2010
DOI: 10.1523/jneurosci.5656-08.2010
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Abstract: Ocular dominance plasticity (ODP) following monocular deprivation (MD) is a model of activity-dependent neural plasticity that is

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Cited by 57 publications
(65 citation statements)
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“…As previously reported by others,12,13 a large variability in the severity of the pathological changes was apparent (Fig. 1A–C).…”
Section: Resultssupporting
confidence: 88%
“…As previously reported by others,12,13 a large variability in the severity of the pathological changes was apparent (Fig. 1A–C).…”
Section: Resultssupporting
confidence: 88%
“…The injury variability within the model is wide; [29][30][31] therefore, large treatment groups have to be used. However, this experimental weakness strengthens the translational value of the model, because it reproduces variability observed in human neonatal HI.…”
Section: Discussionmentioning
confidence: 99%
“…Because enhanced activity supports synaptic plasticity and learning (50) and reduced activity might prevent experiencedependent changes in neuronal circuitry, diminished plasticity in the lesioned, and present or even enhanced plasticity in the nonlesioned hemisphere of PT-animals, might be at least partly due to changes in activity levels. Recently, Failor et al (51) also concluded that OD-plasticity may be uniquely dependent upon precise regulation of cortical activation: In mice with moderate cortical injury following neonatal hypoxia-ischemia, impaired OD-plasticity was correlated with a loss of parvalbumin expression, modifying excitation-inhibition balance.…”
Section: Discussionmentioning
confidence: 99%