Neonatal exposure to 3,3′,4,4′-tetrachlorobiphenyl: changes in spontaneous behaviour and cholinergic muscarinic receptors in the adult mouse

Brominated Flame Retardants: A Novel Class of Developmental Neurotoxicants in Our Environment?

“…Habituation-a decrease in locomotion, rearing, and total activity variables in response to the diminishing novelty of the test chamber over 60 min-was demonstrated in the control animals, but mice treated with PBDE 99 and PBDE 47 were obviously hypoactive early in the 60-min test period, whereas toward the end they became hyperactive. This nonhabituating behavior profile has also been reported in adult mice neonatally exposed to ortho-substituted PCBs, such as PCB 28, PCB 52, PCB 153 (24,38,39), and also in mice neonatally exposed to coplanar PCBs, such as PCB 77, PCB 126, and PCB 169 (24,40,41). This indicates that some PBDEs can be potent inducers of behavioral aberrations and that the changes can be similar to those observed earlier for some ortho-and coplanar PCBs.…”

Brominated Flame Retardants: A Novel Class of Developmental Neurotoxicants in Our Environment?

“…Habituation-a decrease in locomotion, rearing, and total activity variables in response to the diminishing novelty of the test chamber over 60 min-was demonstrated in the control animals, but mice treated with PBDE 99 and PBDE 47 were obviously hypoactive early in the 60-min test period, whereas toward the end they became hyperactive. This nonhabituating behavior profile has also been reported in adult mice neonatally exposed to ortho-substituted PCBs, such as PCB 28, PCB 52, PCB 153 (24,38,39), and also in mice neonatally exposed to coplanar PCBs, such as PCB 77, PCB 126, and PCB 169 (24,40,41). This indicates that some PBDEs can be potent inducers of behavioral aberrations and that the changes can be similar to those observed earlier for some ortho-and coplanar PCBs.…”

Human prenatal and postnatal exposure to polybrominated diphenyl ethers, polychlorinated biphenyls, polychlorobiphenylols, and pentachlorophenol.

“…Furthermore, it has been shown that exposure of mice to BDE-47 and BDE-99 during the critical neonatal period causes neurotoxic effects in adult animals (Eriksson et al 2001;Viberg et al 2002). Similar effects have previously been reported for certain coplanar and ortho-substituted PCBs (Eriksson and Fredriksson 1996a, 1996bEriksson et al 1991). In addition, effects of prenatal and postnatal exposure to PCBs, such as lower gestational age and birth weight (Fein et al 1984;Rylander et al 2000;Taylor et al 1984), delayed development (Guo et al 1994), and intellectual impairment (Jacobson and Jacobson 1996), have been reported in humans.…”

Neurobehavioral Derangements in Adult Mice Receiving Decabrominated Diphenyl Ether (PBDE 209) during a Defined Period of Neonatal Brain Development

“…Normal habituation, defined here as a decrease in the variables locomotion, rearing, and total activity, in response to the diminished novelty of the test chamber over a 60-min test period, divided into three 20-min periods, was seen in the control mice treated on neonatal day 3, 10, or 19 with the 20% fat emulsion vehicle. This normal habituation profile has been seen in a vast number of experiments conducted by the research group of Eriksson over the last 12 years (Eriksson, 1997(Eriksson, , 1998Eriksson et al, 1991Eriksson et al, , 2000Eriksson et al, , 2001bEriksson et al, , 2002Viberg et al, 2002, in press).…”

Brominated Flame Retardants: A Novel Class of Developmental Neurotoxicants in Our Environment?

“…Habituation-a decrease in locomotion, rearing, and total activity variables in response to the diminishing novelty of the test chamber over 60 min-was demonstrated in the control animals, but mice treated with PBDE 99 and PBDE 47 were obviously hypoactive early in the 60-min test period, whereas toward the end they became hyperactive. This nonhabituating behavior profile has also been reported in adult mice neonatally exposed to ortho-substituted PCBs, such as PCB 28, PCB 52, PCB 153 (24,38,39), and also in mice neonatally exposed to coplanar PCBs, such as PCB 77, PCB 126, and PCB 169 (24,40,41). This indicates that some PBDEs can be potent inducers of behavioral aberrations and that the changes can be similar to those observed earlier for some ortho-and coplanar PCBs.…”

Human prenatal and postnatal exposure to polybrominated diphenyl ethers, polychlorinated biphenyls, polychlorobiphenylols, and pentachlorophenol.

