Neonatal spontaneous colonic perforation due to cystic fibrosis

Abstract

We report two cases of spontaneous colonic perforation associated with cystic fibrosis (CF) in the neonatal period. Both presented with an acute abdomen soon after birth and required laparotomy and stoma formation. Colonic perforation as an initial presentation of CF is reviewed and management options are discussed.

Neonatal colonic perforation

“…In 12%-15% of patients with cystic fibrosis, meconium ileus is found. Perforation develops frequently in the mid-ileum, and colonic perforation is rarely seen (3,6). However, none of these conditions was present in our case.…”

“…Necrotizing enterocolitis (NEC), Hirschsprung disease (HD), anorectal malformations (ARMs), and mechanical obstructions, like intestinal atresias, small left colon syndrome, meconium plaque syndrome, stercoral perforation, idiopathic perforation, cystic fibrosis, and isolated intestinal perforation, are some of the causes of colonic perforation occurring during the neonatal period (1)(2)(3)(4).…”

Six-year retrospective analysis of colonic perforation in neonates and infants: Single centre experience

“…Furthermore, both the entities have relatively good prognosis compared to NEC of prematurity. [2,[13][14][15] To conclude, HD is not only the most common cause of large bowel obstruction in the young infant, but also the most common cause of perforation. Every neonate and infant should be evaluated for HD for CP, whether history and per-operative findings (identifiable TZ) are suggestive of it or not.…”

“…[1] Colonic perforation (CP) may be caused by various conditions such as necrotising enterocolitis (NEC), Hirschsprung's disease (HD), mechanical obstructions (anorectal malformation [ARM], colonic atresia), meconium plug syndrome, small left colon syndrome, idiopathic perforations, isolated intestinal perforation, stercoral perforations and rarely cystic fibrosis. [1,2] We evaluated the aetiology of CP in neonates and infants, and present our experience in this report.…”

Recurrent Spontaneous Colonic Perforation in a 10- years-old Child

“…The causes of colonic perforation are not clearly established and can be related to many conditions such as infectious diseases, genetic disorders, and vascular conditions. During neonatal period, colonic perforation may be caused by necrotising enterocolitis, Hirschsprung's disease, mechanical obstructions (anorectal malformation, colonic atresia), small left colon syndrome, or rarely, cystic fibrosis [1]. However in older children this pathology has not been extensively studied, and the pathogenesis of this disease has not yet been elucidated.…”