neo-Clerodane diterpenoids from Ajuga: structural elucidation and biological activity

Coll, Josep Pujol i; Tandrón, Yudelsy A.

doi:10.1007/s11101-006-9023-3

Cited by 63 publications

(50 citation statements)

References 88 publications

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“…36 Ajugarin-1 ( 1298 ) showed moderate in vivo antiplasmodial activity, with an IC 50 of 23.0 ± 3.0 μM, against FCA 20/GHA P. falciparum . 504,505 At a dose of 200 mg kg −1 in mice, the clerodane diterpenoid gomphostenin-A ( 1299 ) exhibited an impressive 93% chemosuppression against P. berghei . 506 …”

Section: Biological Activitiesmentioning

confidence: 99%

Clerodane diterpenes: sources, structures, and biological activities

2016

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The clerodane diterpenoids are a widespread class of secondary metabolites and have been found in several hundreds of plant species from various families and in organisms from other taxonomic groups. These substances have attracted interest in recent years due to their notable biological activities, particularly insect antifeedant properties. In addition, the major active clerodanes of Salvia divinorum can be used as novel opioid receptor probes, allowing greater insight into opioid receptor-mediated phenomena, as well as opening additional areas for chemical investigation. This article provides extensive coverage of naturally occurring clerodane diterpenes discovered from 1990 until 2015, and follows up on the 1992 review by Merritt and Ley in this same journal. The distribution, chemotaxonomic significance, chemical structures, and biological activities of clerodane diterpenes are summarized. In the cases where sufficient information is available, structure activity relationship (SAR) correlations and mode of action of active clerodanes have been presented.

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Section: Biological Activitiesmentioning

confidence: 99%

Clerodane diterpenes: sources, structures, and biological activities

2016

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“…To the best of our knowledge, only Cole et al [3] have studied the activity of clerodin (3), jodrellin A (4) and jodrellin B (5) ( Figure 2) against the plant pathogenic fungi Fusarium oxysporum and Verticillium tricorpus. Antimicrobial activity of neo-clerodane diterpenoids lupulins A-C (6-8), isolated from Ajuga lupulina, against various Gram-positive and Gram-negative bacteria has also been published [8,9]. All mentioned compounds (3-8) contain either fragments 1a or 1b.…”

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confidence: 99%

Antimicrobial Activity of neo-Clerodane Diterpenoids isolated from Lamiaceae Species against Pathogenic and Food Spoilage Microorganisms

Bozov

Girova

Prisadova

et al. 2015

Natural Product Communications

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Antimicrobial activity of nineteen neo-clerodane diterpenoids, isolated from the acetone extracts of the aerial parts of Scutellaria and Salvia species (Lamiaceae) were tested against thirteen strains belonging to nine different species of pathogenic and food spoilage bacteria Aeromonas hydrophila, Bacillus cereus, Escherichia coli, Listeria monocytogenes, Proteus vulgaris, Pseudomonas aeruginosa, Pseudomonas fluorescens, Salmonella abony and Staphylococcus aureus as well as against two yeast strains belonging to species Candida albicans. Seven of the evaluated compounds scutalpin A, scutalpin E, scutalpin F, salviarin, splenolide A, splenolide B and splendidin demonstrated antimicrobial activity against used test microbial strains, the rest of the compounds were inactive within the studied concentration range. Among all of the tested compounds the highest antimicrobial activity was detected for scutalpin A against Staphylococcus aureus (MIC 25 µg/mL).

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“…It has been used as an astringent and for the treatment of swollen wounds, diarrhea, rheumatism, fever, eye trouble and for the diseases of bladder [21]. They also have the cancer chemo-preventive, hypoglycemic and hypotensive effects [22]. The present study was devised for the first time to understand the variation in growth characteristics and changes in allocation patterns in relation to the environmental conditions in two related species Ajuga bracteosa and A. parviflora growing at different altitudes of Kashmir Himalaya.…”

Section: Introductionmentioning

confidence: 99%

Green Options for Imparting Antibacterial Functionality to Cotton Fabrics

A¹,

A²,

M³

et al. 2017

Herb Med

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Ajuga is a medicinally important genus of the Himalayan region. This study was carried out on the phenotypic variability and reproductive allocation in two species of genus Ajuga, A. bracteosa and A. parviflora growing in variable habitats of Kashmir valley. Our findings clearly displayed significant divergence among sites which reveals a definite impact of altitude on morphological and reproductive features of the species under study. In A. bracteosa the plants growing at low altitudes are comparatively taller and produce more number of leaves, greater leaf dimensions and inflorescence number. But in case of A. parviflora a more or less reverse trend was seen. Principal component analysis (PCA) revealed that the habitat of Kangan and Dachigam proved relatively better for the growth of A. bracteosa and Brinal 2 and Gogaldara for A. parviflora. Maximum resources were allocated to the growth and development of the leaves followed by stem, root tubers and inflorescence in both the species. The reproductive effort was higher (40.48 ± 1.59) for the high altitude Betab valley population in case of A. bracteosa and was lowest for the high altitude Brinal 2 population (45.88 ± 1.37) in case of A. parviflora. The regression analysis revealed a positive correlation between branch length and root length, branch length and apical leaf length in both the species and a negative correlation between branch length and number of branches per plant in both the species. Our results are very useful to introduce the species into cultivation and developing strategies for conservation.

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neo-Clerodane diterpenoids from Ajuga: structural elucidation and biological activity

Cited by 63 publications

References 88 publications

Clerodane diterpenes: sources, structures, and biological activities

Clerodane diterpenes: sources, structures, and biological activities

Antimicrobial Activity of neo-Clerodane Diterpenoids isolated from Lamiaceae Species against Pathogenic and Food Spoilage Microorganisms

Green Options for Imparting Antibacterial Functionality to Cotton Fabrics

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