Neo-striatal rCBF correlates of psychomotor slowing in patients with major depression

Hickie, Ian B.; Ward, Philip B.; Scott, Elizabeth; Haindl, Walter; Walker, Beth; Dixon, Jennifer A.; Turner, K. Amber

doi:10.1016/s0925-4927(99)00038-4

Cited by 58 publications

(26 citation statements)

References 27 publications

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“…Results of these studies revealed resting abnormalities in the dorsolateral, ventrolateral, and medial aspects of the prefrontal cortex and the anterior cingulate, blunted responses in the anterior cingulate and medial prefrontal cortex to behavioral and pharmacological challenges, and abnormalities localized to the orbitofrontal cortex (100,101). Lower activity in the striatum of depressed patients in the resting state and in response to a reaction-time task and feedback have also been reported (102,103).…”

Section: Dysthymiamentioning

confidence: 99%

Drug Addiction and Its Underlying Neurobiological Basis: Neuroimaging Evidence for the Involvement of the Frontal Cortex

Goldstein

Volkow²

2002

AJP

2,325

102

1,717

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Objective-Studies of the neurobiological processes underlying drug addiction primarily have focused on limbic subcortical structures. Here the authors evaluated the role of frontal cortical structures in drug addiction.Method-An integrated model of drug addiction that encompasses intoxication, bingeing, withdrawal, and craving is proposed. This model and findings from neuroimaging studies on the behavioral, cognitive, and emotional processes that are at the core of drug addiction were used to analyze the involvement of frontal structures in drug addiction. Results-The orbitofrontal cortex and the anterior cingulate gyrus, which are regions neuroanatomically connected with limbic structures, are the frontal cortical areas most frequently implicated in drug addiction. They are activated in addicted subjects during intoxication, craving, and bingeing, and they are deactivated during withdrawal. These regions are also involved in higherorder cognitive and motivational functions, such as the ability to track, update, and modulate the salience of a reinforcer as a function of context and expectation and the ability to control and inhibit prepotent responses.Conclusions-These results imply that addiction connotes cortically regulated cognitive and emotional processes, which result in the overvaluing of drug reinforcers, the undervaluing of alternative reinforcers, and deficits in inhibitory control for drug responses. These changes in addiction, which the authors call I-RISA (impaired response inhibition and salience attribution), expand the traditional concepts of drug dependence that emphasize limbic-regulated responses to pleasure and reward.Addiction is a complex disease process of the brain that results from recurring drug intoxication and is modulated by genetic, developmental, experiential, and environmental factors. The neurobiological changes that accompany drug addiction are not well understood. While until recently it was believed that addiction predominantly involved reward processes mediated by limbic circuits (see, for example, the reward deficiency syndrome [1]), results from recent neuroimaging studies have implicated additional brain areas, especially the frontal cortex. Here we summarize the findings from these neuroimaging studies and incorporate them with pertinent results from preclinical studies in suggesting a basis for an integrated model of drug addiction.Most imaging studies have concentrated on the involvement of dopamine in the process of drug addiction because the ability of drugs of abuse to increase brain dopamine concentration in limbic brain regions is considered crucial for their reinforcing effects (2,3). However, the Address reprint requests to Dr. Goldstein, Brookhaven National Laboratory, Medical Research, Bldg. 490, 30 Bell Ave, Upton, NY 11973; rgoldstein@bnl.gov (e-mail NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript increase in dopamine per se is insufficient to account for the process of addiction, since drugs of abuse increase dopamine in n...

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Section: Dysthymiamentioning

confidence: 99%

Drug Addiction and Its Underlying Neurobiological Basis: Neuroimaging Evidence for the Involvement of the Frontal Cortex

Goldstein

Volkow²

2002

AJP

2,325

102

1,717

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“…50 Psychomotor disturbance in those with MDD has also been associated with reduced cerebral blood flow in the putamen and caudate during a motor task. 51 A study using positron emission tomography found that dopaminergic function of the putamen is reduced in individuals with MDD compared with controls. 52 Given these findings, reduced putamen volumes may be associated with the psychomotor disturbance that characterizes many individuals with MDD, and these effects may be more pronounced later in life.…”

