesenchymal stem cells (AM-hMSCs) secrete various factors, e.g., thrombospondin (TSP), tissue inhibitor metalloproteinase (TIMP), plasminogen activator inhibitors (PAI), IL-1 receptor antagonist (IL1RN), granulocyte monocyte-colony stimulating factor (GM-CSF), cytokines specially IL-6 and IL-10, various essential markers, and proteins which most predominantly increase the AM's anti-cancer activity. This work gives an overview of the latest findings on AM function and evaluates its potential use in cancer treatment. Though various researches are being performed now on the anti-neoplastic properties of AM, the mechanism of these effects is not clear yet. Therefore, it has a great demand to unveil the mood of action of AM as to exert anti-cancer activity. From the meta-analysis of previous data, this review has pointed out an anti-cancer mechanism of AM that would help to use it as an anti-cancer therapy.

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“…Hence a chorion membrane is an appropriate biomaterial to be used in GTR. 8 The clinical application of chorion membrane for GTR, while fulfilling the current mechanical concept of GTR, amends it with modern concept of biological GTR. [9][10][11][12][13][14] https://doi.org/10.18231/j.jdp.2021.027 2348-8727/© 2021 Innovative Publication, All rights reserved.…”

Section: Introductionmentioning

confidence: 99%

Treatment of localized gingival recession with chorion membrane- A case report

Nair¹,

Janam²,

Manikandan³

2021

JDP

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Aim of root coverage procedure is to restore the tissue margin to the Cemento-enamel junction. Many surgical techniques have been developed throughout the years and Guided tissue regeneration (GTR) based rootcoverage using different allograft membranes has been utilized to treat gingival recession with excellent results.This case report describes a case of gingival recession managed by chorion membrane with coronally advanced flap.

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Neovascularization of the amniotic membrane as a biological immune barrier

Cited by 3 publications

References 0 publications

Shielding islets with human amniotic epithelial cells enhances islet engraftment and revascularization in a murine diabetes model

Shielding islets with human amniotic epithelial cells enhances islet engraftment and revascularization in a murine diabetes model

Human Amniotic Membrane and Its Anti-cancer Mechanism: a Good Hope for Cancer Therapy

Treatment of localized gingival recession with chorion membrane- A case report

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