Neonatal pemphigus foliaceus

Diagnosis and Clinical Features of Pemphigus Foliaceus

“…Non-endemic PF may occur in the neonate via transplacental transit of pathogenic IgG anti-dsg-1 autoantibodies from a mother with active disease (32,33,34). These cases are uncommon and most neonates born of mothers with PF will not develop active disease (35).…”

A rare cause of unilateral facial rash

“…1 Clinically, this manifests as fragile blisters and bullae that are susceptible to rupture, leaving behind erosions. 2 Histopathological examination of PF demonstrates subcorneal acantholysis and blisters with dyskeratotic granular cells. 1 DIF is essential for diagnosis, and typically shows intercellular deposition of IgG and less often C3, which is accentuated in the superficial epidermis.…”

Bullous diseases: Kids are not just little people

“…89 It has been suggested that a higher maternal antibody titer may need to be surpassed before neonatal involvement occurs 90 but too few cases have been reported for conclusions to be drawn.…”

“…are special considerations in women of childbearing potential with autoimmune bullous diseases?Transplacental antibody transfer or vertical transmission of pathogenic antibodies has been described in several autoimmune diseases; one well described is neonatal lupus. Pemphigus vulgaris 82 (termed neonatal pemphigus or pemphigus neonatorum), EBA, 83 BP, 84,85 pemphigus vegetans86 and pemphigus foliaceus87,88,89,90 have been reported to be transmitted in this fashion.…”