Neonatal sepsis in Iran: A systematic review and meta-analysis on national prevalence and causative pathogens

Rad, Zahra Akbarian; Riahi, Seyed Mohammad; Abdollahi, Ali; Sabbagh, Parisa; Ebrahimpour, Soheil; Javanian, Mostafa; Vasigala, VeneelaKrishnaRekha; Rostami, Ali

doi:10.1371/journal.pone.0227570

Cited by 26 publications

(35 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present research, 182 G − bacterial strains were detected, accounting for 25.74%. The proportion of the positive rate of G − bacteria was lower than that in previous similar literature reports (Pius et al, 2016;Akbarian-Rad et al, 2020). This may be related to the high positive rate of CNS (accounting for 50.77%) in the study.…”

Section: Discussioncontrasting

confidence: 78%

Epidemiology and Drug Resistance of Neonatal Bloodstream Infection Pathogens in East China Children’s Medical Center From 2016 to 2020

Zhang

Tao

et al. 2022

Front. Microbiol.

View full text Add to dashboard Cite

IntroductionTo analyze the pathogen distribution and drug resistance of newborns with bloodstream infection (BSI) to help clinicians choose the appropriate empirical antibiotic therapy for clinical infection control.MethodsA total of 707 neonatal BSI cases were retrospectively analyzed. The bacteria in blood culture-positive samples were cultured, identified, and analyzed for drug sensitivity by routine methods. Statistical software was used to compare and analyze the basic data, pathogenic information, and drug resistance of the main bacteria.ResultsThe 5-year average positive rate of neonatal blood culture was 2.50%. The number of specimens submitted for inspection in 2020 significantly decreased. The top five infectious pathogens with the highest proportion were coagulase-negative Staphylococcus (67.35%), of which Staphylococcus epidermidis had the highest proportion (31.26%), followed by Escherichia coli (12.87%), Klebsiella pneumoniae (9.05%), Streptococcus agalactiae (8.63%), and Staphylococcus aureus (3.25%). Gram-positive (G+) bacteria were dominant, accounting for 69.45%. The main G+ bacteria had a higher rate of resistance to erythromycin and penicillin G. The main Gram-negative (G–) bacteria had a high resistance rate to a variety of antibacterial drugs, especially cephalosporin antibiotics. The overall resistance of K. pneumoniae was higher than that of E. coli. The top two fungi detected were Candida parapsilosis and Candida albicans. C. parapsilosis did not appear to be resistant to antibiotics, while C. albicans was resistant to multiple antibiotics. The type of microbial infection had a statistically significant difference in the positive rate among the age at delivery and wards (p < 0.05). There were significant differences in the detection of fungi among these groups (p < 0.05). The positive rate of G+ bacteria in the term newborns was significantly higher than that in the preterm newborns (p < 0.05). Preterm newborns are more susceptible to pneumonia.ConclusionG+ bacteria are the main pathogens of neonatal BSI. Preterm newborns are more likely to be infected with G– bacteria. E. coli and K. pneumoniae are the most common G– bacteria, and both have a high resistance rate to a variety of antibacterial drugs. According to the distribution characteristics and drug resistance, it is very important to select antibiotics reasonably.

show abstract

Section: Discussioncontrasting

confidence: 78%

Epidemiology and Drug Resistance of Neonatal Bloodstream Infection Pathogens in East China Children’s Medical Center From 2016 to 2020

Zhang

Tao

et al. 2022

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

“…The peptide extracts and synthetic peptides were tested against three representative bacterial species: S. aureus , E. coli , and B. infantis . Depending on geographic location, S. aureus and E. coli are responsible for up to 18% and 23% of cases of neonatal sepsis, respectively [ 42 , 43 , 44 ]; and high levels of fecal E. coli has been associated with necrotizing enterocolitis outbreaks [ 45 ]. B. infantis is the predominant colonizer of a healthy infant microbiome and is associated with reduced inflammation and dysbiosis [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Peptides from the Intestinal Tract of Breast Milk-Fed Infants Have Antimicrobial and Bifidogenic Activity

