NEK2 plays an active role in Tumorigenesis and Tumor Microenvironment in Non-Small Cell Lung Cancer: Retraction

Bai, Rui; Yuan, Cheng; Sun, Wenjie; Zhang, Jianguo; Luo, Yuan; Gao, Yanping; Li, Yangyi; Gong, Yan; Xie, Conghua

doi:10.7150/ijbs.75303

Cited by 2 publications

(2 citation statements)

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“…In addition, NEK2 may also play a role in microtubule stabilization [70], B cell development and immunological response [71], and splicing [72]. NEK2 overexpression has been found in various human malignancies [73][74][75][76][77][78][79][80], including gastrointestinal tumors [81,82]. Aberrant NEK2 expression in cancers has been associated with tumor cell proliferation [83], migration [82], invasion [74,77], drug/radio resistance [84,85], immune response [80,86], and poor prognosis [26,75].…”

Section: Discussionmentioning

confidence: 99%

Differential Expression of NEK Kinase Family Members in Esophageal Adenocarcinoma and Barrett’s Esophagus

Chen,

Ballout,

et al. 2023

Cancers

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The incidence of esophageal adenocarcinoma (EAC) has risen rapidly during the past four decades, making it the most common type of esophageal cancer in the USA and Western countries. The NEK (Never in mitosis A (NIMA) related kinase) gene family is a group of serine/threonine kinases with 11 members. Aberrant expression of NEKs has been recently found in a variety of human cancers and plays important roles in tumorigenesis, progression, and drug-resistance. However, the expression of the NEKs in EAC and its precancerous condition (Barrett’s esophagus, BE) has not been investigated. In the present study, we first analyzed the TCGA and 9 GEO databases (a total of 10 databases in which 8 contain EAC and 6 contain BE) using bioinformatic approaches for NEKs expression in EAC and BE. We identified that several NEK members, such as NEK2 (7/8), NEK3 (6/8), and NEK6 (6/8), were significantly upregulated in EAC as compared to normal esophagus samples. Alternatively, NEK1 was downregulated in EAC as compared to the normal esophagus. On the contrary, genomic alterations of these NEKs are not frequent in EAC. We validated the above findings using qRT-PCR and the protein expression of NEKs in EAC cell lines using Western blotting and in primary EAC tissues using immunohistochemistry and immunofluorescence. Our data suggest that frequent upregulation of NEK2, NEK3, and NEK7 may be important in EAC.

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Section: Discussionmentioning

confidence: 99%

Differential Expression of NEK Kinase Family Members in Esophageal Adenocarcinoma and Barrett’s Esophagus

Chen,

Ballout,

et al. 2023

Cancers

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“…Lung cancer is a malignant tumor originating from the epithelium or glands of the bronchial mucosa (Bai et al, 2022). Chemotherapy, radiation therapy, targeted biological therapy, and immunotherapy are the current methods for treating lung cancer (Mazloum-Ravasan et al, 2022).…”

Section: Lung Cancermentioning

confidence: 99%

ZIP transporters‐regulated Zn²⁺ homeostasis: A novel determinant of human diseases

Liu,

Li,

2024

Journal Cellular Physiology

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As an essential trace element for organisms, zinc participates in various physiological processes, such as RNA transcription, DNA replication, cell proliferation, and cell differentiation. The destruction of zinc homeostasis is associated with various diseases. Zinc homeostasis is controlled by the cooperative action of zinc transporter proteins that are responsible for the influx and efflux of zinc. Zinc transporter proteins are mainly categorized into two families: Zrt/Irt‐like protein (SLC39A/ZIP) family and zinc transporter (SLC30A/ZNT) family. ZIP transporters contain 14 members, namely ZIP1‐14, which can be further divided into four subfamilies. Currently, ZIP transporters‐regulated zinc homeostasis is one of the research hotspots. Cumulative evidence suggests that ZIP transporters‐regulated zinc homeostasis may cause physiological dysfunction and contribute to the onset and progression of diverse diseases, such as cancers, neurological diseases, and cardiovascular diseases. In this review, we initially discuss the structure and distribution of ZIP transporters. Furthermore, we comprehensively review the latest research progress of ZIP transporters‐regulated zinc homeostasis in diseases, providing a new perspective into new therapeutic targets for treating related diseases.

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NEK2 plays an active role in Tumorigenesis and Tumor Microenvironment in Non-Small Cell Lung Cancer: Retraction

Cited by 2 publications

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Differential Expression of NEK Kinase Family Members in Esophageal Adenocarcinoma and Barrett’s Esophagus

Differential Expression of NEK Kinase Family Members in Esophageal Adenocarcinoma and Barrett’s Esophagus

ZIP transporters‐regulated Zn²⁺ homeostasis: A novel determinant of human diseases

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NEK2 plays an active role in Tumorigenesis and Tumor Microenvironment in Non-Small Cell Lung Cancer: Retraction

Cited by 2 publications

References 0 publications

Differential Expression of NEK Kinase Family Members in Esophageal Adenocarcinoma and Barrett’s Esophagus

Differential Expression of NEK Kinase Family Members in Esophageal Adenocarcinoma and Barrett’s Esophagus

ZIP transporters‐regulated Zn2+ homeostasis: A novel determinant of human diseases

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ZIP transporters‐regulated Zn²⁺ homeostasis: A novel determinant of human diseases