Neferine, a bisbenzylisoquinline alkaloid attenuates bleomycin-induced pulmonary fibrosis

Zhao, Libo; Wang, Xiaomin; Chang, Qing; Xu, Jinghui; Huang, Ying; Guo, Qiuyun; Zhang, Shaohui; Wang, Wenquan; Chen, Xiujuan; Wang, Jialing

doi:10.1016/j.ejphar.2009.11.007

Cited by 125 publications

(84 citation statements)

References 46 publications

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“…In previous research, it was demonstrated that Neferine had antiinflammation, antioxidation and anti-pulmonary fibrosis activities [4,14]. However, the mechanism is not clear.…”

Section: Discussionmentioning

confidence: 99%

“…Chen et al demonstrated that Neferine had an antifibrotic effect on CCl 4 -induced hepatic fibrosis in mice because of the reduced expression of transforming growth factor-β1 (TGF-β1) in the liver [13]. In addtion, it was reported that Neferine has anti-fibrotic and anti-inflammatory effects on the amiodarone and bleomycininduced lung fibrosis model [4,14]. Although, the previous data represented anti-fibrotic activities of Neferine in pulmonary fibrosis, the protective mechanism of Neferine in pulmonary fibrosis is not known.…”

Section: Introductionmentioning

confidence: 99%

“…Neferine, a major bisbenzylisoquinline alkaloid derived from seed embryo of the traditional Chinese medicine herbs Nelumbo nucifera Gaertn's [4]. Previous studies have demonstrated that Neferine has a number of biological and pharmacological activities, such as antiinflammation, antioxidation [5], anti-apoptosis [6], neuroprotective [7], nephroprotection [8] and anticancer effects [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

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Neferine Attenuates Epithelial-Mesenchymal Transition of Alveolar Epithelial Cells via TGF-β Signaling Pathway

Kong¹,

Li²,

Hu³

et al. 2017

Chemotherapy

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Background: Idiopathic pulmonary fibrosis (IPF) is an incurable, progressive, and fatal interstitial lung disease with the characteristics of lung tissue damage and an enhancement in extracellular matrix (ECM). Alveolar epithelial cells (AMs) are major target cells that can directly promote to occurring of pulmonary fibrosis by acquisition of a mesenchymal phenotype through epithelial-mesenchymal transition (EMT). Neferine, a component of Chinese herbs, has been thought to be involved in anti-fibrotic activity in experimental lung fibrosis. However, its mechanism is not clear. In this study, we explore the regulation of neferine in TGF-β-induced EMT in lung fibrosis model and illustrate its mechanism of action.

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“…In previous research, it was demonstrated that Neferine had antiinflammation, antioxidation and anti-pulmonary fibrosis activities [4,14]. However, the mechanism is not clear.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Neferine Attenuates Epithelial-Mesenchymal Transition of Alveolar Epithelial Cells via TGF-β Signaling Pathway

Kong¹,

Li²,

Hu³

et al. 2017

Chemotherapy

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“…Elsewhere in that paper [180], they have elevated NF-B activity as part of their cycle. e drug bleomycin has been shown to initiate some cases of PAH [162,181]. It is known to increase several mechanisms involved in the NO/ONOO − cycle including stimulating poly (ADP-ribose) polymerase (PARP), oxidative stress, superoxide generation, in�ammatory cytokines, oxidative stress, partial uncoupling of the NOSs (which is presumably caused by BH4 depletion), mitochondrial dysfunction, and NF-B elevation [181][182][183][184][185].…”

Section: Principlementioning

confidence: 99%

“…e drug bleomycin has been shown to initiate some cases of PAH [162,181]. It is known to increase several mechanisms involved in the NO/ONOO − cycle including stimulating poly (ADP-ribose) polymerase (PARP), oxidative stress, superoxide generation, in�ammatory cytokines, oxidative stress, partial uncoupling of the NOSs (which is presumably caused by BH4 depletion), mitochondrial dysfunction, and NF-B elevation [181][182][183][184][185]. Superoxide is speci�cally implicated in having a causal role in bleomycininitiated PAH because overexpression of superoxide dismutase in a mouse model lessens subsequent pulmonary hypertension, �brosis, and vascular remodeling following bleomycin treatment [185].…”

