Biochemical Pharmacology volume 79, issue 7, P1062-1071 2010 DOI: 10.1016/j.bcp.2009.11.002 View full text
Jason Lei, Michael Leser, Essam Enan

Abstract: In vitro cultures of two nematodes (Caenorhabditis elegans and Ascaris suum) were established to study the nematicidal activity of three monoterpenoids (thymol, carvacrol and p-cymene). Toxicity of thymol and carvacrol was found for the two nematodes tested. The study was then aimed to address whether nematode tyramine receptor (TyrR) could interact with the two compounds by using HEK293 mammalian cells transfected with a C. elegans TyrR (ser-2) sequence, in hope of developing a high-throughput cell-based plat…

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