Neonatal kaempferol exposure attenuates impact of cerebral palsy model on neuromotor development, cell proliferation, microglia activation, and antioxidant enzyme expression in the hippocampus of rats

Visco, Diego Bulcão; Manhães-de-Castro, Raul; Silva, Márcia Maria da; Santana, Bárbara Juacy Rodrigues Costa de; Santos, Joaci Pereira Dos; Saavedra, Luís Miguel; Lemos, Maria Daniele Teixeira Beltrão de; Valdéz-Alarcón, Juan José; Lagranha, Cláudia Jacques; Guzmán-Quevedo, Omar; Torner, Luz; Toscano, Ana Elisa

doi:10.1080/1028415x.2022.2156034

Cited by 10 publications

(6 citation statements)

References 99 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…During these phases, the offspring has a still developing blood-brain barrier, which facilitates the entry of effector molecules (i.e. pro-inflammatory mediators and reactive species) into the developing brain (Gouveia et al, 2023;Visco et al, 2022). Noteworthy, high-fat offspring (HFD and LPS+HFD)…”

Section: Discussionmentioning

confidence: 99%

“…However, other authors have already shown that this phenomenon can occur both during gestation and lactation. For example, some studies have shown that pro‐inflammatory cytokines can cross the placenta (Elfeky et al., 2017; Leirós et al., 2018), while others have observed their elevation in breast milk (Panagos et al., 2016; Pomar et al., 2017). Furthermore, the consumption of FDs during these periods may also exacerbate the passage of fatty acids through the same routes (placenta and breast milk), contributing to the accumulation of adipose tissue in the offspring and possibly promoting a pro‐inflammatory state (Leirós et al., 2018; Pomar et al., 2017).…”

Section: Discussionmentioning

confidence: 99%

“…During gestation, studies with humans or rodents have identified the passage of inflammatory mediators from mothers/dams to offspring through the placenta (Elfeky et al., 2017; Leirós et al., 2018). Similarly, during lactation, pro‐inflammatory cytokines were observed in breast milk (Panagos et al., 2016; Pomar et al., 2017).…”

Section: Introductionmentioning

confidence: 91%

“…Noteworthy, in early life (fetus or neonate), the blood-brain barrier is not fully developed, allowing the passage of effector molecules (i.e., pro-inflammatory cytokines and reactive oxygen species) to the brain (Gouveia et al, 2023;Visco et al, 2022). Therefore, maternal inflammation may contribute to disturbances in the offspring's brain structures, in particular those related to energy metabolism.…”

Section: Introductionmentioning

confidence: 99%

“…Among the mechanisms that establish this relationship, the maternal systemic inflammation appears as a possible trigger of metabolic disorders in the offspring. An important immunological alteration found in obesity is the establishment of low‐grade chronic inflammation, a condition that can also be found in obese mothers (Elfeky et al., 2017; Panagos et al., 2016). During gestation, studies with humans or rodents have identified the passage of inflammatory mediators from mothers/dams to offspring through the placenta (Elfeky et al., 2017; Leirós et al., 2018).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Maternal high‐fat diet associated with LPS gestational injection induces hypothalamic inflammation and metabolic disorders in male Wistar rat offspring

