Neonatal congenital lung tumors — the importance of mid-second-trimester ultrasound as a diagnostic clue

Waelti, Stephan; Garel, Laurent; Soglio, Dorothée Dal; Rypens, Françoise; Messerli, Michael; Dubois, Josée

doi:10.1007/s00247-017-3953-3

Cited by 27 publications

(38 citation statements)

References 40 publications

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“…Important considerations for evaluation of masses in patients of this age group include fetal US data, if available, and the presence of air-filled cysts. Developmental lung lesions are typically present on images acquired at mid-second-trimester US, whereas primary lung tumors should be suspected when a lung mass is discovered in a neonate or infant with normal mid-secondtrimester fetal US results (6). On the other hand, congenital lesions without large cysts may go undetected at US during the second trimester because they appear similar to fetal lung tissue.…”

Section: Lung Tumors In Neonates and Infantsmentioning

confidence: 99%

“…PPB is the most common primary lung malignancy in children but is, overall, a rare neoplasm, representing only 0.25%-0.50% of all primary lung malignancies (6,7). The tumor occurs primarily in children younger than 6 years (8).…”

Section: Pleuropulmonary Blastomamentioning

confidence: 99%

“…On the basis of information gathered from the International Pleuropulmonary Blastoma Registry, strong evidence shows that the types of PPB form stages of a continuum with progression from type 1 to type 3. The median age at diagnosis correlates with the subtype of PPB, with the median age for types 1, 2, and 3 being 10 months, 34 months, and 44 months, respectively (6,(9)(10)(11).…”

Section: Pleuropulmonary Blastomamentioning

confidence: 99%

“…The most common presenting symptoms in children with IMT are cough, fever, chest pain, and hemoptysis. nephroma, pineoblastoma, pituitary blastoma, differentiated thyroid cancer, ovarian sex cord-stromal tumors, embryonal rhabdomyosarcomas, and other rare tumors (6,12).…”

Section: Pleuropulmonary Blastomamentioning

confidence: 99%

“…Type 3 PPB shows increased fluorodeoxyglucose (FDG) uptake at FDG PET/CT (18). Pleural effusion and pneumothorax are frequently associated findings in PPB (6,14,16). Metastatic disease most commonly occurs to the skeletal system and central nervous system (2,17).…”

Section: Pleuropulmonary Blastomamentioning

confidence: 99%

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Primary Lung Tumors in Children: Radiologic-Pathologic CorrelationFrom the Radiologic Pathology Archives

Lichtenberger¹,

Biko²,

Carter³

et al. 2018

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Primary lung tumors in children are rare, with a narrow range of diagnostic considerations. However, the overlapping imaging appearances of these tumors necessitate attention to key discriminating imaging and pathologic features. In the neonate and infant, the important considerations include pleuropulmonary blastoma (PPB), infantile fibrosarcoma, and fetal lung interstitial tumor. Among these tumors, imaging findings such as air-filled cysts in type 1 PPB and homogeneously low attenuation of fetal lung interstitial tumors are relatively specific. Key pathologic and genetic discriminators among this group of tumors include the DICER1 germline mutation found in PPB and the t(12,15)(p13;q25) translocation and ETV6-NTRK3 fusion gene seen in infantile fibrosarcoma. Primary lung tumors in older children include inflammatory myofibroblastic tumors (IMTs), carcinoid salivary gland-type tumors of the lung, recurrent respiratory papillomatosis, and other rare entities. IMT, a spindle-cell proliferation with inflammatory elements, is the most common lung tumor in children. Anaplastic lymphoma kinase, a receptor-type protein tyrosine kinase, is present in 50% of these tumors, and this finding may support an imaging diagnosis of IMT. Carcinoid tumors account for a substantial portion of childhood lung tumors, and their characteristic avid enhancement on images corresponds to the compressed fibrovascular stroma histologically. Furthermore, novel imaging agents used with somatostatin receptor analogs have an emerging role in the evaluation of carcinoid tumors. Although less common than mucoepidermoid carcinoma, adenoid cystic carcinoma tends to recur given the perineural spread seen histologically. Integrating radiologic and pathologic knowledge is critical to accurate diagnosis, treatment planning, and surveillance of primary lung tumors in children.Abbreviations: CPAM = congenital pulmonary airway malformation, FDG = fluorodeoxyglucose, FLIT = fetal lung interstitial tumor, GLUT1 = glucose transporter 1, IMT = inflammatory myofibroblastic tumor, NUT = nuclear protein in testis, PPB = pleuropulmonary blastoma, RRP = recurrent respiratory papillomatosis

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Section: Lung Tumors In Neonates and Infantsmentioning

confidence: 99%

Section: Pleuropulmonary Blastomamentioning

confidence: 99%

Section: Pleuropulmonary Blastomamentioning

confidence: 99%

Section: Pleuropulmonary Blastomamentioning

confidence: 99%

Section: Pleuropulmonary Blastomamentioning

confidence: 99%

See 3 more Smart Citations

Primary Lung Tumors in Children: Radiologic-Pathologic CorrelationFrom the Radiologic Pathology Archives

Lichtenberger¹,

Biko²,

Carter³

et al. 2018

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Imaging of fetal tumors and other dysplastic lesions: A review with emphasis on MR imaging

et al. 2020

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Fetal tumors and other dysplastic masses are relatively rare. They are usually the result of failure of differentiation and maturation during embryonic or fetal life; dysplastic lesions may be the consequence of an obstruction sequence. In this review, we present the most commonly encountered tumors and masses seen during fetal life. Imaging characteristics, tumoral organ of origin, and its effect on the surrounding organs and overall fetal hemodynamics are descriptors that must be relayed to the fetal surgeon and maternal fetal medicine expert, in order to institute most accurate parental counseling and appropriate perinatal treatment plan.

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Fetal Chest

Bulas¹,

Egloff²

2019

Imaging in Pediatric Pulmonology

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Neonatal congenital lung tumors — the importance of mid-second-trimester ultrasound as a diagnostic clue

Cited by 27 publications

References 40 publications

Primary Lung Tumors in Children: Radiologic-Pathologic CorrelationFrom the Radiologic Pathology Archives

Primary Lung Tumors in Children: Radiologic-Pathologic CorrelationFrom the Radiologic Pathology Archives

Imaging of fetal tumors and other dysplastic lesions: A review with emphasis on MR imaging

Fetal Chest

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