International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations. We report a case series of three neonates diagnosed with gastric perforations in the first week of life and successfully managed by urgent surgical intervention. All three patients had associated gastrointestinal anomalies contributing to the gastric perforation. Conclusion: Neonatal gastric perforation is extremely rare and is associated with high mortality. Early diagnosis and prompt surgical intervention are essential to improve the outcomes.