Neonatal chlamydial conjunctivitis.

Abstract

SUMMARY Maternal chlamydial antibodies were determined in cord sera of 41 infants who developed neonatal chlamydial conjunctivitis and compared with the antibody profile of infants who had been exposed to Chlamydia trachomatis at birth by their isolation positive mothers but in whom conjunctivitis did not develop. No protective effect could be attributed to maternal antibodies transferred to the infants. Paired sera samples were collected from 18 infants with chlamydial conjunctivitis. Chlamydial IgM antibodies were detected in four of these 18 cases at the time diagnosis was established by isolation. An additional eight cases had developed chlamydial IgM at the time the convalescent sera samples were taken, on average on day 40. At that time symptoms had disappeared after systemic treatment had been given. Thus chlamydial IgM antibodies were eventually shown in two thirds of infants with chlamydial conjunctivitis who were all systemically treated and clinically healed. These data suggest a cautious assessment of chlamydial IgM in the diagnosis of chlamydial pneumonia.

Maternal immunity partially protects newborn mice against a Chlamydia trachomatis intranasal challenge

“…Persson et al (1986) determined maternal chlamydial antibodies in cord sera of 41 infants with nenonatal C. trachomatis conjunctivitis. As a control, they used 16 infants with no conjunctivitis but whose mothers had genital chlamydial genital infection at the time of delivery.…”

“…Approximately 30% of the infants exposed to C. trachomatis in the birth canal develop conjunctivitis and 10% to 20% show symptoms of pneumonia (Numazaki, et al, 2003; Persson, et al, 1986; Schachter and Caldwell, 1980). A total of 75,000 cases of inclusion conjunctivitis and 30,000 cases of C. trachomatis pneumonia are reported each year (Persson, et al, 1986; Schachter and Caldwell, 1980). In addition, newborns may have vaginal and gastrointestinal tract infections with no known clinical consequences (Schachter and Caldwell, 1980).…”

“…If diagnosed in time, most of the neonatal infections can be treated with antibiotics, and there are no long-term sequelae. However, some neonates develop persistent infections (Darville, 2005; Persson, et al, 1986). …”

Maternal immunity partially protects newborn mice against a Chlamydia trachomatis intranasal challenge

“…Persson et al (1986) determined maternal chlamydial antibodies in cord sera of 41 infants with nenonatal C. trachomatis conjunctivitis. As a control, they used 16 infants with no conjunctivitis but whose mothers had genital chlamydial genital infection at the time of delivery.…”

“…Approximately 30% of the infants exposed to C. trachomatis in the birth canal develop conjunctivitis and 10% to 20% show symptoms of pneumonia (Numazaki, et al, 2003; Persson, et al, 1986; Schachter and Caldwell, 1980). A total of 75,000 cases of inclusion conjunctivitis and 30,000 cases of C. trachomatis pneumonia are reported each year (Persson, et al, 1986; Schachter and Caldwell, 1980). In addition, newborns may have vaginal and gastrointestinal tract infections with no known clinical consequences (Schachter and Caldwell, 1980).…”

“…If diagnosed in time, most of the neonatal infections can be treated with antibiotics, and there are no long-term sequelae. However, some neonates develop persistent infections (Darville, 2005; Persson, et al, 1986). …”

Mechanism of T-cell mediated protection in newborn mice against a Chlamydia infection

“…If Chlamydia is not diagnosed and treated during pregnancy the babies could acquire the infection from their mothers. About one in three of the exposed infants develop inclusion conjunctivitis while approximately one in six are affected with pneumonia [2-4]. Infections of the genitourinary and gastrointestinal tracts of newborns have also been reported [3].…”

“…Neonatal chlamydial infections can be treated with antibiotics. However, in spite of antibiotic treatment, some neonates develop persistent infections [4, 6]. …”

Maternal immunity partially protects newborn mice against a Chlamydia trachomatis intranasal challenge

“…Persson et al (1986) determined maternal chlamydial antibodies in cord sera of 41 infants with nenonatal C. trachomatis conjunctivitis. As a control, they used 16 infants with no conjunctivitis but whose mothers had genital chlamydial genital infection at the time of delivery.…”

“…Approximately 30% of the infants exposed to C. trachomatis in the birth canal develop conjunctivitis and 10% to 20% show symptoms of pneumonia (Numazaki, et al, 2003; Persson, et al, 1986; Schachter and Caldwell, 1980). A total of 75,000 cases of inclusion conjunctivitis and 30,000 cases of C. trachomatis pneumonia are reported each year (Persson, et al, 1986; Schachter and Caldwell, 1980). In addition, newborns may have vaginal and gastrointestinal tract infections with no known clinical consequences (Schachter and Caldwell, 1980).…”

“…If diagnosed in time, most of the neonatal infections can be treated with antibiotics, and there are no long-term sequelae. However, some neonates develop persistent infections (Darville, 2005; Persson, et al, 1986). …”

Mechanism of T-cell mediated protection in newborn mice against a Chlamydia infection

“…If Chlamydia is not diagnosed and treated during pregnancy the babies could acquire the infection from their mothers. About one in three of the exposed infants develop inclusion conjunctivitis while approximately one in six are affected with pneumonia [2-4]. Infections of the genitourinary and gastrointestinal tracts of newborns have also been reported [3].…”

“…Neonatal chlamydial infections can be treated with antibiotics. However, in spite of antibiotic treatment, some neonates develop persistent infections [4, 6]. …”

Maternal immunity partially protects newborn mice against a Chlamydia trachomatis intranasal challenge

“…Persson et al (1986) determined maternal chlamydial antibodies in cord sera of 41 infants with nenonatal C. trachomatis conjunctivitis. As a control, they used 16 infants with no conjunctivitis but whose mothers had genital chlamydial genital infection at the time of delivery.…”

“…Approximately 30% of the infants exposed to C. trachomatis in the birth canal develop conjunctivitis and 10% to 20% show symptoms of pneumonia (Numazaki, et al, 2003; Persson, et al, 1986; Schachter and Caldwell, 1980). A total of 75,000 cases of inclusion conjunctivitis and 30,000 cases of C. trachomatis pneumonia are reported each year (Persson, et al, 1986; Schachter and Caldwell, 1980). In addition, newborns may have vaginal and gastrointestinal tract infections with no known clinical consequences (Schachter and Caldwell, 1980).…”

“…If diagnosed in time, most of the neonatal infections can be treated with antibiotics, and there are no long-term sequelae. However, some neonates develop persistent infections (Darville, 2005; Persson, et al, 1986). …”

Mechanism of T-cell mediated protection in newborn mice against a Chlamydia infection

“…If Chlamydia is not diagnosed and treated during pregnancy the babies could acquire the infection from their mothers. About one in three of the exposed infants develop inclusion conjunctivitis while approximately one in six are affected with pneumonia [2-4]. Infections of the genitourinary and gastrointestinal tracts of newborns have also been reported [3].…”

“…Neonatal chlamydial infections can be treated with antibiotics. However, in spite of antibiotic treatment, some neonates develop persistent infections [4, 6]. …”