Negative symptoms in schizophrenia differ across environmental contexts in daily life

Luther, Lauren; Raugh, Ian M.; Collins, Delaney E; Knippenberg, Anna R.; Strauss, Gregory P.

doi:10.1016/j.jpsychires.2023.02.037

Cited by 7 publications

(12 citation statements)

References 49 publications

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“…electronically, in-person) had on temporally related negative symptoms of avolition, anhedonia, and asociality in CHR youth and CN. In line with our prior findings in SZ (Luther et al, 2023), we hypothesized that negative symptoms in CHR youth would change dynamically across different contexts. Given that CHR youth may be characterized by a true hedonic deficit more so than SZ (i.e.…”

Section: Introductionsupporting

confidence: 63%

“…For avolition, we found significant within-group differences in CHR youth, indicating that compared to being at rest, being at school/work, running errands, and commuting were associated with greater avolition, while engaging in recreation and watching TV were linked to lower avolition. Thus, much like SZ (Luther et al, 2023), activities more commonly associated with being ‘productive’ were associated with increases in avolition, while more pleasure-based activities were linked to reduced avolition. Given evidence of a hedonic deficit in CHR youth (e.g.…”

Section: Discussionmentioning

confidence: 91%

“…Following prior analytic methods (Luther et al, 2023), all models presented used mixed-effects modeling with random intercepts within person and day in order to account for nesting and repeated measures in the data. All effects evaluated used categorical variables; therefore, no random slopes were used.…”

Section: Discussionmentioning

confidence: 99%

“…Study procedures were completed across one week. Procedures were similar to past SZ studies (Luther et al, 2023;Raugh et al, 2021).…”

Section: Methodsmentioning

confidence: 98%

“…alone v. family, friends), and methods of social interactions (i.e. social modality; alone v. electronic communication) in schizophrenia (SZ) (Luther, Raugh, Collins, Knippenberg, & Strauss, 2023). Indirect environmental factors that reduce access to resources for recreational, goal-directed, and social activities (e.g.…”

Section: Introductionmentioning

confidence: 99%

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Environmental context predicts state fluctuations in negative symptoms in youth at clinical high risk for psychosis

et al. 2023

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Background Negative symptoms (avolition, anhedonia, asociality) are a prevalent symptom in those across the psychosis-spectrum and also occur at subclinical levels in the general population. Recent work has begun to examine how environmental contexts (e.g. locations) influence negative symptoms. However, limited work has evaluated how environments may contribute to negative symptoms among youth at clinical high risk for psychosis (CHR). The current study uses Ecological Momentary Assessment to assess how four environmental contexts (locations, activities, social interactions, social interaction method) impact state fluctuations in negative symptoms in CHR and healthy control (CN) participants. Methods CHR youth (n = 116) and CN (n = 61) completed 8 daily surveys for 6 days assessing negative symptoms and contexts. Results Mixed-effects modeling demonstrated that negative symptoms largely varied across contexts in both groups. CHR participants had higher negative symptoms than CN participants in most contexts, but groups had similar symptom reductions during recreational activities and phone call interactions. Among CHR participants, negative symptoms were elevated in several contexts, including studying/working, commuting, eating, running errands, and being at home. Conclusions Results demonstrate that negative symptoms dynamically change across some contexts in CHR participants. Negative symptoms were more intact in some contexts, while other contexts, notably some used to promote functional recovery, may exacerbate negative symptoms in CHR. Findings suggest that environmental factors should be considered when understanding state fluctuations in negative symptoms among those at CHR participants.

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Section: Introductionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

“…Study procedures were completed across one week. Procedures were similar to past SZ studies (Luther et al, 2023;Raugh et al, 2021).…”

Section: Methodsmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%