Neonatal Respiratory Disease

Maamoun, Waleed; Fort, Amber E.; Cummings, James J.

doi:10.1016/b978-0-323-07307-3.10046-1

Cited by 4 publications

(2 citation statements)

References 214 publications

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“…This absorption of extravascular fluid began in rabbits 30 to 60 min after birth and then decreased continuously. Absorption of interstitial fluid is also believed to occur in neonatal foals and human babies and appears be complete by about 6 h after birth [ 50 , 51 ]. This time period corresponds with the most pronounced decrease in DSS seen in the present study.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Postnatal Pulmonary Adaption in Bovine Neonates Using Electric Impedance Tomography (EIT)

Bleul

Wey

Meira

et al. 2021

Animals

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Several aspects of postnatal pulmonary adaption in the bovine neonate remain unclear, particularly the dynamics and regional ventilation of the lungs. We used electric impedance tomography (EIT) to measure changes in ventilation in the first 3 weeks of life in 20 non-sedated neonatal calves born without difficulty in sternal recumbency. Arterial blood gas variables were determined in the first 24 h after birth. Immediately after birth, dorsal parts of the lungs had 4.53% ± 2.82% nondependent silent spaces (NSS), and ventral parts had 5.23% ± 2.66% dependent silent spaces (DSS). The latter increased in the first hour, presumably because of gravity-driven ventral movement of residual amniotic fluid. The remaining lung regions had good ventilation immediately after birth, and the percentage of lung regions with high ventilation increased significantly during the study period. The centre of ventilation was always dorsal to and on the right of the theoretical centre of ventilation. The right lung was responsible for a significantly larger proportion of ventilation (63.84% ± 12.74%, p < 0.00001) compared with the left lung. In the right lung, the centrodorsal lung area was the most ventilated, whereas, in the left lung, it was the centroventral area. Tidal impedance changes, serving as a surrogate for tidal volume, increased in the first 3 weeks of life (p < 0.00001). This study shows the dynamic changes in lung ventilation in the bovine neonate according to EIT measurements. The findings form a basis for the recognition of structural and functional lung disorders in neonatal calves.

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Section: Discussionmentioning

confidence: 99%

Assessment of Postnatal Pulmonary Adaption in Bovine Neonates Using Electric Impedance Tomography (EIT)

Bleul

Wey

Meira

et al. 2021

Animals

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“…Meconium amniotic uid (MAF) occurs when there is a passage of the fetal colonic contents into the amniotic cavity (2). Although water makes up 85-95% of meconium, the remaining 5-15% comprises gastric secretions, bile salts, mucus, vernix, lanugo, blood, pancreatic enzymes, free fatty acids, and squamous cells (3). Intrauterine meconium passage in near-term or term fetuses has been linked to fetomaternal stress factors and/or infection, whereas post-term meconium passage has been linked to gastrointestinal maturation (1).…”

Section: Introductionmentioning

confidence: 99%

The incidence and risk factors of meconium amniotic fluid in singleton pregnancies: An experience of a tertiary hospital in Iran

Shekari

Jahromi

Ranjbar

et al. 2022

Preprint

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Background: Several common maternal or neonatal risk factors have been linked to MAF development; however, the results were contradictory, depending on the study. This study aimed to assess the prevalence and risk factors of MAF in singleton pregnancies.Methods: We retrospectively assessed singleton pregnant mothers who gave birth at Khaleej-e-Fars Hospital (a tertiary hospital) in Bandar Abbas, Iran, between January 1st, 2020, and January 1st, 2022. Mothers were divided into two groups: 1) those diagnosed with meconium amniotic fluid and 2) those diagnosed with clear amniotic fluid. Mothers with bloody amniotic fluid were excluded. Demographic factors (age, educational level, residency place, medical insurance, access to prenatal care facilities, smoking status), obstetrical factors (gestational age, parity, newborn sex, oligohydramnios, preeclampsia, gestational diabetes mellitus (GDM), abnormal placentation, placenta abruption, chorioamnionitis, intrauterine growth restriction (IUGR), and intrauterine fetal death (IUFD)) and maternal comorbidities (overt diabetes mellitus, chronic hypertension, cardiovascular disease, thyroid dysfunction, drug addiction, hepatitis, anemia, infertility, and COVID-19 at the time of admission) were extracted from electronic data of each mother. The Chi-square test was used to compare differences between the groups for categorical variables. Logistic regression models were used to assess meconium amniotic fluid risk factors.Results: Of 8888 singleton deliveries during the study period, 1085 (12.2%) were MAF. MAF was more common in adolescents, mothers with post-term pregnancy, and primiparous mothers, and it was less common in mothers with GDM and overt diabetes. The odds of having MAF in adolescents were three times more than mothers of 20-34 years old (aOR: 3.07, 95%CI: 1.87–4.98). Likewise, the odds of the presence of MAF in mothers with post-date pregnancy (40+1-41 weeks) were (aOR: 5.12, 95%CI: 2.76–8.94), and mothers with post-term pregnancy (more than 41 weeks) were (aOR: 7.09, 95%CI: 3.92–9.80). Primiparous women were also more likely than multiparous mothers to have MAF (aOR: 3.41, 95%CI: 2.11–4.99).Conclusions: Adolescents, primiparous mothers, and mothers with post-term pregnancies had a higher risk of MAF. Maternal comorbidities resulting in early termination of pregnancy can reduce the incidence of MAF.

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