Beverly

Woonnimani

Scottoline

et al. 2021

IJMS

View full text Add to dashboard Cite

For bioactive milk peptides to be relevant to infant health, they must be released by gastrointestinal proteolysis and resist further proteolysis until they reach their site of activity. The intestinal tract is the likeliest site for most bioactivities, but it is currently unknown whether bioactive milk peptides are present therein. The purpose of the present study was to identify antimicrobial and bifidogenic peptides in the infant intestinal tract. Milk peptides were extracted from infant intestinal samples, and the activities of the bulk peptide extracts were determined by measuring growth of Escherichia coli, Staphylococcus aureus, and Bifidobacterium longum spp. infantis after incubation with serial dilutions. The peptide profiles of active and inactive samples were determined by peptidomics analysis and compared to identify candidate peptides for bioactivity testing. We extracted peptides from 29 intestinal samples collected from 16 infants. Five samples had antimicrobial activity against S. aureus and six samples had bifidogenic activity for B. infantis. We narrowed down a list of 6645 milk peptides to 11 candidate peptides for synthesis, of which 6 fully inhibited E. coli and S. aureus growth at concentrations of 2500 and 3000 µg/mL. This study provides evidence for the potential bioactivity of milk peptides in the infant intestinal tract.

show abstract

“…It is clear that neonatal sepsis is one of the public health problems affecting the survival of children, primarily in countries included in this study [ 48 ]. Neonatal sepsis is frequently reported by prior studies as a predictor of NM [ 2 , 49 , 50 ]. Likewise, perinatal asphyxia is found to have a main predictor of NM.…”

Section: Discussionmentioning

confidence: 99%

Incidence Density Rate of Neonatal Mortality and Predictors in Sub-Saharan Africa: A Systematic Review and Meta-Analysis

Bitew

Alemu

Ayele

et al. 2020

International Journal of Pediatrics

View full text Add to dashboard Cite

Background. Neonatal mortality in Sub-Saharan countries is remarkably high. Though there are inconsistent studies about the incidence density rate of neonatal mortalities (IDR) and predictors in Sub-Saharan Africa, they are inconclusive to policymakers and program planners. In this study, the IDR of neonatal mortalities and predictors was determined. Methods. Electronic databases (Web of Science, PubMed, EMBASE (Elsevier), Scopus, CINAHL (EBSCOhost), World Cat, Google Scholar, and Google) were explored. 20 out of 818 studies were included in this study. The IDRs and predictors of neonatal mortality were computed from studies conducted in survival analysis. Fixed and random effect models were used to compute pooled estimates. Subgroup and sensitivity analyses were performed. Results. Neonates were followed for a total of 1,095,611 neonate-days; 67142 neonate-days for neonates treated in neonatal intensive care units and 1,028,469 neonate-days for community-based studies. The IDRs of neonatal mortalities in neonatal intensive care units and in the community were 24.53 and 1.21 per 1000 person-days, respectively. The IDRs of early and late neonatal mortalities neonatal intensive care units were 22.51 and 5.09 per 1000 neonate-days, respectively. Likewise, the IDRs of early and late neonatal mortalities in the community were 0.85 and 0.31, respectively. Not initiating breastfeeding within one hour, multiple births, rural residence, maternal illness, low Apgar score, being preterm, sepsis, asphyxia, and respiratory distress syndrome were independent predictors of time to neonatal mortality in neonatal intensive care units and male gender, perceived small size, multiple births, and ANC were predictors of neonatal mortality in the community. Conclusion. The incidence density rate of neonatal mortality in Sub-Saharan Africa is significantly high. Multiple factors (neonatal and maternal) were found to be independent predictors. Strategies must be designed to address these predictors, and prospective studies could reveal other possible factors of neonatal mortalities.

show abstract

Neonatal sepsis in Iran: A systematic review and meta-analysis on national prevalence and causative pathogens

Cited by 26 publications

References 33 publications

Epidemiology and Drug Resistance of Neonatal Bloodstream Infection Pathogens in East China Children’s Medical Center From 2016 to 2020

Epidemiology and Drug Resistance of Neonatal Bloodstream Infection Pathogens in East China Children’s Medical Center From 2016 to 2020

Peptides from the Intestinal Tract of Breast Milk-Fed Infants Have Antimicrobial and Bifidogenic Activity

Incidence Density Rate of Neonatal Mortality and Predictors in Sub-Saharan Africa: A Systematic Review and Meta-Analysis

Contact Info

Product

Resources

About