2004
DOI: 10.1001/archderm.140.9.1156
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Neoplastic Stem Cells in Cutaneous Lymphomas

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Cited by 21 publications
(15 citation statements)
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“…5 Putative lymphocyte precursors in the bone marrow could have low mitotic activity, a characteristic feature of the neoplastic stem cells, which may explain the frequent recurrence of LyP after even successful chemotherapy for lymphoma. 25 The appearance of 2 different clones does not exclude the stem cell hypothesis. The hypothetical stem cell could be at a stage of differentiation before T-cell receptor gene rearrangement, that is, it could be capable of giving rise to T cells with multiple different T-cell receptor gene rearrangements.…”
Section: Commentmentioning
confidence: 99%
“…5 Putative lymphocyte precursors in the bone marrow could have low mitotic activity, a characteristic feature of the neoplastic stem cells, which may explain the frequent recurrence of LyP after even successful chemotherapy for lymphoma. 25 The appearance of 2 different clones does not exclude the stem cell hypothesis. The hypothetical stem cell could be at a stage of differentiation before T-cell receptor gene rearrangement, that is, it could be capable of giving rise to T cells with multiple different T-cell receptor gene rearrangements.…”
Section: Commentmentioning
confidence: 99%
“…5,6 Based on the generally accepted hypothesis that tumors are composed of neoplastic stem cells and their progeny, comparison of normal to neoplastic stem cells may elucidate the fundamental nature of neoplasia. [7][8][9][10][11][12] In human skin, most work has focused on stem cells of the epidermis and adnexal structures. 11,13,14 Epithelial stem cells are also widely studied in other tissues.…”
Section: Introductionmentioning
confidence: 99%
“…The development of CTCL in the patient, as a result of the SCT, may be explained by the lymphoma stem-cell theory, as described by Gniadecki et al 20,21 This theory describes how abnormally formed haematopoietic tissue from lymphoma stem cells undergoes a process of differentiation by progenitor intermediates. When either the lymphoma stem cells or progenitor cells home to the skin, the final tumour is developed.…”
Section: Donor-bmmentioning
confidence: 99%
“…When either the lymphoma stem cells or progenitor cells home to the skin, the final tumour is developed. 20,21 This theory may also illustrate why although local radiation therapy, as in the recipient, or phototherapy may apparently clear skin disease in CTCL, precursor lymphoma cells are unaffected by these localized treatments and disease may recur at a later stage. 20,21 In summary, we have described the second reported case of transmitted CTCL following allogeneic SCT.…”
Section: Donor-bmmentioning
confidence: 99%