2002
DOI: 10.2174/1389200024605082
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Increased amounts of neopterin are produced by human monocytes/macrophages upon stimulation with the cytokine interferon-y. Therefore, measurement of neopterin concentrations in body fluids like serum, cerebrospinal fluid or urine provides information about activation of T helper cell 1 derived cellular immune activation. Increased neopterin production is found in infections by viruses including human immunodeficiency virus (HIV), infections by intracellular living bacteria and parasites, autoimmune diseases, … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

26
546
5
10

Year Published

2007
2007
2023
2023

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 636 publications
(587 citation statements)
references
References 4 publications
26
546
5
10
Order By: Relevance
“…Viral infection is typical morbidity, during which neopterin concentrations in serum increases what was stated on the basis of tests carried out in patients ill from chickenpox, German measles, epidemic parotitis, influenza, viral hepatitis, AIDS (13)(14)(15)(16). In the present study we also found the high levels of neopterin concentration in the acute phase of rotavirus diarrhea and characteristically low concentrations three weeks after discharge from hospital.…”
Section: Discussionsupporting
confidence: 81%
“…Viral infection is typical morbidity, during which neopterin concentrations in serum increases what was stated on the basis of tests carried out in patients ill from chickenpox, German measles, epidemic parotitis, influenza, viral hepatitis, AIDS (13)(14)(15)(16). In the present study we also found the high levels of neopterin concentration in the acute phase of rotavirus diarrhea and characteristically low concentrations three weeks after discharge from hospital.…”
Section: Discussionsupporting
confidence: 81%
“…Neopterin, a 2-amino-4-hydroxy-(1′2′3′-trihydroxypropyl)-pteridine, is produced from guanosine triphosphate (GTP) via GTP cyclohydrolase I by activated monocytes/macrophages [26]. The activity of this enzyme is greatly enhanced by IFN-γ [26].…”
Section: Measurement Of Serum Cytokine Levelsmentioning
confidence: 99%
“…Increased neopterin concentrations are observed in many diseases in which cell immunity is stimulated. In interferon-γ-stimulated macrophages guanosine triphosphate is converted to neopterin (1).…”
Section: Introductionmentioning
confidence: 99%