Neonatal hypoglycemia: A wide range of electroclinical manifestations and seizure outcomes

Arhan, Ebru; Öztürk, Zeynep; Serdaroğlu, Ayşe; Aydın, Kürşad; Hırfanoğlu, Tuğba; Akbaş, Yılmaz

doi:10.1016/j.ejpn.2017.05.009

Cited by 18 publications

(15 citation statements)

References 26 publications

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“…13 Early imaging examination of neonatal hypoglycemia is important for early detection and prognosis evaluation of brain injury. 14 Moreover, Arhan et al 15 found the results of MRI in the patients who developed epilepsy after neonatal hypoglycemia at the median age of 1.5 years, and the neuroradiological findings were gliosis in occipital WM bilaterally, occipital cortical atrophy, gliosis in the parietal WM, parietal cortical atrophy, or pulvinar scarring. This is different from the neonatal period.…”

Section: Discussionmentioning

confidence: 99%

Brain Injury in Neonatal Hypoglycemia: A Hospital-Based Cohort Study

Mei

Amanda

Yuan

2019

Clin Med Insights Pediatr

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Background: Neonatal hypoglycemia is more prevalent and can cause severe neurological sequelae. The objective of this study was to assess the patterns of neuroradiologic changes in neonatal hypoglycemia. Methods: A retrospective cohort study was conducted on 66 neonatal hypoglycemia patients, and the magnetic resonance imaging (MRI) and clinical records were reviewed. Results: Magnetic resonance imaging showed evidences of abnormality in 54.54% (36 of 66) of hypoglycemic infants. The most common abnormal findings were located on the parietal and occipital lobes of the brains. The number of days with hypoglycemia was significantly higher for abnormal MRI infants ( P < .001), and prolonged/recurrent hypoglycemia was remarkably distinguished for abnormal MRI infants ( P < .001). Patients with abnormal MRI findings did not have a lower blood glucose than infants without abnormal MRI findings ( P > .05), but the lowest blood glucose was significantly lower for the patients with seizures ( P < .01). Conclusions: The pattern of bilateral occipital cortical injury is the most common abnormality for neonatal hypoglycemia. The number of days with hypoglycemia, not the lower blood glucose, was significantly related to abnormal MRI infants.

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Section: Discussionmentioning

confidence: 99%

Brain Injury in Neonatal Hypoglycemia: A Hospital-Based Cohort Study

Mei

Amanda

Yuan

2019

Clin Med Insights Pediatr

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“…Clinical findings in infants after NH included visual impairments, cognitive deficits, and epilepsy. [24][25][26][27][28][29] The incidence of epilepsy in this situation was approximately 50%, and typical seizures in this situation were focal in nature with occipital origin. Infrequently, generalized tonic seizures were noted.…”

Section: Discussionmentioning

confidence: 99%

“…Infrequently, generalized tonic seizures were noted. 28,29 Herein, we present the case of a term newborn who suffered severe NH with consequent typical clinical and radiological findings and contextually developed an "acquired" Sylvian AC, discovered during radiological studies for epilepsy.…”

Section: Discussionmentioning

confidence: 99%

Can Neonatal Hypoglycemia be Considered a Risk Factor for Development of Acquired Arachnoid Cysts?

et al. 2017

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Arachnoid cysts (ACs) are intra-arachnoid fluid collections and may be classified as primary or secondary in nature. Neonatal hypoglycemia (NH) is a common, life-threatening metabolic disorder in infants. We present the case of a term infant who suffered severe NH within 72 hours after birth and subsequently developed an acquired Sylvian AC.A child of 13 months of age, with history of severe NH within 72 hours after birth, was admitted after two generalized seizures. Magnetic resonance imaging (MRI) of the brain showed dimensional increase of a left Sylvian AC, not present on imaging on day one of life but revealed with a second MRI at 16 days of age. The timeline of events suggests some kind of correlation between the newborn's metabolic disorder, appearance of the AC, and its progressive expansion. We speculate that NH's organic consequences, i.e., cortical and white matter atrophy might have favored some kind of cerebral spinal fluid (CSF) dynamic alteration and AC development in our patient. Further structured studies are needed to confirm our hypothesis and reveal NH as a risk factor in the pathogenesis of ACs.

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“…In one retrospective study of 45 patients between the age of 6 months and 15 years with a history of neonatal hypoglycemia with symptomatic seizures, 36 patients developed epilepsy, and of these, 23 had a medication-resistant form of epilepsy. 47 Brain MRI was obtained on all of these patients at a median age of 1.5 years, and all had gliosis in the occipital white matter bilaterally. Other small case studies have shown less severe outcomes.…”

Section: Hypoglycemiamentioning

confidence: 99%

Acute Seizures—Work-Up and Management in Children

Romantseva

Lin

2020

Semin Neurol

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Seizures are common in the pediatric population; however, most children do not go on to develop epilepsy later in life. Selecting appropriate diagnostic modalities to determine an accurate diagnosis and appropriate treatment as well as with counseling families regarding the etiology and prognosis of seizures, is essential. This article will review updated definitions of seizures, including provoked versus unprovoked, as well as the International League Against Epilepsy operational definition of epilepsy. A variety of specific acute symptomatic seizures requiring special consideration are discussed, along with neonatal seizures and seizure mimics, which are common in pediatric populations.

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Neonatal hypoglycemia: A wide range of electroclinical manifestations and seizure outcomes

Cited by 18 publications

References 26 publications

Brain Injury in Neonatal Hypoglycemia: A Hospital-Based Cohort Study

Brain Injury in Neonatal Hypoglycemia: A Hospital-Based Cohort Study

Can Neonatal Hypoglycemia be Considered a Risk Factor for Development of Acquired Arachnoid Cysts?

Acute Seizures—Work-Up and Management in Children

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