Neonatal hyperbilirubinemia and childhood allergic diseases: a systematic review

Das, Rashmi Ranjan; Ss, Naik

doi:10.1111/pai.12281

Cited by 25 publications

(29 citation statements)

References 24 publications

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“…A meta-analysis of seven studies (six retrospective studies and one cohort study) including 101,499 children 18 showed that neonatal hyperbilirubinemia significantly increased the odds of childhood asthma (OR=4.26), without heterogeneity across studies. Neonatal phototherapy also increased the odds of asthma (OR=3.81) with low heterogeneity.…”

Section: Perinatal Factors (Figure 2b)mentioning

confidence: 99%

Risk and Protective Factors for Childhood Asthma: What Is the Evidence?

Castro-Rodriguez

Forno

Rodríguez‐Martínez

et al. 2016

The Journal of Allergy and Clinical Immunology: In Practice

215

210

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In order to summarize the principal findings on risk and protective factors for childhood asthma, we retrieved systematic reviews on these topics in children (ages 1 to 18 years), up to January 2016, through MEDLINE, EMBASE, CINAHL, SCOPUS and CDSR. Two hundred twenty seven studies were searched from databases. Among those, 41 systematic reviews (SRs) were included: 9 focused on prenatal factors, 5 on perinatal factors, and 27 on postnatal factors. Of these 41 SRs, 83% had good methodological quality, as determined by the AMSTAR tool. After reviewing all evidence, parental asthma, prenatal environmental tobacco smoke and prematurity (particularly very preterm birth) are well-established risk factors for childhood asthma. Current findings do suggest mild to moderate causal effects of certain modifiable behaviors or exposures during pregnancy (maternal weight gain or obesity, maternal use of antibiotics or paracetamol, and maternal stress), the perinatal period (birth by Caesarean delivery), or postnatal life (severe RSV infection, overweight or obesity, indoor exposure to mold or fungi, and outdoor air pollution) on childhood asthma, but this suggestive evidence must be confirmed in interventional studies or (if interventions are not feasible) well-designed prospective studies.

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Section: Perinatal Factors (Figure 2b)mentioning

confidence: 99%

Risk and Protective Factors for Childhood Asthma: What Is the Evidence?

Castro-Rodriguez

Forno

Rodríguez‐Martínez

et al. 2016

The Journal of Allergy and Clinical Immunology: In Practice

215

210

View full text Add to dashboard Cite

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“…Accordingly, neonatal jaundice was associated with the development of allergic diseases, mostly allergic rhinitis and AD, in a population‐based study . Furthermore, this risk was linked with high bilirubin levels requiring phototherapy . The pathophysiology of the relationship between neonatal jaundice and allergic consequences remains unclear and warrants further exploration.…”

Section: Perinatal Influencesmentioning

confidence: 99%

Food allergy and atopic dermatitis: Prediction, progression, and prevention

Mastrorilli

Caffarelli

Hoffmann‐Sommergruber

2017

Pediatric Allergy Immunology

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The rising burden of allergic diseases in childhood requires a compelling need to identify individuals at risk for atopy very early in life or even predict the onset of food allergy and atopic dermatitis since pregnancy. The development and clinical phenotypes of atopic diseases in childhood depend on a complex interaction between genetic and environmental factors, such as allergen exposure, air pollution, and infections. Preventive strategies may include avoidance measures, diet supplements, and early complementary food introduction. Overall, the management of allergic diseases has been improving to date toward a patient's tailored approach. This review will cover the current understanding of risk factors, prediction, and management of food allergy and atopic dermatitis in childhood and discuss how these may contribute to the modification of the natural history of food allergy and atopic dermatitis.

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“…Additionally, previous studies could not find an association between phototherapy and skin cancer [16,19]. Phototherapy does seem to be associated with the development of allergic diseases [20].…”

Section: Intensive Phototherapymentioning

confidence: 99%

Neonatal management and outcome in alloimmune hemolytic disease

Ree

Smits-Wintjens

Bom

et al. 2017

Expert Review of Hematology

103

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Introduction: Hemolytic disease of the fetus and newborn (HDFN) occurs when fetal and neonatal erythroid cells are destroyed by maternal erythrocyte alloantibodies, it leads to anemia and hydrops in the fetus, and hyperbilirubinemia and kernicterus in the newborn. Postnatal care consists of intensive phototherapy and exchange transfusions to treat severe hyperbilirubinemia and top-up transfusions to treat early and late anemia. Other postnatal complications have been reported such as thrombocytopenia, iron overload and cholestasis requiring specific management. Areas covered: This review focusses on the current neonatal management and outcome of hemolytic disease and discusses postnatal treatment options as well as literature on long-term neurodevelopmental outcome. Expert commentary: Despite major advances in neonatal management, multiple issues have to be addressed to optimize postnatal management and completely eradicate kernicterus. Except for strict adherence to guidelines, improvement could be achieved by clarifying the epidemiology and pathophysiology of HDFN. Several pharmacotherapeutic agents should be further researched as alternative treatment options in hyperbilirubinemia, including immunoglobulins, albumin, phenobarbital, metalloporphyrins, zinc, clofibrate and prebiotics. Larger trials are warranted to evaluate EPO, folate and vitamin E in neonates. Long-term follow-up studies are needed in HDFN, especially on thrombocytopenia, iron overload and cholestasis.ARTICLE HISTORY

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Neonatal hyperbilirubinemia and childhood allergic diseases: a systematic review

Cited by 25 publications

References 24 publications

Risk and Protective Factors for Childhood Asthma: What Is the Evidence?

Risk and Protective Factors for Childhood Asthma: What Is the Evidence?

Food allergy and atopic dermatitis: Prediction, progression, and prevention

Neonatal management and outcome in alloimmune hemolytic disease

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