2018
DOI: 10.3748/wjg.v24.i45.5109
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Abstract: AIMTo establish a rotavirus (RV)-induced diarrhea model using RV SA11 in neonatal rhesus monkeys for the study of the pathogenic and immune mechanisms of RV infection and evaluation of candidate vaccines.METHODSNeonatal rhesus monkeys with an average age of 15-20 d and an average weight of 500 g ± 150 g received intragastric administration of varying doses of SA11 RV ( 107 PFUs/mL, 106 PFUs/mL, or 105 PFUs/mL, 10 mL/animal) to determine whether the SA11 strain can effectively infect these animals by observing … Show more

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Cited by 9 publications
(6 citation statements)
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“…In our previous study, we have successfully established a RV infection diarrhea model using the SA11 strain RV in neonatal rhesus monkeys . In this study, we also demonstrated that rhesus infants are susceptible to infection and disease with the RV SA11 G3P[2] strain and RV ZTR‐68 wild‐type strain G1P[8].…”
Section: Introductionmentioning
confidence: 74%
See 1 more Smart Citation
“…In our previous study, we have successfully established a RV infection diarrhea model using the SA11 strain RV in neonatal rhesus monkeys . In this study, we also demonstrated that rhesus infants are susceptible to infection and disease with the RV SA11 G3P[2] strain and RV ZTR‐68 wild‐type strain G1P[8].…”
Section: Introductionmentioning
confidence: 74%
“…And the immune mechanisms involved in clearance of and immunity to RV infection need to be uncovered. In our previous study, we have successfully established a RV infection diarrhea model using SA11 strain RV in neonatal rhesus monkeys . In this study, we investigated the gene expression changes in PBMCs and cytokine response of serum from neonatal rhesus monkey models, which were infected with the monkey SA11 strain (G3[P2]) and the human ZTR‐68 strain (G1[P8]).…”
Section: Discussionmentioning
confidence: 99%
“…Rotavirus (RV) belongs to the reovirus subfamily and is the most important causative agents of viral diarrhea in infants and young children, as well as many young animals worldwide (1). It is also the major causative agent of acute diarrhea in children under 5 years of age, which may lead to mortality in severe cases (2).…”
Section: Introductionmentioning
confidence: 99%
“…RV represent the most important etiologic agents of viral gastroenteritis in infants and young children, as well as many young animals world wide. 7 It is also the major viral agent of acute gastroenteritis in children<5 years of age, which may lead to death in severe cases. 8 The primary rout of RV transmission is the fecal-oral route via person-to-person contact or swallowing of fecally contaminated water and food, with waterborne being one of the most important exposure pathways.…”
Section: Introductionmentioning
confidence: 99%