Section: J Psychiatry Neurosci 2017;42(3)mentioning

confidence: 99%

Accelerated aging of the putamen in patients with major depressive disorder

Sacchet

Camacho

Livermore

et al. 2017

JPN

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IntroductionMajor depressive disorder (MDD) is primarily characterized by depressed mood and a blunted experience of pleasure (i.e., anhedonia). 1 The disorder is prevalent and chronic and represents a substantial personal, social and economic burden. [2][3][4] Neuroscience promises to elucidate mechanisms under lying depressive pathophysiology, leading to more effective approaches to the prevention and treatment of this debilitating disorder.Considerable evidence indicates that reward processing is dysfunctional in individuals with MDD. 5,6 The basal ganglia (BG) are a set of subcortical structures, including the striatum (caudate and putamen), nucleus accumbens and pallidum, that are critically involved in these reward processing steps. 7Previously research has indicated that depressed individuals have decreased activation in the striatum, 5,6 and some investigators have hypothesized that this abnormal activity affects decision-making. 5 Research in both animals and humans suggests that the dorsal striatum is involved in action selection and initiation and in encoding and integrating sensorimotor, cognitive and motivational/emotional information.8 Current evidence is mixed regarding specific roles of the putamen and caudate in reward processing. The results of several studies using fMRI suggest that whereas the putamen specifi cally encodes reward-related feedback, the caudate encodes both reward and punishment feedback.9,10 Finally, researchers have reported that the putamen is activated most strongly during anticipation of reward, whereas the caudate is activated most strongly during the receipt of reward. 8,10,11 A growing body of research indicates that adults with MDD have smaller volumes of the caudate 12-15 and putamen 13,14,16,17 than healthy controls. Postmortem studies have also reported smaller putamen volumes in depressed than in nondepressed adults. 18 It is important to note that these studies typically include adult samples with a mean age older than 40 years. Depression-associated differences in BG volumes are less consistent in samples of both younger adults 19,20 and adolescents. 21 It appears, therefore, that this discrepancy is associated with age differences in the study Background: Growing evidence indicates that major depressive disorder (MDD) is characterized by accelerated biological aging, including greater age-related changes in physiological functioning. The disorder is also associated with abnormal neural reward circuitry, particularly in the basal ganglia (BG). Here we assessed age-related changes in BG volume in both patients with MDD and healthy control participants. Methods: We obtained whole-brain T 1 -weighted images from patients with MDD and healthy controls. We estimated grey matter volumes of the BG, including the nucleus accumbens, caudate, pallidum and putamen. Volumes were assessed using multivariate analysis of covariance (MANCOVA) with age as a covariate, followed by appropriate post hoc tests. Results: We included 232 individuals (116 patients with MDD) in our analy...

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“…Antiparkinsonian drugs such as l-DOPA and bromocriptine have mixed antidepressant charac teristics with regard to other symptoms of depression, but they do tend to improve anergia [141]. Imaging studies also have implicated the basal ganglia structures, as well as interconnected brain areas such as prefrontal cortex and anterior cingulate cortex, in p sychomotor slowing in depression [146,147].…”

Section: Clinical Significancementioning

confidence: 99%

Role of dopamine–adenosine interactions in the brain circuitry regulating effort-related decision making: insights into pathological aspects of motivation

Salamone

Correa²,

Farrar³

et al. 2010

Future Neurol.

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Review Dopaminergic involvement in activational aspects of motivationSimilar to other psychological constructs such as emotion and cognition, motivation is not a simple or unitary phenomenon. Motivation is a complex and multifacted process that includes many diverse components. Some aspects of motivation are related to sensations of internal and external stimuli, while other aspects of motivation are related to motor function [1]. Motivated behavior takes place in phases that represent different degrees of physical or psychological distance from the primary motivational stimulus (i.e., appetitive vs consummatory; instrumental vs consummatory; see [2][3][4]). Moreover, motivation theory and research has emphasized for several years that there are 'directional' and 'activational' aspects of motivation [5][6][7]. Directional aspects refer to the observation that the behavior of animals is directed towards or away from particular motivational stimuli. In addition, it is evident that motivated behavior can be characterized by persistence, vigor and high levels of work output; these activational aspects of motivated behavior are highly adaptive because they enable organisms to overcome challenges or work-related response costs that separate them from significant stimuli such as food [4,[8][9][10][11][12][13]. While foraging in the wild, animals can invest considerable time and can cover large areas of space in order to gain access to food or other primary motivational stimuli. Laboratory experiments have shown that animals can climb barriers, run in mazes or press levers on schedules with high input ratio requirements, in order to gain access to motivational stimuli such as food. Under some conditions the presentation of motivational stimuli can generate heightened, even excessive, levels of motor activity. In humans, impairments in behavioral activation can manifest themselves as energy-related symptoms such as psychomotor slowing, anergia and fatigue, which are features of depression, and can also be observed in other psychiatric or n eurological disorders [11].In addition to studying these behavioral processes involved in activational aspects of motivation, neuroscientists have also focused upon the brain mechanisms that are potentially involved. Several brain areas have been investigated, but one of the neural systems most closely associated with behavioral activation is the dopamine (DA) innervation of the nucleus accumbens [8][9][10][11]14,15]. Although the mesolimbic DA system has consistently been linked to aspects of drug reinforcement, and is often referred to as some type of 'pleasure' or 'reward' center, recent Brain dopamine, particularly in the nucleus accumbens, has been implicated in activational aspects of motivation and effort-related processes. Accumbens dopamine depletions reduce the tendency of rats to work for food, and alter effort-related decision making, but leave aspects of food motivation such as appetite intact. Recent evidence indicates that the purine neuromodulator adenosine, largely thr...

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Neo-striatal rCBF correlates of psychomotor slowing in patients with major depression

Cited by 58 publications

References 27 publications

Drug Addiction and Its Underlying Neurobiological Basis: Neuroimaging Evidence for the Involvement of the Frontal Cortex

Drug Addiction and Its Underlying Neurobiological Basis: Neuroimaging Evidence for the Involvement of the Frontal Cortex

Accelerated aging of the putamen in patients with major depressive disorder

Role of dopamine–adenosine interactions in the brain circuitry regulating effort-related decision making: insights into pathological aspects of motivation

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