Rocha‐Gomes,

Escobar Teixeira,

da Silva

et al. 2024

Developmental Psychobiology

View full text Add to dashboard Cite

Maternal high‐fat diet (HFD) is linked to obesity and inflammation, predisposing offspring to metabolic and nutritional disorders. Accordingly, elevated blood levels of lipopolysaccharide (LPS) are also related to inflammation and metabolic complications in the offspring. The aim of this study was to evaluate the effects of the association of maternal HFD (gestation and lactation) and the LPS injection (gestation) on metabolic, inflammatory, and redox status parameters in male adolescent offspring. Female pregnant Wistar rats received randomly a standard or an HFD during gestation and lactation. On gestation Days 8, 10, and 12, half of the females in each group were intraperitonially injected with LPS (0.1 mg.kg−1). After weaning, all offspring received a standard diet. The dams and part of the male offspring were evaluated at weaning (Postnatal Day [PND] 21; food intake and inflammatory parameters), while the rest of the male offspring were evaluated during adolescence (PND50; food intake, redox status, and inflammatory parameters). HFD dams showed during gestation a lower weight gain. After lactation, HFD and LPS+HFD dams reported higher fat mass accumulation and increased interleukin‐6 (IL‐6) blood levels. HFD and LPS+HFD offspring showed at weaning higher levels of fat mass, body weight, and body length, besides an increased in hypothalamic IL‐6 levels. Noteworthy, at PND50, the LPS+HFD offspring showed higher energy intake, fat mass, and hypothalamic IL‐6 levels, in addition to an increased sucrose preference. Therefore, LPS+HFD offspring presented a worsening in energy metabolism, which was probably due to persistent hypothalamic inflammation, and also have a predisposition for the consumption of sweet foods.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Maternal high‐fat diet associated with LPS gestational injection induces hypothalamic inflammation and metabolic disorders in male Wistar rat offspring

Rocha‐Gomes,

Escobar Teixeira,

da Silva

et al. 2024

Developmental Psychobiology

View full text Add to dashboard Cite

show abstract

Current understanding and future directions of cruciferous vegetables and their phytochemicals to combat neurological diseases

Kakarla,

Karuturi,

Siakabinga

et al. 2024

Phytotherapy Research

View full text Add to dashboard Cite

Neurological disorders incidences are increasing drastically due to complex pathophysiology, and the nonavailability of disease‐modifying agents. Several attempts have been made to identify new potential chemicals to combat these neurological abnormalities. At present, complete abolishment of neurological diseases is not attainable except for symptomatic relief. However, dietary recommendations to help brain development or improvement have increased over the years. In recent times, cruciferous vegetables and their phytochemicals have been identified from preclinical and clinical investigations as potential neuroprotective agents. The present review highlights the beneficial effects and molecular mechanisms of phytochemicals such as indole‐3‐carbinol, diindolylmethane, sulforaphane, kaempferol, selenium, lutein, zeaxanthin, and vitamins of cruciferous vegetables against neurological diseases including Parkinson's disease, Alzheimer's disease, stroke, Huntington's disease, autism spectra disorders, anxiety, depression, and pain. Most of these cruciferous phytochemicals protect the brain by eliciting antioxidant, anti‐inflammatory, and antiapoptotic properties. Regular dietary intake of cruciferous vegetables may benefit the prevention and treatment of neurological diseases. The present review suggests that there is a lacuna in identifying the clinical efficacy of these phytochemicals. Therefore, high‐quality future studies should firmly establish the efficacy of the above‐mentioned cruciferous phytochemicals in clinical settings.

show abstract

Resveratrol Reduces Neuroinflammation and Hippocampal Microglia Activation and Protects Against Impairment of Memory and Anxiety-Like Behavior in Experimental Cerebral Palsy

Calado,

Manhães-de-Castro,

da Conceição Pereira

et al. 2023

Mol Neurobiol

View full text Add to dashboard Cite

Neonatal kaempferol exposure attenuates impact of cerebral palsy model on neuromotor development, cell proliferation, microglia activation, and antioxidant enzyme expression in the hippocampus of rats

Cited by 10 publications

References 99 publications

Maternal high‐fat diet associated with LPS gestational injection induces hypothalamic inflammation and metabolic disorders in male Wistar rat offspring

Maternal high‐fat diet associated with LPS gestational injection induces hypothalamic inflammation and metabolic disorders in male Wistar rat offspring

Current understanding and future directions of cruciferous vegetables and their phytochemicals to combat neurological diseases

Resveratrol Reduces Neuroinflammation and Hippocampal Microglia Activation and Protects Against Impairment of Memory and Anxiety-Like Behavior in Experimental Cerebral Palsy

Contact Info

Product

Resources

About