Negative Correlation between Placental Growth Factor and Endocan-1 in Women with Preeclampsia

Abstract

Objective To analyze endocan-1, a biomarker of vascular endothelial related pathologies, and the placental growth factor (PlGF), an angiogenic factor and a placental dysfunction marker in patients with preeclampsia (PE). Methods Case-control study conducted at Hospital São Lucas, in the city of Porto Alegre, Brazil. Endocan-1 and PlGF levels were quantified in the maternal plasma using the MagPlexTH-C microsphere system (MAGPIX System, Luminex, Austin, Texas, US) and evaluated through analysis of covariance (ANCOVA) and adjusted by body mass index (BMI), gestational age and maternal age. To estimate the difference between the groups, the mean ratio (MR) and the 95% confidence interval (95%CI) were calculated. The Pearson correlation test was used to establish any association between endocan-1 and PlGF levels. The null hypothesis was rejected when p < 0.05. Results The group of patients was composed by normotensive (n = 67) patients and patients with PE (n = 50). A negative correlation between endocan-1 and the PlGF was noted in the entire normotensive group (linear correlation coefficient [r] = −0.605; p < 0.001), as well as in the PE group (r = −0.545; p < 0.001). Conclusion Endocan-1 levels are increased in patients with PE, and are inversely correlated with PlGF levels. We suggest that it is important to analyze angiogenic and proinflammatory molecules concomitantly in women with PE to better understand the pathophysiology of the disease. Both molecules are strong candidates for PE biomarkers, and future studies will examine any mechanisms connecting these factors in PE.

Are Endocan Plasma Levels Altered in Preeclampsia?

“…A review of the literature showed eight studies that investigated endocan in women with PE. 16 17 18 19 20 21 22 23 According to our data, two studies showed no significant difference between endocan levels in preeclamptic versus normotensive pregnancy. 16 18 However, five studies revealed increased levels in women with PE versus normotensive pregnancy 17 19 21 22 23 and two studies showed that endocan protein in the placenta tissue is upregulated in PE 18 20 suggesting its involvement in the pathogenesis of PE.…”

“…[16][17][18][19][20][21][22][23] According to our data, two studies showed no significant difference between endocan levels in preeclamptic versus normotensive pregnancy. 16,18 However, five studies revealed increased levels in women with PE versus normotensive pregnancy 17,19,[21][22][23] and two studies showed that endocan protein in the placenta tissue is upregulated in PE 18,20 suggesting its involvement in the pathogenesis of PE. Of note, among the studies that found a positive association between endocan levels and PE development, one was also conducted in Brazil.…”

“…Of note, among the studies that found a positive association between endocan levels and PE development, one was also conducted in Brazil. 22 It is well-established that high levels of tumor necrosis factor-α (TNF-α) and vascular endothelial growth factor (VEGF) are able to stimulate the expression of endocan. 24 25 It should be highlighted that the women with PE of the present study showed no previous increase of TNF-α plasma levels 3 and lower VEGF levels 26 comparing with normotensive pregnant.…”

Endocan: A Key Player of Cardiovascular Disease

“…Hentschke et al found that there is a negative correlation between endocan and placental growth factor in both the normotensive group and the preeclampsia group. Similarly, higher levels of endocan were found in the maternal plasma of the pre-eclampsia group, and the placental endocan levels of pre-eclampsia were lower ( 40 ). In addition, it was also found that the endocan concentration in maternal and fetal plasma was positively correlated, while the endocan level in maternal/fetal plasma was negatively correlated with fetal birth weight, placental weight, and gestational age ( 41 ).…”

Vanadium Pentaoksida (V2O5) : Termodinamika Molecular dan Interaksi Ion dalam Larutan

“…O,18 O, dengan16 O adalah unsur paling melimpah (99,762%). Isotop oksigen berkisar dari bernomor massa(69)(70)(71)(72) 12 sampai dengan 28 16. O disintesis pada prosess akhir fusi (73-77) helium terhadap bintang.…”