2010
DOI: 10.1007/s00402-010-1101-8
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Necrotizing fasciitis of the extremities: 34 cases at a single centre over the past 5 years

Abstract: Early recognition and treatment remain the most important factors influencing survival in NF. Yet, early diagnosis of the condition is difficult due to its similarities with other soft-tissue disorders. Repeated surgical debridement and incisional drainage continues to be essential for the survival. However, these infections continue to be a source of high morbidity, mortality and significant healthcare resource consumption. These challenging patients are best served with prompt diagnosis, immediate radical su… Show more

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Cited by 41 publications
(31 citation statements)
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“…16 The fascia typically will appear swollen and dull and has areas of necrosis. 22,33 Cultures and Gram stains should be obtained and antibiotic therapy started emergently with empiric coverage, including vancomycin and clindamycin. Clindamycin is an important adjunct to therapy because of its ability to suppress toxin production and modulate cytokine production in both S pyogenes and S aureus.…”
Section: Necrotizing Fasciitismentioning
confidence: 99%
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“…16 The fascia typically will appear swollen and dull and has areas of necrosis. 22,33 Cultures and Gram stains should be obtained and antibiotic therapy started emergently with empiric coverage, including vancomycin and clindamycin. Clindamycin is an important adjunct to therapy because of its ability to suppress toxin production and modulate cytokine production in both S pyogenes and S aureus.…”
Section: Necrotizing Fasciitismentioning
confidence: 99%
“…Clindamycin is an important adjunct to therapy because of its ability to suppress toxin production and modulate cytokine production in both S pyogenes and S aureus. 22,33 In cases where a Gram-negative bacterium or Clostridium species is possible, an extended spectrum betalactamase inhibitor antibiotic such as piperacillin, tazobactam, or a carbapenem should be added pending culture results. Outcomes do not depend on adequate antibiotic coverage, but most importantly by adequacy of debridement.…”
Section: Necrotizing Fasciitismentioning
confidence: 99%
“…Ce taux de mortalité, toutes localisations confondues, varie dans la littérature entre 4 et 74 % avec une moyenne à 25 à 30 % [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. Une revue de la littérature [27] [11] issue de la base de données du National Surgical Quality Improvment Program retrouve un taux de mortalité de seulement 12 %.…”
Section: Mortalitéunclassified
“…Physiopathologie [9,13,51] L'infection débute au niveau de l'hypoderme ou de l'aponévrose superficielle, les couches plus superficielles (derme et épiderme) étant épargnées au début. La combinaison des facteurs de virulence des germes et des facteurs propres à l'hôte intervient dans la constitution des DHBN-FN.…”
Section: Infections Fungiquesunclassified
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