Neonatal Hepatitis and Extrahepatic Biliary Atresia Associated With Cytomegalovirus Infection in Twins

Immunoglobulin deposits in liver tissue from infants with biliary atresia and the correlation to cytomegalovirus infection

“…Serologic evidence for ongoing CMV infection in patients with BA has been reported by other groups [7,8,11], and we found a significantly higher incidence of such evidence in patients with BA than in age-matched controls [5]. Furthermore, we detected CMV-DNA by PCR in liver tissue from 9 of 18 investigated patients [5].…”

Immunoglobulin deposits in liver tissue from infants with biliary atresia and the correlation to cytomegalovirus infection

“…Serologic evidence for ongoing CMV infection in patients with BA has been reported by other groups [7,8,11], and we found a significantly higher incidence of such evidence in patients with BA than in age-matched controls [5]. Furthermore, we detected CMV-DNA by PCR in liver tissue from 9 of 18 investigated patients [5].…”

Cytomegalovirus hepatitis: characterization of the inflammatory infiltrate in resistant and susceptible mice

“…However, little is known about the long-term effects of HCMV infection in the liver. Neonatal HCMV hepatitis may lead to fibrosis and extrahepatic biliary atresia [5,6], and hepatomegaly may persist for at least 3 years [7]. The persistence of inflammatory cells in the livers of our mice was not associated with necrosis or fibrosis up to 33 weeks p.i., but the model is appropriate for longer term studies.…”

The Viral Association of Neonatal Cholestasis in Sweden: A Possible Link Between Cytomegalovirus Infection and Extrahepatic Biliary Atresia

“…Cytomegalovirus has been associated with EHBA in earlier case reports(4‐6). The possibility that more than one virus is linked to EHBA is in accordance with the hypothesis that EHBA is caused by genetic vulnerability‐for example of HLA type‐to different precipitating factors, of viral or other origin (7,8).…”

Immunoglobulin deposits in liver tissue from infants with biliary atresia and the correlation to cytomegalovirus infection

“…Serologic evidence for ongoing CMV infection in patients with BA has been reported by other groups [7,8,11], and we found a significantly higher incidence of such evidence in patients with BA than in age-matched controls [5]. Furthermore, we detected CMV-DNA by PCR in liver tissue from 9 of 18 investigated patients [5].…”

Cytomegalovirus hepatitis: characterization of the inflammatory infiltrate in resistant and susceptible mice

“…However, little is known about the long-term effects of HCMV infection in the liver. Neonatal HCMV hepatitis may lead to fibrosis and extrahepatic biliary atresia [5,6], and hepatomegaly may persist for at least 3 years [7]. The persistence of inflammatory cells in the livers of our mice was not associated with necrosis or fibrosis up to 33 weeks p.i., but the model is appropriate for longer term studies.…”

The Viral Association of Neonatal Cholestasis in Sweden: A Possible Link Between Cytomegalovirus Infection and Extrahepatic Biliary Atresia

“…Cytomegalovirus has been associated with EHBA in earlier case reports(4‐6). The possibility that more than one virus is linked to EHBA is in accordance with the hypothesis that EHBA is caused by genetic vulnerability‐for example of HLA type‐to different precipitating factors, of viral or other origin (7,8).…”

Immunoglobulin deposits in liver tissue from infants with biliary atresia and the correlation to cytomegalovirus infection

“…Serologic evidence for ongoing CMV infection in patients with BA has been reported by other groups [7,8,11], and we found a significantly higher incidence of such evidence in patients with BA than in age-matched controls [5]. Furthermore, we detected CMV-DNA by PCR in liver tissue from 9 of 18 investigated patients [5].…”

Cytomegalovirus hepatitis: characterization of the inflammatory infiltrate in resistant and susceptible mice

“…However, little is known about the long-term effects of HCMV infection in the liver. Neonatal HCMV hepatitis may lead to fibrosis and extrahepatic biliary atresia [5,6], and hepatomegaly may persist for at least 3 years [7]. The persistence of inflammatory cells in the livers of our mice was not associated with necrosis or fibrosis up to 33 weeks p.i., but the model is appropriate for longer term studies.…”

The Viral Association of Neonatal Cholestasis in Sweden: A Possible Link Between Cytomegalovirus Infection and Extrahepatic Biliary Atresia

“…Cytomegalovirus has been associated with EHBA in earlier case reports(4‐6). The possibility that more than one virus is linked to EHBA is in accordance with the hypothesis that EHBA is caused by genetic vulnerability‐for example of HLA type‐to different precipitating factors, of viral or other origin (7,8).…”