Neonatal Meningitis and Bilateral Cerebellar Abscesses due to &lt;i&gt;Citrobacter freundi&lt;/i&gt;&lt;i&gt;i&lt;/i&gt;

Joaquin, Andrew J.; Khan, Sadid F; Russell, Neville; Fayez, N. Al

doi:10.1159/000120561

Cited by 32 publications

(19 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…especially C. freundii , is recognized as an emerging opportunistic pathogen and is known to cause a variety of infections (UTIs, wound infections, gastrointestinal infections, septicemia, meningitis), especially in immunocompromised patients and in hospital settings (Joaquin et al, 1991; Brenner et al, 1993; Gupta et al, 2003; Samonis et al, 2009; Ranjan and Ranjan, 2013; Leski et al, 2016a). This emergence has coincided with the finding that C. freundii is often resistant to multiple classes of antibiotics, suggesting that both clinical and environmental strains may be a reservoir of antimicrobial resistance determinants (Pepperell et al, 2002; Nada et al, 2004; Yim et al, 2013; Feng et al, 2015; Leski et al, 2016a; Sheppard et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Resistance and Cytotoxicity of Citrobacter spp. in Maanshan Anhui Province, China

et al. 2017

View full text Add to dashboard Cite

Objectives: Citrobacter spp. especially Citrobacter freundii, is frequently causing nosocomial infections, and increasingly becoming multi-drug resistant (MDR). In this study, we aimed to determine the genetic diversity and relationships of Citrobacter spp. from diarrheal patients and food sources, their antimicrobial resistance profiles and in vitro virulence properties.Methods: Sixty two Citrobacter isolates, including 13 C. freundii, 41 C. youngae and eight C. braakii isolates, were obtained from human diarrheal patients and food sources. Multilocus Sequence Typing (MLST) of seven housekeeping genes and antimicrobial susceptibility testing using the broth microdilution method according to CLSI recommendations were carried out. Adhesion and cytotoxicity to HEp-2 cells were performed. PCR and sequencing were used to identify blaCTX−M, blaSHV, blaTEM and qnr genes.Results: The 62 isolates were divided into 53 sequence types (STs) with all STs being novel, displaying high genetic diversity. ST39 was a predominant ST shared by 5 C. youngae strains isolated from four foods and a diarrheal patient. All isolates were resistant to cefoxitin, and sensitive to imipenem, meropenem and amikacin. The majority of Citrobacter isolates (61.3%) were MDR of three or more antibiotics out of the 22 antibiotics tested. Two C. freundii isolates each carried the blaTEM−1 gene and a variant of qnrB77. Three Citrobacter isolates each carried qnrS1 and aac(6')-Ib-cr genes. Seven isolates that showed strong cytotoxicity to HEp-2 cells were MDR.Conclusions: Citrobacter spp. from human and food sources are diverse with variation in virulence properties and antibiotic resistance profiles. Food may be an important source of Citrobacter species in transmission to humans. C. freundii and C. youngae are potential foodborne pathogens.

show abstract

Section: Discussionmentioning

confidence: 99%

Antimicrobial Resistance and Cytotoxicity of Citrobacter spp. in Maanshan Anhui Province, China

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Se sabe que estos microorganismos pueden producir infecciones importantes en seres humanos y otros animales, especialmente en hospederos inmunocomprometidos (Flaherty, García-Houchins, Chudy, Arnow, 1993). También han sido asociados a meningitis neonatal y absceso cerebral (Joaquín, Khna, Russel, Al Fayez. 1991).…”

Section: Resultados Y Discusiónunclassified

Sensibilidad a los antibióticos en bacterias Gram negativas de bulbos de cebolla en Tierra Blanca de Cartago

Quesada¹,

Chin²,

Aguilar³

et al. 2018

View full text Add to dashboard Cite

El objetivo de este estudio fue identificar géneros bacterianos en bulbos de cebolla sanos y bulbos que presentaban síntomas, de la zona de Tierra Blanca de Cartago y determinar la susceptibilidad a los antibióticos gentamicina y tetraciclina, dos de los antibióticos más usados en la agricultura en Costa Rica. El cultivo de la cebolla se practica en diferentes regiones del país, principalmente en la zona de Cartago. Este cultivo puede ser atacado por una gran variedad de plagas y enfermedades que pueden disminuir el crecimiento y la producción, causar daños y desfigurar los bulbos impidiendo su comercialización. Las bacterias que atacan los cultivos causan grandes pérdidas económicas, por eso se han buscado diversos métodos para controlarlas, entre ellos, el uso de antibióticos como tetraciclina y gentamicina. La selección y diseminación en la naturaleza de cepas resistentes a los antibióticos es una práctica que se debe controlar, con el fin de mantener un balance ecológico que favorezca el predominio de bacterias susceptibles y asegurar el tratamiento efectivo de las enfermedades infecciosas humanas.

show abstract

“…It should be noted that bacteria from genera Citrobacter do not pose a risk for healthy people and are frequently encountered in the environments. They are also placed in the opportunistic species group, causing neonatal meningitis and abscesses in men (25).…”

Section: So Far There Is No Data About Reporting the Occurrence Ofmentioning

confidence: 99%

Microorganisms in Vacuum Stored Flower Bee Pollen

Dinkov

2016

J Bacteriol Virol

View full text Add to dashboard Cite

Contamination with sanitary microorganisms from Enterobacteriaceae, Pseudomonadaceae, Staphylococcaceae, Micrococcaceae and Bacillaceae families in flower bee pollen from Bulgaria after one-year vacuum-packed cold storage has been found. Dried flower bee pollens intended for human consumption were with high incidence rate of contamination with Pantoea sp. (P. agglomerans and P. agglomerans bgp6) (100%), Citrobacter freundii (47%), Proteus mirabilis (31.6%), Serratia odorifera (15.8%) and Proteus vulgaris (5.3%). Bee pollens were also positive for the culture of microorganisms from Staphylococcaceae, Micrococcaceae and Bacillaceae families: Staphylococcus hominis subsp hominis, Staphylococcus epidermidis, Arthrobacter globiformis, Bacillus pumilis, Bacillus subtilis and Bacillus amyloliquefaciens. It was concluded that, if consumed directly, the vacuum-packed cold stored dried bee pollen, harvested according hygienic requirements from bee hives in industrial pollution-free areas without intensive crop production, is not problem for healthy human.

show abstract

Neonatal Meningitis and Bilateral Cerebellar Abscesses due to <i>Citrobacter freundi</i><i>i</i>

Abstract: We report bilateral cerebellar abscesses in a neonate with Citrobacter freundii meningitis. The mortality and morbidity of Citrobacter abscess is high. Rapidly developing drug resistance may play a role as illustrated by our case.

Cited by 32 publications

References 4 publications

Antimicrobial Resistance and Cytotoxicity of Citrobacter spp. in Maanshan Anhui Province, China

Antimicrobial Resistance and Cytotoxicity of Citrobacter spp. in Maanshan Anhui Province, China

Sensibilidad a los antibióticos en bacterias Gram negativas de bulbos de cebolla en Tierra Blanca de Cartago

Microorganisms in Vacuum Stored Flower Bee Pollen

Contact Info

Product

Resources

About