Neonatal mesenchymal hamartoma of liver: An unusual presentation

Abstract

Mesenchymal hamartoma of the liver is the second most common benign liver tumor in children. Typically, it presents as a large benign cystic, solid or mixed liver mass in a child younger than 3 years and amenable to complete resection. We report a neonate with Mesenchymal hamartoma of the liver presenting as giant intra abdominal cyst and its rare association with malrotation of bowel.

Giant solid mesenchymal hamartoma of the liver in a neonate: case report

“…Mesenchymal hamartoma of the liver presents most frequently as a multiseptated cystic or mixed solid and cystic tumor; however, it can rarely occur as a solid tumor [3]. Twenty percent of these tumors can be diagnosed during the neonatal period [5]. In this study, the patient was a 3-week-old newborn with a giant solid hamartoma.…”

“…In many cases, these lesions present as giant tumors filling almost the entire abdominal cavity with a diameter of up to 20-30 cm [4]. Large mesenchymal hamartomas usually present with abdominal distension, vomiting, poor weight gain, respiratory distress, cardiac failure, thrombocytopenia, intralesional bleeding, ascites secondary to tumor rupture, obstructive jaundice, and hepatomegaly [5]. Twenty percent of these lesions are diagnosed during the neonatal period as they attain large sizes secondary to their postnatal growth spurt from the rapid accumulation of fluid within them [5].…”

“…Large mesenchymal hamartomas usually present with abdominal distension, vomiting, poor weight gain, respiratory distress, cardiac failure, thrombocytopenia, intralesional bleeding, ascites secondary to tumor rupture, obstructive jaundice, and hepatomegaly [5]. Twenty percent of these lesions are diagnosed during the neonatal period as they attain large sizes secondary to their postnatal growth spurt from the rapid accumulation of fluid within them [5]. Several associated anomalies have been reported including malrotation, Beckwith-Wiedemann syndrome, biliary atresia, and congenital heart diseases [1,5].…”

“…Twenty percent of these lesions are diagnosed during the neonatal period as they attain large sizes secondary to their postnatal growth spurt from the rapid accumulation of fluid within them [5]. Several associated anomalies have been reported including malrotation, Beckwith-Wiedemann syndrome, biliary atresia, and congenital heart diseases [1,5]. Radical surgical excision, whenever possible, is the gold standard for treating these lesions to avoid the problems of local recurrence and possible long-term malignant transformation [2].…”

Mesenchymal Hamartoma of Liver in a Neonate

“…This tumor typically presents as a large benign cystic mass, solid or mix in children less than three years and can be treated with complete removal [2]. Prenatally, it may grow quickly to an abnormal size that may lead to death or hydrops [3].…”