Section: Principlementioning

confidence: 99%

Pulmonary Hypertension Is a Probable NO/ONOO⁻Cycle Disease: A Review

Pall

2013

ISRN Hypertension

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e NO/ONOO − cycle is a primarily local biochemical/physiological vicious cycle that appears to cause a series of chronic in�ammatory diseases. is paper focuses on whether the cycle causes pulmonary arterial hypertension (PAH) when located in the pulmonary arteries. e cycle involves 12 elements, including superoxide, peroxynitrite (ONOO − ), nitric oxide (NO), oxidative stress, NF-B, in�ammatory cytokines, iNOS, mitochondrial dysfunction, intracellular calcium, tetrahydrobiopterin depletion, NMDA activity, and TRP receptor activity. 10 of the 12 are elevated in PAH (NMDA?, NO?) and 11 have documented causal roles in PAH. Each stressor that initiates cases of PAH acts to raise cycle elements, and may, therefore, initiate the cycle in this way. PAH involves a primarily local mechanism as required by the cycle and the symptoms and signs of PAH are generated by elements of the cycle. Endothelin-1, which acts as a causal factor in PAH, acts as part of the cycle; its synthesis is stimulated by cycle elements, and it, in turn, increases each element of the cycle. is extraordinary �t to the principles of the NO/ONOO − cycle allows one to conclude that PAH is a NO/ONOO − cycle disease, and this �t supports the cycle as a ma�or paradigm of chronic in�ammatory disease.

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Neferine, an alkaloid from lotus seed embryo, inhibits human lung cancer cell growth by MAPK activation and cell cycle arrest

2013

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Neferine is the major bisbenzylisoquinoline alkaloid isolated from the seed embryo of a traditional medicinal plant Nelumbo nucifera (Lotus). Epidemiological studies have revealed the therapeutic potential of lotus seed embryo. Although several mechanisms have been proposed, a clear anticancer action mechanism of neferine on lung cancer cells is still not known. Lung cancer is the most common cause of cancer death in the world, and the patients with advanced stage of nonsmall lung cancer require adjunct chemotherapy after surgical resection for the eradication of cancer cells. In this study, the effects of neferine were evaluated and characterized in A549 cells. Neferine induced apoptosis in a dose-dependent manner with the hypergeneration of reactive oxygen species, activation of MAPKs, lipid peroxidation, depletion of cellular antioxidant pool, loss of mitochondrial membrane potential, and intracellular calcium accumulation. Furthermore, neferine treatment leads to the inhibition of nuclear factor kappaB and Bcl2, upregulation of Bax and Bad, release of cytochrome C, activation of caspase cascade, and DNA fragmentation. In addition, neferine could induce p53 and its effector protein p21 and downregulation of cell cycle regulatory protein cyclin D1 thereby inducing G1 cell cycle arrest. These results suggest a novel function of neferine as an apoptosis inducer in lung cancer cells.

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Neferine, a bisbenzylisoquinline alkaloid attenuates bleomycin-induced pulmonary fibrosis

Cited by 125 publications

References 46 publications

Neferine Attenuates Epithelial-Mesenchymal Transition of Alveolar Epithelial Cells via TGF-β Signaling Pathway

Neferine Attenuates Epithelial-Mesenchymal Transition of Alveolar Epithelial Cells via TGF-β Signaling Pathway

Pulmonary Hypertension Is a Probable NO/ONOO⁻Cycle Disease: A Review

Neferine, an alkaloid from lotus seed embryo, inhibits human lung cancer cell growth by MAPK activation and cell cycle arrest

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Neferine, a bisbenzylisoquinline alkaloid attenuates bleomycin-induced pulmonary fibrosis

Cited by 125 publications

References 46 publications

Neferine Attenuates Epithelial-Mesenchymal Transition of Alveolar Epithelial Cells via TGF-β Signaling Pathway

Neferine Attenuates Epithelial-Mesenchymal Transition of Alveolar Epithelial Cells via TGF-β Signaling Pathway

Pulmonary Hypertension Is a Probable NO/ONOO−Cycle Disease: A Review

Neferine, an alkaloid from lotus seed embryo, inhibits human lung cancer cell growth by MAPK activation and cell cycle arrest

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Pulmonary Hypertension Is a Probable NO/ONOO⁻Cycle Disease: A Review