Negative regulation of autophagy by sulfide in Arabidopsis thaliana is independent of reactive oxygen species

Laureano-Marín, Ana M.; Moreno, Inmaculada; Romero, Luís C.; Gotor, Cecilia

doi:10.1104/pp.16.00110

Cited by 42 publications

(61 citation statements)

References 87 publications

(109 reference statements)

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“…This might lead to a mechanism in which NO could also directly inactivate the autophagic process. Moreover, NO was shown to induce the expression of genes encoding hydrogen sulfide (H 2 S)-synthesizing enzymes in tomato plants [131] resulting in higher levels of H 2 S, which inhibits autophagy by an unknown mechanism [132]. This effect of NO would be less relevant when SnRK1 is more active because SnRK1 was shown to phosphorylate nitrate reductase (NR), inactivating its activity and thus reducing NO production [133].…”

Section: Ros Levelsmentioning

confidence: 99%

Linking Autophagy to Abiotic and Biotic Stress Responses

Signorelli

Tarkowski

Ende

et al. 2019

Trends in Plant Science

227

176

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Autophagy is a process in which cellular components are delivered to lytic vacuoles to be recycled and has been demonstrated to promote abiotic/biotic stress tolerance. Here, we review how the responses triggered by stress conditions can affect autophagy and its signaling pathways. Besides the role of SNF-related kinase 1 (SnRK1) and TOR kinases in the regulation of autophagy, abscisic acid (ABA) and its signaling kinase SnRK2 have emerged as key players in the induction of autophagy under stress conditions. Furthermore, an interplay between reactive oxygen species (ROS) and autophagy is observed, ROS being able to induce autophagy and autophagy able to reduce ROS production. We also highlight the importance of osmotic adjustment for the successful performance of autophagy and discuss the potential role of GABA in plant survival and ethylene (ET)-induced autophagy.

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Section: Ros Levelsmentioning

confidence: 99%

Linking Autophagy to Abiotic and Biotic Stress Responses

Signorelli

Tarkowski

Ende

et al. 2019

Trends in Plant Science

227

176

View full text Add to dashboard Cite

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“…H 2 S has also been reported to play a very important role in autophagy (Laureano‐Marín et al ). In Arabidopsis, sulfide inhibits autophagy in the roots under nutrient deprivation by preventing the accumulation of ATG8 (AUTOPHAGY‐RELATED UBIQUITIN‐LIKE PROTEIN).…”

Section: Role Of No and H2s As Signaling Moleculesmentioning

confidence: 99%

Nitric oxide and hydrogen sulfide crosstalk during heavy metal stress in plants

Shivaraj

Vats

Bhat

et al. 2019

Physiologia Plantarum

105

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Gases such as ethylene, hydrogen peroxide (H 2 O 2 ), nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H 2 S) have been recognized as vital signaling molecules in plants and animals. Of these gasotransmitters, NO and H 2 S have recently gained momentum mainly because of their involvement in numerous cellular processes. It is therefore important to study their various attributes including their biosynthetic and signaling pathways. The present review provides an insight into various routes for the biosynthesis of NO and H 2 S as well as their signaling role in plant cells under different conditions, more particularly under heavy metal stress. Their beneficial roles in the plant's protection against abiotic and biotic stresses as well as their adverse effects have been addressed. This review describes how H 2 S and NO, being very small-sized molecules, can quickly pass through the cell membranes and trigger a multitude of responses to various factors, notably to various stress conditions such as drought, heat, osmotic, heavy metal and multiple biotic stresses. The versatile interactions between H 2 S and NO involved in the different molecular pathways have been discussed. In addition to the signaling role of H 2 S and NO, their direct role in posttranslational modifications is also considered. The information provided here will be helpful to better understand the multifaceted roles of H 2 S and NO in plants, particularly under stress conditions.

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“…Furthermore, addition of exogenous sulfide to a des1 mutant or genetic complementation of DES1 gene prevented the accumulation and lipidation of ATG8 proteins (Álvarez et al, 2012). Recently, it was demonstrated that the negative regulation of autophagy by sulfide is independent of reactive oxygen species, and sulfide therefore probably regulates autophagy by an alternative pathway (Laureano-Marín et al, 2016).…”

Section: Other Possible Regulatorsmentioning

confidence: 99%