Neonatal Resuscitation: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations

Transcriptome profiling of the newborn mouse lung after hypoxia and reoxygenation: hyperoxic reoxygenation affects mTOR signaling pathway, DNA repair, and JNK-pathway regulation

“…This can have long-term consequences contributing to the development of bronchopulmonary dysplasia (9). Current revised neonatal resuscitation guidelines recommend starting resuscitation with air for the term and near-term infant, but there is still no consensus on which FiO 2 to administer to the preterm (10). Recent data (11) indicate lower oxidative stress and long-term lung injury after resuscitation of preterm born babies with 30 vs. 90% oxygen.…”

Resuscitation with 100% oxygen increases injury and counteracts the neuroprotective effect of therapeutic hypothermia in the neonatal rat

“…The new and important knowledge added by this study is the effect of the combination of these two important interventions recommended by the International Liaison Committee on Resuscitation guidelines (10). A recent study in a short-termsurvival newborn pig model (16) suggested that the protective effect of HT was stronger after hyperoxia.…”

“…In the UK, the National Institute for Health and Clinical Excellence has declared that HT should be used as standard of care after perinatal asphyxia (9). HT after perinatal asphyxia is also recommended by the recent 2010 International Resuscitation Guidelines (International Liaison Committee on Resuscitation) (10). HT suppresses many of the pathways that lead to delayed energy failure and cell death after hypoxia (11,12), including generation of reactive oxygen species (13), excitotoxicity (14), and the inflammatory response (15).…”

“…Supplemental oxygen was previously recommended for resuscitation of the asphyxiated newborn infant, but after the changes in the 2010 International Liaison Committee on Resuscitation guidelines, it is now recommended that resuscitation of the term infant is best started with air, rather than pure oxygen (10). Evidence from animal studies shows that supplemental oxygen during resuscitation causes significant hyperoxia in the newborn brain (16,17), with increased generation of reactive oxygen species (18), oxidative stress (19), inflammation (20), and cerebral injury (19,21,22).…”

The transition to extra‐uterine life by extremely preterm infants – handle with care

“…Resuscitation protocols, such as the guidelines by the International Liaison Committee on Resuscitation (ILCOR) (1), have contributed to improving and standardising management. A number of advancements have made it possible to resuscitate premature infants born at progressively earlier gestational ages.…”