Negative Emotions and Cytokines in Maternal and Cord Serum at Preterm Birth

Fransson, Emma; Dubicke, Aurelija; Byström, Birgitta; Ekman-Ordeberg, Gunvor; Hjelmstedt, Anna; Lekander, Mats

doi:10.1111/j.1600-0897.2011.01081.x

Cited by 33 publications

(29 citation statements)

References 47 publications

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“…Finally, Fransson et al (2012) measured the relationship between maternal emotions and cytokines at birth in both maternal serum and cord blood, and whether those parameters differed between women who delivered preterm and those who delivered at term. The sample included 27 women who delivered preterm and 37 who delivered at term.…”

Section: Resultsmentioning

confidence: 99%

“…The Kondo et al (2011) and Fransson et al (2012) studies, most recent of this group, did avoid some of the limitations of the earlier work in this subset. The Kondo et al study has a relatively large sample size, controls for possible confounders such as smoking, alcohol use, and history of allergic disease, and is highly representative (the sample includes all lactating mothers in the city).…”

Section: Discussionmentioning

confidence: 99%

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Perinatal depression—The fourth inflammatory morbidity of pregnancy?

Osborne

Monk

2013

Psychoneuroendocrinology

206

144

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Perinatal depression is one of the leading causes of maternal morbidity and mortality. The biological etiology of this disorder remains in question, despite considerable research into the contributions of hormonal imbalance, the role of monoamines, and dysregulation of the HPA axis. Because inflammation is known to be associated with major depression in men and non-perinatal women as well as with other important morbidities of pregnancy (such as preeclampsia, preterm birth, and gestational diabetes), and because these morbidities may correlate with perinatal depression, inflammation may be a common physiological pathway that can also help explain perinatal depression. In this paper, we review the theoretical background of inflammation in perinatal depression and then review the literature concerning immune and inflammatory factors in the etiology and course of perinatal depression. We close with recommendations for future studies in this still relatively unexplored area. Identification and understanding of a common pathophysiology between other pregnancy morbidities and perinatal depression would link physical and mental well-being, likely leading to better treatment and prevention.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Perinatal depression—The fourth inflammatory morbidity of pregnancy?

Osborne

Monk

2013

Psychoneuroendocrinology

206

144

View full text Add to dashboard Cite

show abstract

“…However, HGF have been reported elevated in older adults with subclinical symptoms of depression (Arnold et al, ). Moreover, elevated levels of IL‐18 have been reported in response to delivery in women with depressive symptoms during pregnancy (Fransson et al, ). Increased IL‐18 has also been associated with poststroke depression (Yang et al, ), while IL‐18 levels have been reported to be lower in depressed patients with chronic disease (Bossu et al, ; Fan, Luo, Ou, & He, ).…”

Section: Discussionmentioning

confidence: 99%

Inflammatory markers in women with postpartum depressive symptoms

Bränn

Fransson

White

et al. 2018

J of Neuroscience Research

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Postpartum depression (PPD) is a devastating disorder affecting not only more than 10% of all women giving birth, but also the baby, the family, and the society. Compiling evidence suggests the involvement of the immune system in the pathophysiology of major depression; yet, the immune response in perinatal depression is not as well studied. The aim of this study was to investigate the alterations in peripheral levels of inflammatory biomarkers in 169 Swedish women with and without depressive symptoms according to the Edinburgh postnatal depression scale or the M.I.N.I neuropsychiatric interview at eight weeks postpartum. Among the 70 markers analyzed with multiplex proximity extension assay, five were significantly elevated in women with postpartum depressive symptoms in the adjusted LASSO logistic regression analysis: Tumor necrosis factor ligand superfamily member (TRANCE) (OR-per 1 SD increase = 1.20), Hepatocyte growth factor (HGF) (OR = 1.17) Interleukin (IL)-18 (OR = 1.06), Fibroblast growth factor 23 (FGF-23) (OR = 1.25), and C-X-C motif chemokine 1 (CXCL1) (OR 1.11). These results indicate that women with PPD have elevated levels of some inflammatory biomarkers. It is, therefore, plausible that PPD is associated with a compromised adaptability of the immune system.

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“…Corwin et al (3 rd trimester and multiple postpartum timepoints, N=152) 69 found no association of IL-1β with depressive symptoms. Fransson et al (at delivery, N=64) 64 found no association of IL-1α in cord serum with maternal depressive symptoms. (This group attempted to measure both IL-1α and IL-1β in maternal serum at delivery as well but found both below the limit of detection of their assay.…”

Section: Depression and Inflammation In The Perinatal Periodmentioning

confidence: 94%

Roles of Inflammation and Depression in the Development of Gestational Diabetes

Robakis

Aasly

Williams

et al. 2017

Curr Behav Neurosci Rep

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Inflammation, the body’s response to harmful external agents, has long been found to be associated with depressive symptoms. The relationship between inflammation and depression is well established in the general population of people with depression, but is less so among perinatal women. Depression in the perinatal period is a common disorder, however available data do not indicate that there is a specific inflammatory picture associated with perinatal depression. We suggest that perinatal depression may be a heterogeneous construct, and that inflammation may be relevant to it in the context of other inflammatory morbidities of pregnancy. In this review we explore the available support for the hypothesis that inflammation associated with depression can represent a precipitating insult for the development of gestational diabetes, a known inflammatory morbidity of pregnancy.

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Negative Emotions and Cytokines in Maternal and Cord Serum at Preterm Birth

Abstract: The findings indicate associations in preterm delivery between negative emotions and both maternal and neonate immune activity. Future studies should investigate whether such associations are part of the etiology of preterm delivery.

Cited by 33 publications

References 47 publications

Perinatal depression—The fourth inflammatory morbidity of pregnancy?

Perinatal depression—The fourth inflammatory morbidity of pregnancy?

Inflammatory markers in women with postpartum depressive symptoms

Roles of Inflammation and Depression in the Development of Gestational Diabetes

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