Neovascular Age-Related Macular Degeneration and Its Association With LOC387715 and Complement Factor H Polymorphism

Mitochondrial DNA haplogroups confer differences in risk for age-related macular degeneration: a case control study

“…Our findings agree with Ross and coworkers who also showed LOC387715 associated with the more advanced clinical-based cases but not the early AMD cases [65]. It is also consistent with two other studies that show that the presence of the T risk allele for the LOC387715 gene is associated with the more severe, wet form of AMD [39,41]. From our case–control study, we found that the association between the T allele for the ARMS2 gene (rs10490924) and AMD is independent of the patient’s mtDNA haplogroup background.…”

Mitochondrial DNA haplogroups confer differences in risk for age-related macular degeneration: a case control study

“…Our findings agree with Ross and coworkers who also showed LOC387715 associated with the more advanced clinical-based cases but not the early AMD cases [65]. It is also consistent with two other studies that show that the presence of the T risk allele for the LOC387715 gene is associated with the more severe, wet form of AMD [39,41]. From our case–control study, we found that the association between the T allele for the ARMS2 gene (rs10490924) and AMD is independent of the patient’s mtDNA haplogroup background.…”

Association Analysis of <b><i>CFH</i></b> and <b><i>ARMS2</i></b> Gene Polymorphisms in a Brazilian Cohort with Age-Related Macular Degeneration

“…These findings are consistent with some previous studies [4,5,6,18]. Nevertheless, there is some controversy on this subject, since some studies suggest that ARMS2 may be more related to exudative AMD [15]. In our work, the heterozygous genotypes of both genes were not related to nonexudative AMD, but this result may be due to the limited number of patients in this sample.…”

Genotype-phenotype correlation of age-related macular degeneration: influence of complement factor H polymorphism

“…In our study, we were not able to confirm any significant difference in the prevalence of either GA or CNV, or early/intermediate AMD, in relation to the Y402H genotype. These results fit well into the inconsistent results reported to date: some investigators have suggested a higher risk for neovascular AMD,22 23 35 36 while others found a trend towards atrophic AMD,20 28 31 33 34 58 or found like us no difference at all 27 30 37 38. It may well be that the influence of Y402H polymorphism on the type of late AMD is minor.…”

Mitochondrial DNA haplogroups confer differences in risk for age-related macular degeneration: a case control study

“…Our findings agree with Ross and coworkers who also showed LOC387715 associated with the more advanced clinical-based cases but not the early AMD cases [65]. It is also consistent with two other studies that show that the presence of the T risk allele for the LOC387715 gene is associated with the more severe, wet form of AMD [39,41]. From our case–control study, we found that the association between the T allele for the ARMS2 gene (rs10490924) and AMD is independent of the patient’s mtDNA haplogroup background.…”

Association Analysis of <b><i>CFH</i></b> and <b><i>ARMS2</i></b> Gene Polymorphisms in a Brazilian Cohort with Age-Related Macular Degeneration

“…These findings are consistent with some previous studies [4,5,6,18]. Nevertheless, there is some controversy on this subject, since some studies suggest that ARMS2 may be more related to exudative AMD [15]. In our work, the heterozygous genotypes of both genes were not related to nonexudative AMD, but this result may be due to the limited number of patients in this sample.…”

Genotype-phenotype correlation of age-related macular degeneration: influence of complement factor H polymorphism

“…In our study, we were not able to confirm any significant difference in the prevalence of either GA or CNV, or early/intermediate AMD, in relation to the Y402H genotype. These results fit well into the inconsistent results reported to date: some investigators have suggested a higher risk for neovascular AMD,22 23 35 36 while others found a trend towards atrophic AMD,20 28 31 33 34 58 or found like us no difference at all 27 30 37 38. It may well be that the influence of Y402H polymorphism on the type of late AMD is minor.…”

Mitochondrial DNA haplogroups confer differences in risk for age-related macular degeneration: a case control study

“…Our findings agree with Ross and coworkers who also showed LOC387715 associated with the more advanced clinical-based cases but not the early AMD cases [65]. It is also consistent with two other studies that show that the presence of the T risk allele for the LOC387715 gene is associated with the more severe, wet form of AMD [39,41]. From our case–control study, we found that the association between the T allele for the ARMS2 gene (rs10490924) and AMD is independent of the patient’s mtDNA haplogroup background.…”

Association Analysis of <b><i>CFH</i></b> and <b><i>ARMS2</i></b> Gene Polymorphisms in a Brazilian Cohort with Age-Related Macular Degeneration

“…These findings are consistent with some previous studies [4,5,6,18]. Nevertheless, there is some controversy on this subject, since some studies suggest that ARMS2 may be more related to exudative AMD [15]. In our work, the heterozygous genotypes of both genes were not related to nonexudative AMD, but this result may be due to the limited number of patients in this sample.…”

Genotype-phenotype correlation of age-related macular degeneration: influence of complement factor H polymorphism

“…In our study, we were not able to confirm any significant difference in the prevalence of either GA or CNV, or early/intermediate AMD, in relation to the Y402H genotype. These results fit well into the inconsistent results reported to date: some investigators have suggested a higher risk for neovascular AMD,22 23 35 36 while others found a trend towards atrophic AMD,20 28 31 33 34 58 or found like us no difference at all 27 30 37 38. It may well be that the influence of Y402H polymorphism on the type of late AMD is minor.…”