Neonatal pemphigus

Tatian, Artiene; Sun, Helen; Singh, Eshana; Saikal, Samra L; Sebaratnam, Deshan F

doi:10.1111/jpc.14917

Cited by 4 publications

(4 citation statements)

References 6 publications

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“…Reasons for premature delivery included premature rupture ( n = 3), 15–17 placenta previa ( n = 1), 18 and placental insufficiency ( n = 1) 12 . One (2.7%) neonate was born after 43 weeks of gestational age, 19 and one (2.7%) died of miscarriage 9 . Ten (27.0%) neonates were diagnosed with neonatal pemphigus vulgaris, and two (5.4%) neonates were suspected of having neonatal pemphigus but did not receive a clear diagnosis.…”

Section: Resultsmentioning

confidence: 99%

“…TA B L E 3 Data on pregnant patients with pemphigus vulgaris onset during the postpartum period. 3 premature rupture, 15,16 1 placenta previa, 18 1 placental insufficiency, 17 1 prolonged pregnancy, 19 1 miscarriage 9 3 still birth 7 , 1 premature rupture 21 , 1 simple premature delivery 22 1 fetal distress 4 2 reported "small for date" 51 This study presents two cases of pemphigus vulgaris in women who achieved remission before but experienced a relapse during pregnancy. Although the impact on the fetus is limited, these cases offer insights into the potential relapse in patients who attained remission before pregnancy.…”

Section: Referencementioning

confidence: 98%

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Pregnancy in pemphigus vulgaris: A systematic review

Lan,

Zhang,

Jin

2024

American J Rep Immunol

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ProblemPemphigus vulgaris may worsen during pregnancy, leading to both maternal and fetal complications. The relationship between pemphigus vulgaris and pregnancy remains unclear, and the outcomes and treatments of pemphigus vulgaris during pregnancy have not been extensively discussed.Method of StudyThis article systematically reviews the literature, focusing on the relationship between pemphigus vulgaris and pregnancy. We conducted comprehensive searches in PubMed, Embase, Cochrane Library, and Web of Science databases, identifying 42 studies reporting the disease course, pregnancy outcomes, and management of both pregnancy and pemphigus vulgaris.ResultsA total of 57 cases were included in the analysis, categorized into three distinct forms: pemphigus vulgaris onset before pregnancy (n = 33), onset during pregnancy (n = 20), and onset during the postpartum period (n = 4). Fifty four cases reported treatment strategies, among them, 44 cases (81.5%) initially received systemic corticosteroid therapy during pregnancy. Out of these cases, 7 (15.9%) did not achieve successful remission and required alternative treatment approaches. In terms of pregnancy outcomes, 23 out of 62 neonates (37.1%) exhibited skin lesions or tested positive for anti‐dsg IgG in their serum, while 16 neonates (25.8%) experienced other complications.ConclusionsThese findings highlight the importance of effectively managing pemphigus vulgaris during pregnancy to ensure optimal outcomes.

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Section: Resultsmentioning

confidence: 99%

Section: Referencementioning

confidence: 98%

Pregnancy in pemphigus vulgaris: A systematic review

Lan,

Zhang,

Jin

2024

American J Rep Immunol

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“…However, long‐term follow‐up is required in these patients to detect relapses. No specific treatment is necessary for neonatal PV, as the condition is self‐limiting in 2 to 3 weeks 9,13 . Hence, local wound care with topical emollients is sufficient.…”

Section: Discussionmentioning

confidence: 99%

“…No specific treatment is necessary for neonatal PV, as the condition is self‐limiting in 2 to 3 weeks. 9 , 13 Hence, local wound care with topical emollients is sufficient. Similarly, we managed the neonate with local wound care and topical mupirocin ointment.…”

Section: Discussionmentioning

confidence: 99%

Pemphigus vulgaris in a neonate born to a mother with pemphigus vulgaris: A case report

Anand,

Awake,

Bhosale

et al. 2023

Clinical Case Reports

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Key Clinical MessageActive pemphigus vulgaris in the mother can lead to neonatal pemphigus vulgaris, which is usually self‐limiting. Systemic corticosteroids are the mainstay of managing PV during pregnancy and until the child is breastfed.AbstractPemphigus vulgaris (PV) is a potentially life‐threatening autoimmune disease characterized by bullae and erosions over the skin and mucous membrane. PV is rarely reported in pregnant women and neonates. We reported the case of a 28‐year‐old Gravida 2 Parity 2 Living 1 who developed painful blisters and erosions in the oral cavity during third trimester of pregnancy. However, the diagnosis was delayed due to late presentation. The patient presented to our hospital at 37 weeks gestation with bullae and erosions distributed all over the body. Based on clinical evaluation and histopathology reports, she was diagnosed with PV. She delivered a child via cesarean section. The child also had similar lesions and was diagnosed with neonatal PV. Maternal PV was managed with prednisolone followed by azathioprine, leading to complete remission. No active intervention was required for neonatal PV as the condition was self‐limiting.

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Dermatoses of the Neonate

Clayton,

Sharif

2024

Rook's Textbook of Dermatology

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This chapter provides an overview of neonatal skin function and intrauterine skin development. The impact on the skin of gestational age at birth is discussed along with cutaneous complications arising from prematurity and neonatal medical procedures. Skin care practices and considerations for neonates are summarised and physiological appearances and changes are described. On overview of disordered skin in neonates is provided, including pustular eruptions, atrophic skin lesions, disorders of neonatal fat, colloidion baby, blueberry muffin baby, purpura fulminans and common neonatal dermatosis. The clinical manifestions in a neonate of transplacental transfer of maternal autoantibodies is evaluated, including in conditions such as pemphigus vulgaris, pemphigus foliaceus, herpes gestationis, lupus erythematosus and maternal malignancy. Finally, on overview of infective skin pathologies and clinical manifestations in neonates is provided including viral, bacterial and fungal pathogens.

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Neonatal pemphigus

Cited by 4 publications

References 6 publications

Pregnancy in pemphigus vulgaris: A systematic review

Pregnancy in pemphigus vulgaris: A systematic review

Pemphigus vulgaris in a neonate born to a mother with pemphigus vulgaris: A case report

Dermatoses of the Neonate

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