“…Furthermore, it has been shown that exposure of mice to BDE-47 and BDE-99 during the critical neonatal period causes neurotoxic effects in adult animals (Eriksson et al 2001;Viberg et al 2002). Similar effects have previously been reported for certain coplanar and ortho-substituted PCBs (Eriksson and Fredriksson 1996a, 1996bEriksson et al 1991). In addition, effects of prenatal and postnatal exposure to PCBs, such as lower gestational age and birth weight (Fein et al 1984;Rylander et al 2000;Taylor et al 1984), delayed development (Guo et al 1994), and intellectual impairment (Jacobson and Jacobson 1996), have been reported in humans.…”

Neurobehavioral Derangements in Adult Mice Receiving Decabrominated Diphenyl Ether (PBDE 209) during a Defined Period of Neonatal Brain Development

“…Normal habituation, defined here as a decrease in the variables locomotion, rearing, and total activity, in response to the diminished novelty of the test chamber over a 60-min test period, divided into three 20-min periods, was seen in the control mice treated on neonatal day 3, 10, or 19 with the 20% fat emulsion vehicle. This normal habituation profile has been seen in a vast number of experiments conducted by the research group of Eriksson over the last 12 years (Eriksson, 1997(Eriksson, , 1998Eriksson et al, 1991Eriksson et al, , 2000Eriksson et al, , 2001bEriksson et al, , 2002Viberg et al, 2002, in press).…”

Brominated Flame Retardants: A Novel Class of Developmental Neurotoxicants in Our Environment?

“…Habituation-a decrease in locomotion, rearing, and total activity variables in response to the diminishing novelty of the test chamber over 60 min-was demonstrated in the control animals, but mice treated with PBDE 99 and PBDE 47 were obviously hypoactive early in the 60-min test period, whereas toward the end they became hyperactive. This nonhabituating behavior profile has also been reported in adult mice neonatally exposed to ortho-substituted PCBs, such as PCB 28, PCB 52, PCB 153 (24,38,39), and also in mice neonatally exposed to coplanar PCBs, such as PCB 77, PCB 126, and PCB 169 (24,40,41). This indicates that some PBDEs can be potent inducers of behavioral aberrations and that the changes can be similar to those observed earlier for some ortho-and coplanar PCBs.…”

Human prenatal and postnatal exposure to polybrominated diphenyl ethers, polychlorinated biphenyls, polychlorobiphenylols, and pentachlorophenol.

“…Furthermore, it has been shown that exposure of mice to BDE-47 and BDE-99 during the critical neonatal period causes neurotoxic effects in adult animals (Eriksson et al 2001;Viberg et al 2002). Similar effects have previously been reported for certain coplanar and ortho-substituted PCBs (Eriksson and Fredriksson 1996a, 1996bEriksson et al 1991). In addition, effects of prenatal and postnatal exposure to PCBs, such as lower gestational age and birth weight (Fein et al 1984;Rylander et al 2000;Taylor et al 1984), delayed development (Guo et al 1994), and intellectual impairment (Jacobson and Jacobson 1996), have been reported in humans.…”

Neurobehavioral Derangements in Adult Mice Receiving Decabrominated Diphenyl Ether (PBDE 209) during a Defined Period of Neonatal Brain Development

“…Normal habituation, defined here as a decrease in the variables locomotion, rearing, and total activity, in response to the diminished novelty of the test chamber over a 60-min test period, divided into three 20-min periods, was seen in the control mice treated on neonatal day 3, 10, or 19 with the 20% fat emulsion vehicle. This normal habituation profile has been seen in a vast number of experiments conducted by the research group of Eriksson over the last 12 years (Eriksson, 1997(Eriksson, , 1998Eriksson et al, 1991Eriksson et al, , 2000Eriksson et al, , 2001bEriksson et al, , 2002Viberg et al, 2002, in press).…”