Neonatal secretion of secretin.

Rogers, Ian Munro; Davidson, D C; Lawrence, Joyce; Buchanan, K. D.

doi:10.1136/adc.50.2.120

Cited by 14 publications

(6 citation statements)

References 11 publications

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“…These data confirm the findings of Rog ers et al [7] regarding similar elevations in serum secretin levels in human neonates. The response to duodenal acidification was a striking elevation of mean secretin levels to 2,090 pg/ml.…”

Section: Discussionsupporting

confidence: 92%

“…In addition to elevated plasma secretin levels in the neonate [7], several studies re port increased gastrin levels in fasting human infants during the first week of life [1][2][3]. We have reported similar hypergastrinemia in the newborn swine [4], In adult animals, pharmacological doses of secretin inhibit gas trin release and gastrin-stimulated acid secre tion [16,17], Preliminary work indicates that these inhibitory effects may also be seen at physiological secretin concentrations [18].…”

Section: Discussionmentioning

confidence: 69%

“…Subsequent studies confirmed the presence of hypergastrinemia in the fasting state in the newborn animal, with an absence of postprandial ele vations following protein stimulus in marked contradistinction to the response seen in the adult subject [4], Despite this, there is a dearth of knowledge regarding the regulation of the gastrointestinal hormone secretin in the newborn animal. In 1975, Rogers et al [7] reported elevated serum secretin levels in 4-day-old human neonates when compared to the levels in the maternal circulation. More recently, Lucas et al [6] reported serum secretin concentrations in a large group of term and pre-term infants.…”

Section: Discussionmentioning

confidence: 99%

“…To ex plore these hypotheses further, an animal model is obviously necessary as ethical con siderations make it a difficult project to un dertake in the human neonate. As the pig is an omnivore and its gastrointestinal physiol ogy is closely related to that of humans, this animal has served successfully as a model to gain insight into the function of the gastroin testinal tract of the human subject [7,8],…”

Section: Discussionmentioning

confidence: 99%

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Secretin Levels in Plasma and Tissue of the Neonatal Swine

Moazam¹,

Rodgers²,

Kolts³

1982

Neonatology

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The mean fasting serum secretin level determined in newborn swine was found to be 298.0 ± (SEM) 5 pg/ml, significantly higher than that in the adult animal. Intraduodenal infusion of 0.1 N HCI produced dramatic elevation of the mean serum secretin level to 2,090 ± 340 pg/ml. The tissue secretin concentration of duodenal mucosa as well as the molecular species of tissue secretin were found to be identical to that of the adult swine. The mean disappearance half-life of exogenously administered secretin in the newborn swine was significantly prolonged over adult values, to 3.6 min. These data suggest that delayed secretin degradation can be implicated as a factor in the etiology of the hypersecretinemia in the newborn swine.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Secretin Levels in Plasma and Tissue of the Neonatal Swine

Moazam¹,

Rodgers²,

Kolts³

1982

Neonatology

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“…Recent work in mature neonates has shown that the plasma levels of gastrin, secretin, and enteroglucagon are higher on the fourth day of life than on the first (Rogers et al, 1974(Rogers et al, , 1975, suggesting that the gastrointestinal hormones themselves have an immaturity of response which takes some time to develop fully. However, we found a rise in plasma gastrin and enteroglucagon, although there was no change in plasma GIP.…”

Section: Discussionmentioning

confidence: 99%

Endocrine and metabolic response in the human newborn to first feed of breast milk.

Aynsley-Green¹,

Bloom²,

Williamson³

1977

Archives of Disease in Childhood

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SUMMARY The hormonal and metabolic response to the first feed of breast milk was studied in 12 infants at 4-6 hours of age. After the feed there was an increase in blood glucose concentration but no changes in the concentrations of lactate, pyruvate, alanine, or ketone bodies. The feed was followed by an increase in the concentrations of plasma insulin, growth hormone, gastrin, and enteroglucagon, but no change in levels of plasma glucagon or gastric inhibitory peptide. Several hormone systems are functionally active at birth and are stimulated by the first feed of milk.At birth the continuous supply of nutrients which the fetus received across the placenta is interrupted and the neonate has to adapt to a new environment of intermittent feeding and fasting. There is evidence that changes in plasma hormone concentrations after birth are responsible for some of the changes in hepatic enzyme activity which occur during the period of metabolic adaptation (Shelley et al., 1975). Animal studies have shown that postnatal feeding modulates the development of glucose-stimulated insulin secretion (Gentz et al., 1971;Asplund, 1972). However, the effect of feeding on gastrointestinal and pancreatic insular hormone secretion and their relationship to circulating blood metabolite concentrations have not been studied in the human newborn.We report measurements of the blood levels of several hormones and metabolites before and after the first feed of expressed breast milk in a group of infants suffering from moderately severe respiratory distress. Patients and methodsTwelve infants were studied with the approval of the Ethical Committee. All had been admitted to the special care baby unit, and all had indwelling umbilical arterial catheters for clinical monitoring purposes. They were nursed in infant incubators at an environmental temperature appropriate for their weight and gestation (Hey and Katz, 1970). None had a rectal temperature lower than 360C at the time Received 27 July 1976 of the study. The mean birthweight was 2945 g (range 2110-3940 g) and mean gestational age 37 8 weeks (range 37-39 weeks). 9 infants were suffering from moderately severe respiratory distress requiring enriched inspired oxygen concentrations. Of the other 3, one was a breech delivery with severe birth asphyxia and 2 had lesser degrees of birth asphyxia requiring transient endotracheal intubation, oxygen, and alkali therapy. None had an arterial pH <7 25, and the inspired oxygen concentration was adjusted to maintain the Pao2 in the range 60-90 torr. No change in inspired oxygen concentration was required during the study period and the clinical condition of the infants did not change.Feeding procedure. The first feed was given between 4 and 6 hours of age. Nasogastric tubes were inserted and the stomach contents aspirated 30 minutes before the feed. When the contents were copious, tenacious, or heavily stained with meconium 5-10 ml of 0 9% saline at 37°C were used to irrigate the stomach, the contents being reaspirated. The infants were then gi...

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Digestion and Absorption

Koldovský

1978

Perinatal Physiology

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Neonatal secretion of secretin.

Cited by 14 publications

References 11 publications

Secretin Levels in Plasma and Tissue of the Neonatal Swine

Secretin Levels in Plasma and Tissue of the Neonatal Swine

Endocrine and metabolic response in the human newborn to first feed of breast milk.

Digestion and Absorption

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