Neonatal Malassezia furfur pustulosis

Is Common Neonatal Cephalic Pustulosis (Neonatal Acne) Triggered by Malassezia sympodialis?

“…Furthermore, papulopustular facial lesions in neonates are difficult to interpret clinically; some may correspond to milia and sebaceous gland hyperplasia. As in our previous study, 6 all infants with significant lesions were cured after the application of topical 2% ketoconazole cream twice per day for 1 week. The anti-inflammatory effect of ketoconazole may have had a nonspecific effect similar to that reported for infantile seborrheic dermatitis.…”

Acne neonatorum: a study of 22 cases

“…Recently, P. ovale has been identified in facial pustulosis of neonates. 12 Smears for P. ovale failed to reveal the yeast in six of our patients.…”

Epidemiologic Study ofMalasseziaYeasts in Patients withMalasseziaFolliculitis by 26S rDNA PCR-RFLP Analysis

“…M. sympodialis was found on mycological examination of the folliculitis lesions of renal cell carcinoma patients who underwent treatment with erlotinib, an anticancer agent 33 , and this further increases the possibility of this strain being pathogenic. However, considering that there have been reports, such as those by Crespo and Delgado 6 and Rhie et al 34 , that the main causative agents of Malassezia folliculitis are normal flora of the skin other than M. sympodialis, and that other strains such as M. furfur, had been isolated from the neonatal Malassezia folliculitis lesions on the face 3 , and given the outcome of this study in which the rate of identifying M. sympodialis in the twenties control group was lower than that in the patient group, the possibility of this strain being pathogenic may be questioned. Therefore, in order to identify the Malassezia species that play a major role in the pathogenesis and aggravation of Malassezia folliculitis, a large-scale quantitative analysis in future studies conducted on a larger patient pool and more variable sites of lesions may be needed.…”